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Tumor necrosis factor-mediated cell death: to break or to burst, that's the question

Franky Van Herreweghe (UGent) , Nele Festjens (UGent) , Wim Declercq (UGent) and Peter Vandenabeele (UGent)
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Abstract
In this review, we discuss the signal-transduction pathways of three major cellular responses induced by tumor necrosis factor (TNF): cell survival through NF-kB activation, apoptosis, and necrosis. Recruitment and activation of caspases plays a crucial role in the initiation and execution of TNF-induced apoptosis. However, experimental inhibition of caspases reveals an alternative cell death pathway, namely necrosis, also called necroptosis, suggesting that caspases actively suppress the latter outcome. TNF-induced necrotic cell death crucially depends on the kinase activity of receptor interacting protein serinethreonine kinase 1 (RIP1) and RIP3. It was recently demonstrated that ubiquitination of RIP1 determines whether it will function as a pro-survival or pro-cell death molecule. Deeper insight into the mechanisms that control the molecular switches between cell survival and cell death will help us to understand why TNF can exert so many different biological functions in the etiology and pathogenesis of human diseases.
Keywords
P55 TNF-RECEPTOR, INDUCED PROXIMITY MODEL, INTERACTING PROTEIN, INDUCED APOPTOSIS, Receptor interacting protein kinase 1, Apoptosis, Necrosis, CYTOSOLIC PHOSPHOLIPASE A(2), Tumor necrosis factor, CYTOCHROME-C RELEASE, NF-KAPPA-B, PERMEABILITY TRANSITION PORE, MEMBRANE PERMEABILIZATION, UBIQUITIN LIGASE

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Chicago
Van Herreweghe, Franky, Nele Festjens, Wim Declercq, and Peter Vandenabeele. 2010. “Tumor Necrosis Factor-mediated Cell Death: To Break or to Burst, That’s the Question.” Cellular and Molecular Life Sciences 67 (10): 1567–1579.
APA
Van Herreweghe, F., Festjens, N., Declercq, W., & Vandenabeele, P. (2010). Tumor necrosis factor-mediated cell death: to break or to burst, that’s the question. CELLULAR AND MOLECULAR LIFE SCIENCES, 67(10), 1567–1579.
Vancouver
1.
Van Herreweghe F, Festjens N, Declercq W, Vandenabeele P. Tumor necrosis factor-mediated cell death: to break or to burst, that’s the question. CELLULAR AND MOLECULAR LIFE SCIENCES. 2010;67(10):1567–79.
MLA
Van Herreweghe, Franky et al. “Tumor Necrosis Factor-mediated Cell Death: To Break or to Burst, That’s the Question.” CELLULAR AND MOLECULAR LIFE SCIENCES 67.10 (2010): 1567–1579. Print.
@article{943997,
  abstract     = {In this review, we discuss the signal-transduction pathways of three major cellular responses induced by tumor necrosis factor (TNF): cell survival through NF-kB activation, apoptosis, and necrosis. Recruitment and activation of caspases plays a crucial role in the initiation and execution of TNF-induced apoptosis. However, experimental inhibition of caspases reveals an alternative cell death pathway, namely necrosis, also called necroptosis, suggesting that caspases actively suppress the latter outcome. TNF-induced necrotic cell death crucially depends on the kinase activity of receptor interacting protein serinethreonine kinase 1 (RIP1) and RIP3. It was recently demonstrated that ubiquitination of RIP1 determines whether it will function as a pro-survival or pro-cell death molecule. Deeper insight into the mechanisms that control the molecular switches between cell survival and cell death will help us to understand why TNF can exert so many different biological functions in the etiology and pathogenesis of human diseases.},
  author       = {Van Herreweghe, Franky and Festjens, Nele and Declercq, Wim and Vandenabeele, Peter},
  issn         = {1420-682X},
  journal      = {CELLULAR AND MOLECULAR LIFE SCIENCES},
  keywords     = {P55 TNF-RECEPTOR,INDUCED PROXIMITY MODEL,INTERACTING PROTEIN,INDUCED APOPTOSIS,Receptor interacting protein kinase 1,Apoptosis,Necrosis,CYTOSOLIC PHOSPHOLIPASE A(2),Tumor necrosis factor,CYTOCHROME-C RELEASE,NF-KAPPA-B,PERMEABILITY TRANSITION PORE,MEMBRANE PERMEABILIZATION,UBIQUITIN LIGASE},
  language     = {eng},
  number       = {10},
  pages        = {1567--1579},
  title        = {Tumor necrosis factor-mediated cell death: to break or to burst, that's the question},
  url          = {http://dx.doi.org/10.1007/s00018-010-0283-0},
  volume       = {67},
  year         = {2010},
}

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