An emerging role for p21-activated kinases (Paks) in viral infections
- Author
- Celine Van den Broeke (UGent) , Maria Radu, Jonathan Chernoff and Herman Favoreel (UGent)
- Organization
- Abstract
- p21-activated protein kinases (Paks) are cytosolic serine/threonine protein kinases that act as effectors for small (p21) GTPases of the Cdc42 and Rac families. It has long been established that Paks play a major role in a host of vital cellular functions such as proliferation, survival and motility, and abnormal Pak function is associated with a number of human diseases. Here, we discuss emerging evidence that these enzymes also play a major role in the entry, replication and spread of many important pathogenic human viruses, including HIV. Careful assessment of the potential role of Paks in antiviral immunity will be pivotal to evaluate thoroughly the potential of agents that inhibit Pak as a new class of anti-viral therapeutics.
- Keywords
- SIMIAN-IMMUNODEFICIENCY-VIRUS, RHESUS MACAQUES, VIRUS TYPE-1 NEF, HEPATITIS-B-VIRUS, STRESS FIBER BREAKDOWN, CELLULAR SERINE KINASE, PROTEIN-KINASE, ACTIN CYTOSKELETON, PSEUDORABIES VIRUS, HIV-1 NEF
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-924514
- MLA
- Van den Broeke, Celine et al. “An Emerging Role for P21-activated Kinases (Paks) in Viral Infections.” TRENDS IN CELL BIOLOGY 20.3 (2010): 160–169. Print.
- APA
- Van den Broeke, C., Radu, M., Chernoff, J., & Favoreel, H. (2010). An emerging role for p21-activated kinases (Paks) in viral infections. TRENDS IN CELL BIOLOGY, 20(3), 160–169.
- Chicago author-date
- Van den Broeke, Celine, Maria Radu, Jonathan Chernoff, and Herman Favoreel. 2010. “An Emerging Role for P21-activated Kinases (Paks) in Viral Infections.” Trends in Cell Biology 20 (3): 160–169.
- Chicago author-date (all authors)
- Van den Broeke, Celine, Maria Radu, Jonathan Chernoff, and Herman Favoreel. 2010. “An Emerging Role for P21-activated Kinases (Paks) in Viral Infections.” Trends in Cell Biology 20 (3): 160–169.
- Vancouver
- 1.Van den Broeke C, Radu M, Chernoff J, Favoreel H. An emerging role for p21-activated kinases (Paks) in viral infections. TRENDS IN CELL BIOLOGY. 2010;20(3):160–9.
- IEEE
- [1]C. Van den Broeke, M. Radu, J. Chernoff, and H. Favoreel, “An emerging role for p21-activated kinases (Paks) in viral infections,” TRENDS IN CELL BIOLOGY, vol. 20, no. 3, pp. 160–169, 2010.
@article{924514,
abstract = {p21-activated protein kinases (Paks) are cytosolic serine/threonine protein kinases that act as effectors for small (p21) GTPases of the Cdc42 and Rac families. It has long been established that Paks play a major role in a host of vital cellular functions such as proliferation, survival and motility, and abnormal Pak function is associated with a number of human diseases. Here, we discuss emerging evidence that these enzymes also play a major role in the entry, replication and spread of many important pathogenic human viruses, including HIV. Careful assessment of the potential role of Paks in antiviral immunity will be pivotal to evaluate thoroughly the potential of agents that inhibit Pak as a new class of anti-viral therapeutics.},
author = {Van den Broeke, Celine and Radu, Maria and Chernoff, Jonathan and Favoreel, Herman},
issn = {0962-8924},
journal = {TRENDS IN CELL BIOLOGY},
keywords = {SIMIAN-IMMUNODEFICIENCY-VIRUS,RHESUS MACAQUES,VIRUS TYPE-1 NEF,HEPATITIS-B-VIRUS,STRESS FIBER BREAKDOWN,CELLULAR SERINE KINASE,PROTEIN-KINASE,ACTIN CYTOSKELETON,PSEUDORABIES VIRUS,HIV-1 NEF},
language = {eng},
number = {3},
pages = {160--169},
title = {An emerging role for p21-activated kinases (Paks) in viral infections},
url = {http://dx.doi.org/10.1016/j.tcb.2009.12.005},
volume = {20},
year = {2010},
}
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