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Importance of using complementary process analyzers for the process monitoring, analysis, and understanding of freeze drying

Thomas De Beer UGent, M Wiggenhorn, R Veillon, C Debacq, Y Mayeresse, B Moreau, Anneleen Burggraeve UGent, Thomas Quinten UGent, W Friess and G Winter, et al. (2009) ANALYTICAL CHEMISTRY. 81(18). p.7639-7649
abstract
The aim of the present paper is to demonstrate the importance of using complementary process analyzers (PAT tools) for the process monitoring, analysis, and understanding of freeze drying. A mannitol solution was used as a model system. Raman spectroscopic, near-infrared (NIR) spectroscopic, plasma emission spectroscopic, and wireless temperature measurements (TEM-PRIS) were simultaneously performed in-line and real-time during each freeze-drying experiment. The combination of these four process analyzers to monitor a freeze-drying process is unique. The Raman and NIR data were analyzed using principal component analysis (PCA) and multivariate curve resolution (MCR), while the plasma emission spectroscopic and wireless temperature measurement data were analyzed using univariate data analysis. It was shown that the considered process analyzers do not only complement but also mutually confirm each other with respect to process step end points, physical phenomena occurring during freeze drying (process understanding), and product characterization (solid state). Furthermore and most important, the combined use of the process analyzers helped to identify flaws in previous studies in which these process analyzers were studied individually. Process analyzers might wrongly indicate that some process steps are fulfilled. Finally, combining the studied process analyzers also showed that more information per process analyzer can be obtained than previously described. A combination of Raman and plasma emission spectroscopy seems favorable for the monitoring of nearly all critical freeze-drying process aspects.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
NEAR-INFRARED SPECTROSCOPY, MANNITOL, DIFFERENTIATION, FORMULATIONS, SURFACE, HYDRATE, SYSTEM, WATER
journal title
ANALYTICAL CHEMISTRY
Anal. Chem.
volume
81
issue
18
pages
11 pages
Web of Science type
Article
Web of Science id
000269656700017
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
5.214 (2009)
JCR rank
3/70 (2009)
JCR quartile
1 (2009)
ISSN
0003-2700
DOI
10.1021/ac9010414
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
912700
handle
http://hdl.handle.net/1854/LU-912700
date created
2010-03-25 10:02:12
date last changed
2010-04-08 14:08:58
@article{912700,
  abstract     = {The aim of the present paper is to demonstrate the importance of using complementary process analyzers (PAT tools) for the process monitoring, analysis, and understanding of freeze drying. A mannitol solution was used as a model system. Raman spectroscopic, near-infrared (NIR) spectroscopic, plasma emission spectroscopic, and wireless temperature measurements (TEM-PRIS) were simultaneously performed in-line and real-time during each freeze-drying experiment. The combination of these four process analyzers to monitor a freeze-drying process is unique. The Raman and NIR data were analyzed using principal component analysis (PCA) and multivariate curve resolution (MCR), while the plasma emission spectroscopic and wireless temperature measurement data were analyzed using univariate data analysis. It was shown that the considered process analyzers do not only complement but also mutually confirm each other with respect to process step end points, physical phenomena occurring during freeze drying (process understanding), and product characterization (solid state). Furthermore and most important, the combined use of the process analyzers helped to identify flaws in previous studies in which these process analyzers were studied individually. Process analyzers might wrongly indicate that some process steps are fulfilled. Finally, combining the studied process analyzers also showed that more information per process analyzer can be obtained than previously described. A combination of Raman and plasma emission spectroscopy seems favorable for the monitoring of nearly all critical freeze-drying process aspects.},
  author       = {De Beer, Thomas and Wiggenhorn, M and Veillon, R and Debacq, C and Mayeresse, Y and Moreau, B and Burggraeve, Anneleen and Quinten, Thomas and Friess, W and Winter, G and Vervaet, Chris and Remon, Jean Paul and Baeyens, Willy},
  issn         = {0003-2700},
  journal      = {ANALYTICAL CHEMISTRY},
  keyword      = {NEAR-INFRARED SPECTROSCOPY,MANNITOL,DIFFERENTIATION,FORMULATIONS,SURFACE,HYDRATE,SYSTEM,WATER},
  language     = {eng},
  number       = {18},
  pages        = {7639--7649},
  title        = {Importance of using complementary process analyzers for the process monitoring, analysis, and understanding of freeze drying},
  url          = {http://dx.doi.org/10.1021/ac9010414},
  volume       = {81},
  year         = {2009},
}

Chicago
De Beer, Thomas, M Wiggenhorn, R Veillon, C Debacq, Y Mayeresse, B Moreau, Anneleen Burggraeve, et al. 2009. “Importance of Using Complementary Process Analyzers for the Process Monitoring, Analysis, and Understanding of Freeze Drying.” Analytical Chemistry 81 (18): 7639–7649.
APA
De Beer, T., Wiggenhorn, M., Veillon, R., Debacq, C., Mayeresse, Y., Moreau, B., Burggraeve, A., et al. (2009). Importance of using complementary process analyzers for the process monitoring, analysis, and understanding of freeze drying. ANALYTICAL CHEMISTRY, 81(18), 7639–7649.
Vancouver
1.
De Beer T, Wiggenhorn M, Veillon R, Debacq C, Mayeresse Y, Moreau B, et al. Importance of using complementary process analyzers for the process monitoring, analysis, and understanding of freeze drying. ANALYTICAL CHEMISTRY. 2009;81(18):7639–49.
MLA
De Beer, Thomas, M Wiggenhorn, R Veillon, et al. “Importance of Using Complementary Process Analyzers for the Process Monitoring, Analysis, and Understanding of Freeze Drying.” ANALYTICAL CHEMISTRY 81.18 (2009): 7639–7649. Print.