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Association analysis of PPARGC1A mutations with meat quality parameters in a commercial hybrid pig population

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Abstract
Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) is a promising candidate gene for selection on meat and carcass quality traits in the pig industry. In the pig, several SNPs have been reported in both coding and regulatory regions of this gene, some of which were associated with fat characteristics, but none of these associations have been confirmed and many SNPs have not yet been evaluated. Therefore, 18 PPARGC1A SNPs were genotyped in 65 slaughter pigs of a commercial hybrid population and used in an association analysis with multiple muscle and carcass traits. Several SNPs located in the 3'UTR and exon 8 and 9 of PPARGC1A were significantly (P < 0.05-0.001) associated with various carcass composition, tenderness and muscle fibre traits. They could potentially serve as DNA selection markers, if their impact was to be confirmed by a functional analysis.
Keywords
carcass composition, association analysis, meat quality, pig, PPARGC1A, SNP, GROWTH-FACTOR-II, ADAPTIVE THERMOGENESIS, COACTIVATOR, MUSCLE, GAMMA, POLYMORPHISMS, CARCASS, TRAITS, GENE, FAT

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Chicago
Erkens, Tim, Stefaan De Smet, Karijn Van den Maagdenberg, Anneleen Stinckens, Nadine Buys, Alex Van Zeveren, and Luc Peelman. 2010. “Association Analysis of PPARGC1A Mutations with Meat Quality Parameters in a Commercial Hybrid Pig Population.” Czech Journal of Animal Science 55 (5): 200–208.
APA
Erkens, T., De Smet, S., Van den Maagdenberg, K., Stinckens, A., Buys, N., Van Zeveren, A., & Peelman, L. (2010). Association analysis of PPARGC1A mutations with meat quality parameters in a commercial hybrid pig population. CZECH JOURNAL OF ANIMAL SCIENCE, 55(5), 200–208.
Vancouver
1.
Erkens T, De Smet S, Van den Maagdenberg K, Stinckens A, Buys N, Van Zeveren A, et al. Association analysis of PPARGC1A mutations with meat quality parameters in a commercial hybrid pig population. CZECH JOURNAL OF ANIMAL SCIENCE. 2010;55(5):200–8.
MLA
Erkens, Tim, Stefaan De Smet, Karijn Van den Maagdenberg, et al. “Association Analysis of PPARGC1A Mutations with Meat Quality Parameters in a Commercial Hybrid Pig Population.” CZECH JOURNAL OF ANIMAL SCIENCE 55.5 (2010): 200–208. Print.
@article{947215,
  abstract     = {Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) is a promising candidate gene for selection on meat and carcass quality traits in the pig industry. In the pig, several SNPs have been reported in both coding and regulatory regions of this gene, some of which were associated with fat characteristics, but none of these associations have been confirmed and many SNPs have not yet been evaluated. Therefore, 18 PPARGC1A SNPs were genotyped in 65 slaughter pigs of a commercial hybrid population and used in an association analysis with multiple muscle and carcass traits. Several SNPs located in the 3'UTR and exon 8 and 9 of PPARGC1A were significantly (P {\textlangle} 0.05-0.001) associated with various carcass composition, tenderness and muscle fibre traits. They could potentially serve as DNA selection markers, if their impact was to be confirmed by a functional analysis.},
  author       = {Erkens, Tim and De Smet, Stefaan and Van den Maagdenberg, Karijn and Stinckens, Anneleen and Buys, Nadine and Van Zeveren, Alex and Peelman, Luc},
  issn         = {1212-1819},
  journal      = {CZECH JOURNAL OF ANIMAL SCIENCE},
  language     = {eng},
  number       = {5},
  pages        = {200--208},
  title        = {Association analysis of PPARGC1A mutations with meat quality parameters in a commercial hybrid pig population},
  volume       = {55},
  year         = {2010},
}

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