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The food contaminant fumonisin B1 reduces the maturation of porcine CD11R1+ intestinal antigen presenting cells and antigen-specific immune responses, leading to a prolonged intestinal ETEC infection

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Abstract
Consumption of food or feed contaminated with fumonisin B1 (FB1), a mycotoxin produced by Fusarium verticillioides, can lead to disease in humans and animals. The present study was conducted to examine the effect of FB1 intake on the intestinal immune system. Piglets were used as a target and as a model species for humans since their gastro-intestinal tract is very similar. The animals were orally exposed to a low dose of FB1 (1 mg/kg body weight FB1) for 10 days which did not result in any clinical signs. However, when compared to non-exposed animals, FB1-exposed animals showed a longer shedding of F4+ enterotoxigenic Escherichia coli (ETEC) following infection and a reduced induction of the antigen-specific immune response following oral immunization. Further analyses to elucidate the mechanisms behind these observations revealed a reduced intestinal expression of IL-12p40 and an impaired function of intestinal dendritic cells, with decreased upregulation of MHC-II and a reduced T cell stimulatory capacity upon stimulation. Taken together, these results indicate an FB1-mediated reduction of in vivo DC maturation.

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MLA
Devriendt, Bert, Mélanie Gallois, Frank Verdonck, et al. “The Food Contaminant Fumonisin B1 Reduces the Maturation of Porcine CD11R1+ Intestinal Antigen Presenting Cells and Antigen-specific Immune Responses, Leading to a Prolonged Intestinal ETEC Infection.” Modern Mucosal Vaccines, Adjuvants and Microbicides, 2nd International Conference, Abstracts. 2010. Print.
APA
Devriendt, B., Gallois, M., Verdonck, F., Wache, Y., Bimczok, D., Oswald, I., Goddeeris, B., et al. (2010). The food contaminant fumonisin B1 reduces the maturation of porcine CD11R1+ intestinal antigen presenting cells and antigen-specific immune responses, leading to a prolonged intestinal ETEC infection. Modern Mucosal Vaccines, Adjuvants and Microbicides, 2nd International conference, Abstracts. Presented at the 2nd International conference on Modern Mucosal Vaccines, Adjuvants and Microbicides (MMVAM 2010).
Chicago author-date
Devriendt, Bert, Mélanie Gallois, Frank Verdonck, Yann Wache, Diane Bimczok, Isabelle Oswald, Bruno Goddeeris, and Eric Cox. 2010. “The Food Contaminant Fumonisin B1 Reduces the Maturation of Porcine CD11R1+ Intestinal Antigen Presenting Cells and Antigen-specific Immune Responses, Leading to a Prolonged Intestinal ETEC Infection.” In Modern Mucosal Vaccines, Adjuvants and Microbicides, 2nd International Conference, Abstracts.
Chicago author-date (all authors)
Devriendt, Bert, Mélanie Gallois, Frank Verdonck, Yann Wache, Diane Bimczok, Isabelle Oswald, Bruno Goddeeris, and Eric Cox. 2010. “The Food Contaminant Fumonisin B1 Reduces the Maturation of Porcine CD11R1+ Intestinal Antigen Presenting Cells and Antigen-specific Immune Responses, Leading to a Prolonged Intestinal ETEC Infection.” In Modern Mucosal Vaccines, Adjuvants and Microbicides, 2nd International Conference, Abstracts.
Vancouver
1.
Devriendt B, Gallois M, Verdonck F, Wache Y, Bimczok D, Oswald I, et al. The food contaminant fumonisin B1 reduces the maturation of porcine CD11R1+ intestinal antigen presenting cells and antigen-specific immune responses, leading to a prolonged intestinal ETEC infection. Modern Mucosal Vaccines, Adjuvants and Microbicides, 2nd International conference, Abstracts. 2010.
IEEE
[1]
B. Devriendt et al., “The food contaminant fumonisin B1 reduces the maturation of porcine CD11R1+ intestinal antigen presenting cells and antigen-specific immune responses, leading to a prolonged intestinal ETEC infection,” in Modern Mucosal Vaccines, Adjuvants and Microbicides, 2nd International conference, Abstracts, Dublin, Ireland, 2010.
@inproceedings{941152,
  abstract     = {Consumption of food or feed contaminated with fumonisin B1 (FB1), a mycotoxin produced by Fusarium verticillioides, can lead to disease in humans and animals. The present study was conducted to examine the effect of FB1 intake on the intestinal immune system. Piglets were used as a target and as a model species for humans since their gastro-intestinal tract is very similar. The animals were orally exposed to a low dose of FB1 (1 mg/kg body weight FB1) for 10 days which did not result in any clinical signs. However, when compared to non-exposed animals, FB1-exposed animals showed a longer shedding of F4+ enterotoxigenic Escherichia coli (ETEC) following infection and a reduced induction of the antigen-specific immune response following oral immunization. Further analyses to elucidate the mechanisms behind these observations revealed a reduced intestinal expression of IL-12p40 and an impaired function of intestinal dendritic cells, with decreased upregulation of MHC-II and a reduced T cell stimulatory capacity upon stimulation. Taken together, these results indicate an FB1-mediated reduction of in vivo DC maturation.},
  author       = {Devriendt, Bert and Gallois, Mélanie and Verdonck, Frank and Wache, Yann and Bimczok, Diane and Oswald, Isabelle and Goddeeris, Bruno and Cox, Eric},
  booktitle    = {Modern Mucosal Vaccines, Adjuvants and Microbicides, 2nd International conference, Abstracts},
  language     = {eng},
  location     = {Dublin, Ireland},
  title        = {The food contaminant fumonisin B1 reduces the maturation of porcine CD11R1+ intestinal antigen presenting cells and antigen-specific immune responses, leading to a prolonged intestinal ETEC infection},
  year         = {2010},
}