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Role of the pseudorabies virus US3 protein kinase in the evasion of antiviral host responses during infection

Matthias Deruelle UGent (2010)
abstract
A typical characteristic of herpesviruses is that they achieve lifelong persistence in the infected host by establishing latency from which the virus can reactivate upon specific stimuli. Reactivation may lead to spread of infectious virus and the occurrence of disease symptoms. In order to be able to spread in immune-competent hosts during reactivation periods, herpesviruses have developed diverse strategies to avoid or delay antiviral host responses, thus enabling the virus to replicate, spread, and transmit to other hosts. The aim of this thesis was to study the potential of the multifunctional US3 serine/threonine kinase of the porcine alphaherpesvirus pseudorabies virus (PRV) to interfere with three aspects of the antiviral defense of the host: (i) apoptosis of infected cells, an intrinsic cellular antiviral response, (ii) the antiviral effect of type I interferon (IFN), an innate antiviral response, and (iii) MHC I-mediated antigen presentation, a key component in the adaptive antiviral response.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
keyword
interferon-alpha, apoptosis, immuno-evasion, US3 protein kinase, pseudorabies virus, alphaherpesvirus, MHC I
pages
V, 205 pages
publisher
Ghent University. Faculty of Veterinary Medicine
place of publication
Merelbeke, Belgium
defense location
Merelbeke : Faculteit Diergeneeskunde (auditorium D)
defense date
2010-03-29 16:30
ISBN
9789058642066
language
English
UGent publication?
yes
classification
D1
additional info
dissertation in parts contains copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
920454
handle
http://hdl.handle.net/1854/LU-920454
date created
2010-04-02 09:35:17
date last changed
2010-04-22 12:10:35
@phdthesis{920454,
  abstract     = {A typical characteristic of herpesviruses is that they achieve lifelong persistence in the infected host by establishing latency from which the virus can reactivate upon specific stimuli. Reactivation may lead to spread of infectious virus and the occurrence of disease symptoms. In order to be able to spread in immune-competent hosts during reactivation periods, herpesviruses have developed diverse strategies to avoid or delay antiviral host responses, thus enabling the virus to replicate, spread, and transmit to other hosts.
The aim of this thesis was to study the potential of the multifunctional US3 serine/threonine kinase of the porcine alphaherpesvirus pseudorabies virus (PRV) to interfere with three aspects of the antiviral defense of the host: (i) apoptosis of infected cells, an intrinsic cellular antiviral response, (ii) the antiviral effect of type I interferon (IFN), an innate antiviral response, and (iii) MHC I-mediated antigen presentation, a key component in the adaptive antiviral response.},
  author       = {Deruelle, Matthias},
  isbn         = {9789058642066},
  keyword      = {interferon-alpha,apoptosis,immuno-evasion,US3 protein kinase,pseudorabies virus,alphaherpesvirus,MHC I},
  language     = {eng},
  pages        = {V, 205},
  publisher    = {Ghent University. Faculty of Veterinary Medicine},
  school       = {Ghent University},
  title        = {Role of the pseudorabies virus US3 protein kinase in the evasion of antiviral host responses during infection},
  year         = {2010},
}

Chicago
Deruelle, Matthias. 2010. “Role of the Pseudorabies Virus US3 Protein Kinase in the Evasion of Antiviral Host Responses During Infection”. Merelbeke, Belgium: Ghent University. Faculty of Veterinary Medicine.
APA
Deruelle, M. (2010). Role of the pseudorabies virus US3 protein kinase in the evasion of antiviral host responses during infection. Ghent University. Faculty of Veterinary Medicine, Merelbeke, Belgium.
Vancouver
1.
Deruelle M. Role of the pseudorabies virus US3 protein kinase in the evasion of antiviral host responses during infection. [Merelbeke, Belgium]: Ghent University. Faculty of Veterinary Medicine; 2010.
MLA
Deruelle, Matthias. “Role of the Pseudorabies Virus US3 Protein Kinase in the Evasion of Antiviral Host Responses During Infection.” 2010 : n. pag. Print.