Rhinosinusitis and asthma : a link for asthma severity
- Author
- Claus Bachert (UGent) , Sofie Claeys (UGent) , Peter Tomassen (UGent) , Thibaut Van Zele (UGent) and Nan Zhang (UGent)
- Organization
- Abstract
- The term rhinosinusitis describes an inflammation of the mucosal lining of the nose and sinuses; however, recent evidence points to the need to differentiate patients with chronic rhinosinusitis without nasal polyps from those with nasal polyps. Asthma comorbidity is especially common in nasal polyp disease and may be associated with aspirin-exacerbated respiratory disease. Of interest, asthma comorbidity is uncommon in some parts of the world but common in others. A further analysis of the inflammatory patterns also revealed that nasal polyps do not represent one single entity; interleukin (IL)-5-positive nasal polyps can be differentiated from IL-5-negative forms by different inflammatory patterns (predominance of eosinophils vs neutrophils). Staphylococcus aureus superantigens frequently colonize IL-5-positive nasal polyps and may amplify the eosinophilic inflammation, induce a polyclonal local IgE formation, and increase the risk of asthma comorbidity. Recent findings in severe asthma patients confirm the role of superantigens in lower airway disease.
- Keywords
- Nasal polyps, Chronic rhinosinusitis, Asthma, Interleukin-5, IgE, ECP, Staphylococcus aureus enterotoxins, Superantigens, STAPHYLOCOCCUS-AUREUS ENTEROTOXINS, NASAL POLYPS, NONALLERGIC ASTHMA, CHRONIC SINUSITIS, IGE, INFLAMMATION, DISEASE, ALLERGY, CELLS, SUPERANTIGENS
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-946322
- MLA
- Bachert, Claus, et al. “Rhinosinusitis and Asthma : A Link for Asthma Severity.” CURRENT ALLERGY AND ASTHMA REPORTS, vol. 10, no. 3, 2010, pp. 194–201, doi:10.1007/s11882-010-0096-0.
- APA
- Bachert, C., Claeys, S., Tomassen, P., Van Zele, T., & Zhang, N. (2010). Rhinosinusitis and asthma : a link for asthma severity. CURRENT ALLERGY AND ASTHMA REPORTS, 10(3), 194–201. https://doi.org/10.1007/s11882-010-0096-0
- Chicago author-date
- Bachert, Claus, Sofie Claeys, Peter Tomassen, Thibaut Van Zele, and Nan Zhang. 2010. “Rhinosinusitis and Asthma : A Link for Asthma Severity.” CURRENT ALLERGY AND ASTHMA REPORTS 10 (3): 194–201. https://doi.org/10.1007/s11882-010-0096-0.
- Chicago author-date (all authors)
- Bachert, Claus, Sofie Claeys, Peter Tomassen, Thibaut Van Zele, and Nan Zhang. 2010. “Rhinosinusitis and Asthma : A Link for Asthma Severity.” CURRENT ALLERGY AND ASTHMA REPORTS 10 (3): 194–201. doi:10.1007/s11882-010-0096-0.
- Vancouver
- 1.Bachert C, Claeys S, Tomassen P, Van Zele T, Zhang N. Rhinosinusitis and asthma : a link for asthma severity. CURRENT ALLERGY AND ASTHMA REPORTS. 2010;10(3):194–201.
- IEEE
- [1]C. Bachert, S. Claeys, P. Tomassen, T. Van Zele, and N. Zhang, “Rhinosinusitis and asthma : a link for asthma severity,” CURRENT ALLERGY AND ASTHMA REPORTS, vol. 10, no. 3, pp. 194–201, 2010.
@article{946322,
abstract = {{The term rhinosinusitis describes an inflammation of the mucosal lining of the nose and sinuses; however, recent evidence points to the need to differentiate patients with chronic rhinosinusitis without nasal polyps from those with nasal polyps. Asthma comorbidity is especially common in nasal polyp disease and may be associated with aspirin-exacerbated respiratory disease. Of interest, asthma comorbidity is uncommon in some parts of the world but common in others. A further analysis of the inflammatory patterns also revealed that nasal polyps do not represent one single entity; interleukin (IL)-5-positive nasal polyps can be differentiated from IL-5-negative forms by different inflammatory patterns (predominance of eosinophils vs neutrophils). Staphylococcus aureus superantigens frequently colonize IL-5-positive nasal polyps and may amplify the eosinophilic inflammation, induce a polyclonal local IgE formation, and increase the risk of asthma comorbidity. Recent findings in severe asthma patients confirm the role of superantigens in lower airway disease.}},
author = {{Bachert, Claus and Claeys, Sofie and Tomassen, Peter and Van Zele, Thibaut and Zhang, Nan}},
issn = {{1529-7322}},
journal = {{CURRENT ALLERGY AND ASTHMA REPORTS}},
keywords = {{Nasal polyps,Chronic rhinosinusitis,Asthma,Interleukin-5,IgE,ECP,Staphylococcus aureus enterotoxins,Superantigens,STAPHYLOCOCCUS-AUREUS ENTEROTOXINS,NASAL POLYPS,NONALLERGIC ASTHMA,CHRONIC SINUSITIS,IGE,INFLAMMATION,DISEASE,ALLERGY,CELLS,SUPERANTIGENS}},
language = {{eng}},
number = {{3}},
pages = {{194--201}},
title = {{Rhinosinusitis and asthma : a link for asthma severity}},
url = {{http://doi.org/10.1007/s11882-010-0096-0}},
volume = {{10}},
year = {{2010}},
}
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