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Broad-spectrum β-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health

Annemieke Smet UGent, An Martel UGent, Davy Persoons UGent, Jeroen Dewulf UGent, Marc Heyndrickx, Lieve Herman, Freddy Haesebrouck UGent and Patrick Butaye UGent (2010) FEMS MICROBIOLOGY REVIEWS. 34(3). p.295-316
abstract
Broad-spectrum β-lactamase genes (coding for extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases) have been frequently demonstrated in the microbiota of food-producing animals. This may pose a human health hazard since these genes may be present in zoonotic bacteria, which would cause a direct problem. They can also be present in commensals, which may act as a reservoir of resistance genes for pathogens causing disease both in humans and animals. Broad-spectrum β-lactamase genes are frequently located on mobile genetic elements, such as plasmids, transposons and integrons, which often also carry additional resistance genes. This could limit treatment options for infections caused by broad-spectrum β-lactam-resistant microorganisms. This review addresses the growing burden of broad-spectrum β-lactam resistance among Enterobacteriaceae isolated from food, companion and wild animals worldwide. To explore the human health hazard, the diversity of broad-spectrum β-lactamases among Enterobacteriaceae derived from animals is compared with respect to their presence in human bacteria. Furthermore, the possibilities of the exchange of genes encoding broad-spectrum β-lactamases – including the exchange of the transposons and plasmids that serve as vehicles for these genes – between different ecosystems (human and animal) are discussed.
Please use this url to cite or link to this publication:
author
organization
alternative title
Broad-spectrum beta-lactamases among Enterobacteriaceae of animal origin : molecular aspects, mobility and impact on public health
year
type
journalArticle (review)
publication status
published
subject
keyword
ANTIMICROBIAL RESISTANCE, FECAL CARRIAGE, CLASS-1 INTEGRON, PROTEUS-MIRABILIS, CTX-M, SALMONELLA-ENTERICA STRAINS, COMPLETE NUCLEOTIDE-SEQUENCE, KLEBSIELLA-PNEUMONIAE STRAINS, ESCHERICHIA-COLI STRAINS, beta-lactamases, mobile genetic elements, human health hazard, FOOD ANIMALS
journal title
FEMS MICROBIOLOGY REVIEWS
FEMS Microbiol. Rev.
volume
34
issue
3
pages
295 - 316
Web of Science type
Review
Web of Science id
000276246300004
JCR category
MICROBIOLOGY
JCR impact factor
11.796 (2010)
JCR rank
6/103 (2010)
JCR quartile
1 (2010)
ISSN
0168-6445
DOI
10.1111/j.1574-6976.2009.00198.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
910573
handle
http://hdl.handle.net/1854/LU-910573
date created
2010-03-23 10:53:08
date last changed
2011-06-21 16:03:58
@article{910573,
  abstract     = {Broad-spectrum \ensuremath{\beta}-lactamase genes (coding for extended-spectrum \ensuremath{\beta}-lactamases (ESBLs) and AmpC \ensuremath{\beta}-lactamases) have been frequently demonstrated in the microbiota of food-producing animals. This may pose a human health hazard since these genes may be present in zoonotic bacteria, which would cause a direct problem. They can also be present in commensals, which may act as a reservoir of resistance genes for pathogens causing disease both in humans and animals. 
Broad-spectrum \ensuremath{\beta}-lactamase genes are frequently located on mobile genetic elements, such as plasmids, transposons and integrons, which often also carry additional resistance genes. This could limit treatment options for infections caused by broad-spectrum \ensuremath{\beta}-lactam-resistant microorganisms. This review addresses the growing burden of broad-spectrum \ensuremath{\beta}-lactam resistance among Enterobacteriaceae isolated from food, companion and wild animals worldwide. To explore the human health hazard, the diversity of broad-spectrum \ensuremath{\beta}-lactamases among Enterobacteriaceae derived from animals is compared with respect to their presence in human bacteria. Furthermore, the possibilities of the exchange of genes encoding broad-spectrum \ensuremath{\beta}-lactamases -- including the exchange of the transposons and plasmids that serve as vehicles for these genes -- between different ecosystems (human and animal) are discussed.},
  author       = {Smet, Annemieke and Martel, An and Persoons, Davy and Dewulf, Jeroen and Heyndrickx, Marc and Herman, Lieve  and Haesebrouck, Freddy and Butaye, Patrick},
  issn         = {0168-6445},
  journal      = {FEMS MICROBIOLOGY REVIEWS},
  keyword      = {ANTIMICROBIAL RESISTANCE,FECAL CARRIAGE,CLASS-1 INTEGRON,PROTEUS-MIRABILIS,CTX-M,SALMONELLA-ENTERICA STRAINS,COMPLETE NUCLEOTIDE-SEQUENCE,KLEBSIELLA-PNEUMONIAE STRAINS,ESCHERICHIA-COLI STRAINS,beta-lactamases,mobile genetic elements,human health hazard,FOOD ANIMALS},
  language     = {eng},
  number       = {3},
  pages        = {295--316},
  title        = {Broad-spectrum \ensuremath{\beta}-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health},
  url          = {http://dx.doi.org/10.1111/j.1574-6976.2009.00198.x},
  volume       = {34},
  year         = {2010},
}

Chicago
Smet, Annemieke, An Martel, Davy Persoons, Jeroen Dewulf, Marc Heyndrickx, Lieve Herman, Freddy Haesebrouck, and Patrick Butaye. 2010. “Broad-spectrum Β-lactamases Among Enterobacteriaceae of Animal Origin: Molecular Aspects, Mobility and Impact on Public Health.” Fems Microbiology Reviews 34 (3): 295–316.
APA
Smet, A., Martel, A., Persoons, D., Dewulf, J., Heyndrickx, M., Herman, L., Haesebrouck, F., et al. (2010). Broad-spectrum β-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health. FEMS MICROBIOLOGY REVIEWS, 34(3), 295–316.
Vancouver
1.
Smet A, Martel A, Persoons D, Dewulf J, Heyndrickx M, Herman L, et al. Broad-spectrum β-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health. FEMS MICROBIOLOGY REVIEWS. 2010;34(3):295–316.
MLA
Smet, Annemieke, An Martel, Davy Persoons, et al. “Broad-spectrum Β-lactamases Among Enterobacteriaceae of Animal Origin: Molecular Aspects, Mobility and Impact on Public Health.” FEMS MICROBIOLOGY REVIEWS 34.3 (2010): 295–316. Print.