Advanced search
1 file | 415.84 KB Add to list

Mammary involution in dairy animals

Anthony Capuco (UGent) and RM Akers
Author
Organization
Abstract
Lifetime milk production is maximized when dairy cows are pregnant during approximately 70% of each lactation. Between lactations, a nonlactating period is necessary for optimal milk production in the succeeding lactation. With cessation of milking, alveolar structure is largely maintained and little or no loss of cells occurs. However, increased apoptosis and cell proliferation, relative to that in lactating glands during the same stage of gestation, suggest that a nonlactating period serves to promote cell turnover prior to the next lactation. Even in the absence of pregnancy, mammary involution in dairy animals occurs at a slower rate than in rodents; alveolar structure is maintained for several weeks and lactation can be reinitiated after four weeks or more of involution. Although apoptosis appears to be initiated within a similar time frame to that in rodents, the maximum proportion of apoptotic epithelial cells appears to be lower than in rodents, and apoptosis may be accompanied by an initial increase in cell proliferation. The ability to manipulate apoptosis and cell proliferation during the nonlactating period and during lactation is expected to provide enormous benefits to the dairy industry.
Keywords
cow, mammary involution, goat, sheep, cell turnover, apoptosis, PROGRAMMED CELL-DEATH, DRY PERIOD LENGTH, MILK-PRODUCTION, GLAND INVOLUTION, APOPTOSIS, TISSUE, LACTATION, GROWTH, PATHWAYS, GOATS

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 415.84 KB

Citation

Please use this url to cite or link to this publication:

MLA
Capuco, Anthony, and RM Akers. “Mammary Involution in Dairy Animals.” JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA 4.2 (1999): 137–144. Print.
APA
Capuco, A., & Akers, R. (1999). Mammary involution in dairy animals. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 4(2), 137–144.
Chicago author-date
Capuco, Anthony, and RM Akers. 1999. “Mammary Involution in Dairy Animals.” Journal of Mammary Gland Biology and Neoplasia 4 (2): 137–144.
Chicago author-date (all authors)
Capuco, Anthony, and RM Akers. 1999. “Mammary Involution in Dairy Animals.” Journal of Mammary Gland Biology and Neoplasia 4 (2): 137–144.
Vancouver
1.
Capuco A, Akers R. Mammary involution in dairy animals. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA. 1999;4(2):137–44.
IEEE
[1]
A. Capuco and R. Akers, “Mammary involution in dairy animals,” JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, vol. 4, no. 2, pp. 137–144, 1999.
@article{932286,
  abstract     = {Lifetime milk production is maximized when dairy cows are pregnant during approximately 70% of each lactation. Between lactations, a nonlactating period is necessary for optimal milk production in the succeeding lactation. With cessation of milking, alveolar structure is largely maintained and little or no loss of cells occurs. However, increased apoptosis and cell proliferation, relative to that in lactating glands during the same stage of gestation, suggest that a nonlactating period serves to promote cell turnover prior to the next lactation. Even in the absence of pregnancy, mammary involution in dairy animals occurs at a slower rate than in rodents; alveolar structure is maintained for several weeks and lactation can be reinitiated after four weeks or more of involution. Although apoptosis appears to be initiated within a similar time frame to that in rodents, the maximum proportion of apoptotic epithelial cells appears to be lower than in rodents, and apoptosis may be accompanied by an initial increase in cell proliferation. The ability to manipulate apoptosis and cell proliferation during the nonlactating period and during lactation is expected to provide enormous benefits to the dairy industry.},
  author       = {Capuco, Anthony and Akers, RM},
  issn         = {1083-3021},
  journal      = {JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA},
  keywords     = {cow,mammary involution,goat,sheep,cell turnover,apoptosis,PROGRAMMED CELL-DEATH,DRY PERIOD LENGTH,MILK-PRODUCTION,GLAND INVOLUTION,APOPTOSIS,TISSUE,LACTATION,GROWTH,PATHWAYS,GOATS},
  language     = {eng},
  number       = {2},
  pages        = {137--144},
  title        = {Mammary involution in dairy animals},
  url          = {http://www.springerlink.com/content/p722352524j9n364/fulltext.pdf},
  volume       = {4},
  year         = {1999},
}

Web of Science
Times cited: