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Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling

Marie Huysman, Cindy Martens UGent, Klaas Vandepoele UGent, Jeroen Gillard UGent, Edda Rayko, Marc Heijde UGent, Chris Bowler, Dirk Inzé UGent, Yves Van de Peer UGent, Lieven De Veylder UGent, et al. (2010) GENOME BIOLOGY. 11(2).
abstract
Background : Despite the enormous importance of diatoms in aquatic ecosystems and their broad industrial potential, little is known about their life cycle control. Diatoms typically inhabit rapidly changing and unstable environments, suggesting that cell cycle regulation in diatoms must have evolved to adequately integrate various environmental signals. The recent genome sequencing of Thalassiosira pseudonana and Phaeodactylum tricornutum allows us to explore the molecular conservation of cell cycle regulation in diatoms. Results : By profile-based annotation of cell cycle genes, counterparts of conserved as well as new regulators were identified in T. pseudonana and P. tricornutum. In particular, the cyclin gene family was found to be expanded extensively compared to that of other eukaryotes and a novel type of cyclins was discovered, the diatom-specific cyclins. We established a synchronization method for P. tricornutum that enabled assignment of the different annotated genes to specific cell cycle phase transitions. The diatom-specific cyclins are predominantly expressed at the G1-to-S transition and some respond to phosphate availability, hinting at a role in connecting cell division to environmental stimuli. Conclusion : The discovery of highly conserved and new cell cycle regulators suggests the evolution of unique control mechanisms for diatom cell division, probably contributing to their ability to adapt and survive under highly fluctuating environmental conditions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DEPENDENT PROTEIN-KINASE, ARABIDOPSIS-THALIANA, PHOSPHORYLATES CDC2, THEILERIA-PARVA, MARINE DIATOMS, NITRIC-OXIDE, THALASSIOSIRA-PSEUDONANA, CHLAMYDOMONAS-REINHARDTII, PHAEODACTYLUM-TRICORNUTUM, CDK-ACTIVATING KINASE
journal title
GENOME BIOLOGY
Genome Biol.
volume
11
issue
2
article number
R17
pages
19 pages
Web of Science type
Article
Web of Science id
000276434300009
ISSN
1474-760X
DOI
10.1186/gb-2010-11-2-r17
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
920805
handle
http://hdl.handle.net/1854/LU-920805
date created
2010-04-03 22:46:01
date last changed
2018-03-01 10:32:16
@article{920805,
  abstract     = {Background : Despite the enormous importance of diatoms in aquatic ecosystems and their broad industrial potential, little is known about their life cycle control. Diatoms typically inhabit rapidly changing and unstable environments, suggesting that cell cycle regulation in diatoms must have evolved to adequately integrate various environmental signals. The recent genome sequencing of Thalassiosira pseudonana and Phaeodactylum tricornutum allows us to explore the molecular conservation of cell cycle regulation in diatoms.
Results : By profile-based annotation of cell cycle genes, counterparts of conserved as well as new regulators were identified in T. pseudonana and P. tricornutum. In particular, the cyclin gene family was found to be expanded extensively compared to that of other eukaryotes and a novel type of cyclins was discovered, the diatom-specific cyclins. We established a synchronization method for P. tricornutum that enabled assignment of the different annotated genes to specific cell cycle phase transitions. The diatom-specific cyclins are predominantly expressed at the G1-to-S transition and some respond to phosphate availability, hinting at a role in connecting cell division to environmental stimuli.
Conclusion : The discovery of highly conserved and new cell cycle regulators suggests the evolution of unique control mechanisms for diatom cell division, probably contributing to their ability to adapt and survive under highly fluctuating environmental conditions.},
  articleno    = {R17},
  author       = {Huysman, Marie and Martens, Cindy and Vandepoele, Klaas and Gillard, Jeroen and Rayko, Edda and Heijde, Marc and Bowler, Chris and Inz{\'e}, Dirk and Van de Peer, Yves and De Veylder, Lieven and Vyverman, Wim},
  issn         = {1474-760X},
  journal      = {GENOME BIOLOGY},
  keyword      = {DEPENDENT PROTEIN-KINASE,ARABIDOPSIS-THALIANA,PHOSPHORYLATES CDC2,THEILERIA-PARVA,MARINE DIATOMS,NITRIC-OXIDE,THALASSIOSIRA-PSEUDONANA,CHLAMYDOMONAS-REINHARDTII,PHAEODACTYLUM-TRICORNUTUM,CDK-ACTIVATING KINASE},
  language     = {eng},
  number       = {2},
  pages        = {19},
  title        = {Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling},
  url          = {http://dx.doi.org/10.1186/gb-2010-11-2-r17},
  volume       = {11},
  year         = {2010},
}

Chicago
Huysman, Marie, Cindy Martens, Klaas Vandepoele, Jeroen Gillard, Edda Rayko, Marc Heijde, Chris Bowler, et al. 2010. “Genome-wide Analysis of the Diatom Cell Cycle Unveils a Novel Type of Cyclins Involved in Environmental Signaling.” Genome Biology 11 (2).
APA
Huysman, M., Martens, C., Vandepoele, K., Gillard, J., Rayko, E., Heijde, M., Bowler, C., et al. (2010). Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling. GENOME BIOLOGY, 11(2).
Vancouver
1.
Huysman M, Martens C, Vandepoele K, Gillard J, Rayko E, Heijde M, et al. Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling. GENOME BIOLOGY. 2010;11(2).
MLA
Huysman, Marie, Cindy Martens, Klaas Vandepoele, et al. “Genome-wide Analysis of the Diatom Cell Cycle Unveils a Novel Type of Cyclins Involved in Environmental Signaling.” GENOME BIOLOGY 11.2 (2010): n. pag. Print.