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Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002-2004: the ARBAO-II study

Rene S Hendriksen, Dik J Mevius, Andreas Schroeter, Christopher Teale, Eric Jouy, Patrick Butaye UGent, Alessia Franco, Andra Utinane, Alice Amado and Miguel Moreno, et al. (2008) ACTA VETERINARIA SCANDINAVICA. 50.
abstract
Background: The project "Antibiotic resistance in bacteria of animal origin - II" (ARBAO-II) was funded by the European Union (FAIR5-QLK2-2002-01146) for the period 2003-05. The aim of this project was to establish a program for the continuous monitoring of antimicrobial susceptibility of pathogenic and indicator bacteria from food animals using validated and harmonised methodologies. In this report the first data on the occurrence of antimicrobial resistance among bacteria causing infections in pigs are reported. Methods: Susceptibility data from 17,642 isolates of pathogens and indicator bacteria including Actinobacillus pleuropneumoniae, Streptococcus suis and Escherichia coli isolated from pigs were collected from fifteen European countries in 2002-2004. Results: Data for A. pleuropneumoniae from infected pigs were submitted from five countries. Most of the isolates from Denmark were susceptible to all drugs tested with the exceptions of a low frequency of resistance to tetracycline and trimethoprim - sulphonamide. Data for S. suis were obtained from six countries. In general, a high level of resistance to tetracycline (48.0 - 92.0%) and erythromycin (29.1 - 75.0%) was observed in all countries whereas the level of resistance to ciprofloxacin and penicillin differed between the reporting countries. Isolates from England (and Wales), France and The Netherlands were all susceptible to penicillin. In contrast the proportion of strains resistant to ciprofloxacin ranged from 12.6 to 79.0% (2004) and to penicillin from 8.1 - 13.0% (2004) in Poland and Portugal. Data for E. coli from infected and healthy pigs were obtained from eleven countries. The data reveal a high level of resistance to tetracyclines, streptomycin and ampicillin among infected pigs whereas in healthy pigs the frequency of resistance was lower. Conclusion: Bacterial resistance to some antimicrobials was frequent with different levels of resistance being observed to several antimicrobial agents in different countries. The occurrence of resistance varied distinctly between isolates from healthy and diseased pigs, with the isolates from healthy pigs generally showing a lower level of resistance than those from diseased pigs. The study suggests that the choice of antimicrobials used for the treatment of diseased animals should preferably be based on knowledge of the local pattern of resistance.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SUSCEPTIBILITY, STRAINS, SEROLOGICAL CHARACTERIZATION, KOREA, ESCHERICHIA-COLI, DENMARK
journal title
ACTA VETERINARIA SCANDINAVICA
Acta Vet. Scand.
volume
50
article_number
19
pages
10 pages
Web of Science type
Article
Web of Science id
000257870200001
JCR category
VETERINARY SCIENCES
JCR impact factor
0.899 (2008)
JCR rank
57/133 (2008)
JCR quartile
2 (2008)
ISSN
0044-605X
DOI
10.1186/1751-0147-50-19
language
English
UGent publication?
no
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
923484
handle
http://hdl.handle.net/1854/LU-923484
date created
2010-04-12 14:52:57
date last changed
2010-09-21 11:02:56
@article{923484,
  abstract     = {Background: The project {\textacutedbl}Antibiotic resistance in bacteria of animal origin - II{\textacutedbl} (ARBAO-II) was funded by the European Union (FAIR5-QLK2-2002-01146) for the period 2003-05. The aim of this project was to establish a program for the continuous monitoring of antimicrobial susceptibility of pathogenic and indicator bacteria from food animals using validated and harmonised methodologies. In this report the first data on the occurrence of antimicrobial resistance among bacteria causing infections in pigs are reported.
Methods: Susceptibility data from 17,642 isolates of pathogens and indicator bacteria including Actinobacillus pleuropneumoniae, Streptococcus suis and Escherichia coli isolated from pigs were collected from fifteen European countries in 2002-2004.
Results: Data for A. pleuropneumoniae from infected pigs were submitted from five countries. Most of the isolates from Denmark were susceptible to all drugs tested with the exceptions of a low frequency of resistance to tetracycline and trimethoprim - sulphonamide.
Data for S. suis were obtained from six countries. In general, a high level of resistance to tetracycline (48.0 - 92.0\%) and erythromycin (29.1 - 75.0\%) was observed in all countries whereas the level of resistance to ciprofloxacin and penicillin differed between the reporting countries. Isolates from England (and Wales), France and The Netherlands were all susceptible to penicillin. In contrast the proportion of strains resistant to ciprofloxacin ranged from 12.6 to 79.0\% (2004) and to penicillin from 8.1 - 13.0\% (2004) in Poland and Portugal.
Data for E. coli from infected and healthy pigs were obtained from eleven countries. The data reveal a high level of resistance to tetracyclines, streptomycin and ampicillin among infected pigs whereas in healthy pigs the frequency of resistance was lower.
Conclusion: Bacterial resistance to some antimicrobials was frequent with different levels of resistance being observed to several antimicrobial agents in different countries. The occurrence of resistance varied distinctly between isolates from healthy and diseased pigs, with the isolates from healthy pigs generally showing a lower level of resistance than those from diseased pigs.
The study suggests that the choice of antimicrobials used for the treatment of diseased animals should preferably be based on knowledge of the local pattern of resistance.},
  articleno    = {19},
  author       = {Hendriksen, Rene S and Mevius, Dik J and Schroeter, Andreas and Teale, Christopher and Jouy, Eric and Butaye, Patrick and Franco, Alessia and Utinane, Andra and Amado, Alice and Moreno, Miguel and Greko, Christina and Stark, Katharina and Berghold, Christian and Myllyniemi, Anna-Liisa and Hoszowski, Andrzej and Sunde, Marianne and Aarestrup, Frank M},
  issn         = {0044-605X},
  journal      = {ACTA VETERINARIA SCANDINAVICA},
  keyword      = {SUSCEPTIBILITY,STRAINS,SEROLOGICAL CHARACTERIZATION,KOREA,ESCHERICHIA-COLI,DENMARK},
  language     = {eng},
  pages        = {10},
  title        = {Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002-2004: the ARBAO-II study},
  url          = {http://dx.doi.org/10.1186/1751-0147-50-19},
  volume       = {50},
  year         = {2008},
}

Chicago
Hendriksen, Rene S, Dik J Mevius, Andreas Schroeter, Christopher Teale, Eric Jouy, Patrick Butaye, Alessia Franco, et al. 2008. “Occurrence of Antimicrobial Resistance Among Bacterial Pathogens and Indicator Bacteria in Pigs in Different European Countries from Year 2002-2004: The ARBAO-II Study.” Acta Veterinaria Scandinavica 50.
APA
Hendriksen, R. S., Mevius, D. J., Schroeter, A., Teale, C., Jouy, E., Butaye, P., Franco, A., et al. (2008). Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002-2004: the ARBAO-II study. ACTA VETERINARIA SCANDINAVICA, 50.
Vancouver
1.
Hendriksen RS, Mevius DJ, Schroeter A, Teale C, Jouy E, Butaye P, et al. Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002-2004: the ARBAO-II study. ACTA VETERINARIA SCANDINAVICA. 2008;50.
MLA
Hendriksen, Rene S, Dik J Mevius, Andreas Schroeter, et al. “Occurrence of Antimicrobial Resistance Among Bacterial Pathogens and Indicator Bacteria in Pigs in Different European Countries from Year 2002-2004: The ARBAO-II Study.” ACTA VETERINARIA SCANDINAVICA 50 (2008): n. pag. Print.