Ghent University Academic Bibliography

Advanced

Replacing vascular corrosion casting by in-vivo micro-CT imaging for building 3D cardiovascular models in mice

Bert Vandeghinste UGent, Bram Trachet UGent, Marjolijn Renard UGent, Christophe Casteleyn UGent, Steven Staelens UGent, Bart Loeys UGent, Patrick Segers UGent and Stefaan Vandenberghe UGent (2011) MOLECULAR IMAGING AND BIOLOGY. 13(1). p.78-86
abstract
The purpose of this study was to investigate if in vivo micro-computed tomography (CT) is a reliable alternative to micro-CT scanning of a vascular corrosion cast. This would allow one to study the early development of cardiovascular diseases. Datasets using both modalities were acquired, segmented, and used to generate a 3D geometrical model from nine mice. As blood pool contrast agent, Fenestra VC-131 was used. Batson's No. 17 was used as casting agent. Computational fluid dynamics simulations were performed on both datasets to quantify the difference in wall shear stress (WSS). Aortic arch diameters show 30% to 40% difference between the Fenestra VC-131 and the casted dataset. The aortic arch bifurcation angles show less than 20% difference between both datasets. Numerically computed WSS showed a 28% difference between both datasets. Our results indicate that in vivo micro-CT imaging can provide an excellent alternative for vascular corrosion casting. This enables follow-up studies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Vascular corrosion casting, 3D model, Mice, Micro-CT, In vivo, Fenestra, ANEURYSM, HEMODYNAMICS, MARFAN-SYNDROME, ATHEROSCLEROTIC LESIONS, MOUSE AORTIC-ARCH, Wall shear stress, FREE-BREATHING RODENTS, WALL SHEAR-STRESS
journal title
MOLECULAR IMAGING AND BIOLOGY
Mol. Imaging. Biol.
volume
13
issue
1
pages
78 - 86
Web of Science type
Article
Web of Science id
000286395600011
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
3.844 (2011)
JCR rank
14/116 (2011)
JCR quartile
1 (2011)
ISSN
1536-1632
DOI
10.1007/s11307-010-0335-8
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
910235
handle
http://hdl.handle.net/1854/LU-910235
date created
2010-03-22 15:47:14
date last changed
2013-02-27 09:08:14
@article{910235,
  abstract     = {The purpose of this study was to investigate if in vivo micro-computed tomography (CT) is a reliable alternative to micro-CT scanning of a vascular corrosion cast. This would allow one to study the early development of cardiovascular diseases.
Datasets using both modalities were acquired, segmented, and used to generate a 3D geometrical model from nine mice. As blood pool contrast agent, Fenestra VC-131 was used. Batson's No. 17 was used as casting agent. Computational fluid dynamics simulations were performed on both datasets to quantify the difference in wall shear stress (WSS).
Aortic arch diameters show 30\% to 40\% difference between the Fenestra VC-131 and the casted dataset. The aortic arch bifurcation angles show less than 20\% difference between both datasets. Numerically computed WSS showed a 28\% difference between both datasets.
Our results indicate that in vivo micro-CT imaging can provide an excellent alternative for vascular corrosion casting. This enables follow-up studies.},
  author       = {Vandeghinste, Bert and Trachet, Bram and Renard, Marjolijn and Casteleyn, Christophe and Staelens, Steven and Loeys, Bart and Segers, Patrick and Vandenberghe, Stefaan},
  issn         = {1536-1632},
  journal      = {MOLECULAR IMAGING AND BIOLOGY},
  keyword      = {Vascular corrosion casting,3D model,Mice,Micro-CT,In vivo,Fenestra,ANEURYSM,HEMODYNAMICS,MARFAN-SYNDROME,ATHEROSCLEROTIC LESIONS,MOUSE AORTIC-ARCH,Wall shear stress,FREE-BREATHING RODENTS,WALL SHEAR-STRESS},
  language     = {eng},
  number       = {1},
  pages        = {78--86},
  title        = {Replacing vascular corrosion casting by in-vivo micro-CT imaging for building 3D cardiovascular models in mice},
  url          = {http://dx.doi.org/10.1007/s11307-010-0335-8},
  volume       = {13},
  year         = {2011},
}

Chicago
Vandeghinste, Bert, Bram Trachet, Marjolijn Renard, Christophe Casteleyn, Steven Staelens, Bart Loeys, Patrick Segers, and Stefaan Vandenberghe. 2011. “Replacing Vascular Corrosion Casting by In-vivo micro-CT Imaging for Building 3D Cardiovascular Models in Mice.” Molecular Imaging and Biology 13 (1): 78–86.
APA
Vandeghinste, B., Trachet, B., Renard, M., Casteleyn, C., Staelens, S., Loeys, B., Segers, P., et al. (2011). Replacing vascular corrosion casting by in-vivo micro-CT imaging for building 3D cardiovascular models in mice. MOLECULAR IMAGING AND BIOLOGY, 13(1), 78–86.
Vancouver
1.
Vandeghinste B, Trachet B, Renard M, Casteleyn C, Staelens S, Loeys B, et al. Replacing vascular corrosion casting by in-vivo micro-CT imaging for building 3D cardiovascular models in mice. MOLECULAR IMAGING AND BIOLOGY. 2011;13(1):78–86.
MLA
Vandeghinste, Bert, Bram Trachet, Marjolijn Renard, et al. “Replacing Vascular Corrosion Casting by In-vivo micro-CT Imaging for Building 3D Cardiovascular Models in Mice.” MOLECULAR IMAGING AND BIOLOGY 13.1 (2011): 78–86. Print.