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Replacing vascular corrosion casting by in-vivo micro-CT imaging for building 3D cardiovascular models in mice

Bert Vandeghinste (UGent) , Bram Trachet (UGent) , Marjolijn Renard (UGent) , Christophe Casteleyn (UGent) , Steven Staelens (UGent) , Bart Loeys (UGent) , Patrick Segers (UGent) and Stefaan Vandenberghe (UGent)
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
The purpose of this study was to investigate if in vivo micro-computed tomography (CT) is a reliable alternative to micro-CT scanning of a vascular corrosion cast. This would allow one to study the early development of cardiovascular diseases. Datasets using both modalities were acquired, segmented, and used to generate a 3D geometrical model from nine mice. As blood pool contrast agent, Fenestra VC-131 was used. Batson's No. 17 was used as casting agent. Computational fluid dynamics simulations were performed on both datasets to quantify the difference in wall shear stress (WSS). Aortic arch diameters show 30% to 40% difference between the Fenestra VC-131 and the casted dataset. The aortic arch bifurcation angles show less than 20% difference between both datasets. Numerically computed WSS showed a 28% difference between both datasets. Our results indicate that in vivo micro-CT imaging can provide an excellent alternative for vascular corrosion casting. This enables follow-up studies.
Keywords
Vascular corrosion casting, 3D model, Mice, Micro-CT, In vivo, Fenestra, ANEURYSM, HEMODYNAMICS, MARFAN-SYNDROME, ATHEROSCLEROTIC LESIONS, MOUSE AORTIC-ARCH, Wall shear stress, FREE-BREATHING RODENTS, WALL SHEAR-STRESS

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Citation

Please use this url to cite or link to this publication:

MLA
Vandeghinste, Bert et al. “Replacing Vascular Corrosion Casting by In-vivo micro-CT Imaging for Building 3D Cardiovascular Models in Mice.” MOLECULAR IMAGING AND BIOLOGY 13.1 (2011): 78–86. Print.
APA
Vandeghinste, B., Trachet, B., Renard, M., Casteleyn, C., Staelens, S., Loeys, B., Segers, P., et al. (2011). Replacing vascular corrosion casting by in-vivo micro-CT imaging for building 3D cardiovascular models in mice. MOLECULAR IMAGING AND BIOLOGY, 13(1), 78–86.
Chicago author-date
Vandeghinste, Bert, Bram Trachet, Marjolijn Renard, Christophe Casteleyn, Steven Staelens, Bart Loeys, Patrick Segers, and Stefaan Vandenberghe. 2011. “Replacing Vascular Corrosion Casting by In-vivo micro-CT Imaging for Building 3D Cardiovascular Models in Mice.” Molecular Imaging and Biology 13 (1): 78–86.
Chicago author-date (all authors)
Vandeghinste, Bert, Bram Trachet, Marjolijn Renard, Christophe Casteleyn, Steven Staelens, Bart Loeys, Patrick Segers, and Stefaan Vandenberghe. 2011. “Replacing Vascular Corrosion Casting by In-vivo micro-CT Imaging for Building 3D Cardiovascular Models in Mice.” Molecular Imaging and Biology 13 (1): 78–86.
Vancouver
1.
Vandeghinste B, Trachet B, Renard M, Casteleyn C, Staelens S, Loeys B, et al. Replacing vascular corrosion casting by in-vivo micro-CT imaging for building 3D cardiovascular models in mice. MOLECULAR IMAGING AND BIOLOGY. 2011;13(1):78–86.
IEEE
[1]
B. Vandeghinste et al., “Replacing vascular corrosion casting by in-vivo micro-CT imaging for building 3D cardiovascular models in mice,” MOLECULAR IMAGING AND BIOLOGY, vol. 13, no. 1, pp. 78–86, 2011.
@article{910235,
  abstract     = {The purpose of this study was to investigate if in vivo micro-computed tomography (CT) is a reliable alternative to micro-CT scanning of a vascular corrosion cast. This would allow one to study the early development of cardiovascular diseases.
Datasets using both modalities were acquired, segmented, and used to generate a 3D geometrical model from nine mice. As blood pool contrast agent, Fenestra VC-131 was used. Batson's No. 17 was used as casting agent. Computational fluid dynamics simulations were performed on both datasets to quantify the difference in wall shear stress (WSS).
Aortic arch diameters show 30% to 40% difference between the Fenestra VC-131 and the casted dataset. The aortic arch bifurcation angles show less than 20% difference between both datasets. Numerically computed WSS showed a 28% difference between both datasets.
Our results indicate that in vivo micro-CT imaging can provide an excellent alternative for vascular corrosion casting. This enables follow-up studies.},
  author       = {Vandeghinste, Bert and Trachet, Bram and Renard, Marjolijn and Casteleyn, Christophe and Staelens, Steven and Loeys, Bart and Segers, Patrick and Vandenberghe, Stefaan},
  issn         = {1536-1632},
  journal      = {MOLECULAR IMAGING AND BIOLOGY},
  keywords     = {Vascular corrosion casting,3D model,Mice,Micro-CT,In vivo,Fenestra,ANEURYSM,HEMODYNAMICS,MARFAN-SYNDROME,ATHEROSCLEROTIC LESIONS,MOUSE AORTIC-ARCH,Wall shear stress,FREE-BREATHING RODENTS,WALL SHEAR-STRESS},
  language     = {eng},
  number       = {1},
  pages        = {78--86},
  title        = {Replacing vascular corrosion casting by in-vivo micro-CT imaging for building 3D cardiovascular models in mice},
  url          = {http://dx.doi.org/10.1007/s11307-010-0335-8},
  volume       = {13},
  year         = {2011},
}

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