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Concentration of penicillin G in mammary tissue and secretion of end-term dairy heifers following systemic prepartum administration of penethamate hydriodide

(2010) JOURNAL OF DAIRY RESEARCH. 77(1). p.33-36
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Abstract
The aim of this study was to assess the concentration of penicillin G in mammary tissue and secretion of dry heifers following systemic administration of penethamate hydriodide. Six dairy heifers in late gestation received a single intramuscular injection of 10 g penethamate hydriodide and were sacrificed 24, 48 or 144 h after treatment. Penicillin G concentrations were measured in mammary tissue and secretion samples using HPLC. Penicillin G was detected in the Udder of two animals euthanized at 24 h (mammary tissue and secretion) and at 48 h post treatment (mammary secretion only) after administration at concentrations still close to or above MIC90 values reported for the pathogens associated with heifer mastitis. Antibiotic concentration shortly after administration will have been Substantially higher indicating a potential for systemic treatment with penethamate hydriodide to control prepartum intramammary infections in heifers without the disadvantages of local therapy Such as teat contamination or risk of trauma for the administrator.
Keywords
penethamate hydriodide, Dairy heifer, IMPACT, prepartum treatment, systemic, SOMATIC-CELL COUNT, EARLY LACTATION, INTRAMAMMARY INFECTIONS, CLINICAL MASTITIS, 1ST LACTATION, UDDER HEALTH, MILK-YIELD, COWS, PREVALENCE

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Chicago
Passchyn, Pieter, Sofie Piepers, Ellen Schmitt-Van de leemput, Christian Guidarini, and Sarne De Vliegher. 2010. “Concentration of Penicillin G in Mammary Tissue and Secretion of End-term Dairy Heifers Following Systemic Prepartum Administration of Penethamate Hydriodide.” Journal of Dairy Research 77 (1): 33–36.
APA
Passchyn, P., Piepers, S., Schmitt-Van de leemput, E., Guidarini, C., & De Vliegher, S. (2010). Concentration of penicillin G in mammary tissue and secretion of end-term dairy heifers following systemic prepartum administration of penethamate hydriodide. JOURNAL OF DAIRY RESEARCH, 77(1), 33–36.
Vancouver
1.
Passchyn P, Piepers S, Schmitt-Van de leemput E, Guidarini C, De Vliegher S. Concentration of penicillin G in mammary tissue and secretion of end-term dairy heifers following systemic prepartum administration of penethamate hydriodide. JOURNAL OF DAIRY RESEARCH. 2010;77(1):33–6.
MLA
Passchyn, Pieter, Sofie Piepers, Ellen Schmitt-Van de leemput, et al. “Concentration of Penicillin G in Mammary Tissue and Secretion of End-term Dairy Heifers Following Systemic Prepartum Administration of Penethamate Hydriodide.” JOURNAL OF DAIRY RESEARCH 77.1 (2010): 33–36. Print.
@article{914658,
  abstract     = {The aim of this study was to assess the concentration of penicillin G in mammary tissue and secretion of dry heifers following systemic administration of penethamate hydriodide. Six dairy heifers in late gestation received a single intramuscular injection of 10 g penethamate hydriodide and were sacrificed 24, 48 or 144 h after treatment. Penicillin G concentrations were measured in mammary tissue and secretion samples using HPLC. Penicillin G was detected in the Udder of two animals euthanized at 24 h (mammary tissue and secretion) and at 48 h post treatment (mammary secretion only) after administration at concentrations still close to or above MIC90 values reported for the pathogens associated with heifer mastitis. Antibiotic concentration shortly after administration will have been Substantially higher indicating a potential for systemic treatment with penethamate hydriodide to control prepartum intramammary infections in heifers without the disadvantages of local therapy Such as teat contamination or risk of trauma for the administrator.},
  author       = {Passchyn, Pieter and Piepers, Sofie and Schmitt-Van de leemput, Ellen and Guidarini, Christian and De Vliegher, Sarne},
  issn         = {0022-0299},
  journal      = {JOURNAL OF DAIRY RESEARCH},
  keyword      = {penethamate hydriodide,Dairy heifer,IMPACT,prepartum treatment,systemic,SOMATIC-CELL COUNT,EARLY LACTATION,INTRAMAMMARY INFECTIONS,CLINICAL MASTITIS,1ST LACTATION,UDDER HEALTH,MILK-YIELD,COWS,PREVALENCE},
  language     = {eng},
  number       = {1},
  pages        = {33--36},
  title        = {Concentration of penicillin G in mammary tissue and secretion of end-term dairy heifers following systemic prepartum administration of penethamate hydriodide},
  url          = {http://dx.doi.org/10.1017/S0022029909990288},
  volume       = {77},
  year         = {2010},
}

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