Advanced search
1 file | 247.22 KB

A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the GRACE genetics study

(2010) EUROPEAN HEART JOURNAL. 31(9). p.1132-1141
Author
Organization
Abstract
Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI). Here, we evaluated whether this variant also contributes to recurrent MI or cardiac death following an acute coronary syndrome (ACS). A total of 3247 patients with ACS enrolled in the Global Registry of Acute Coronary Events (GRACE) in three distinct populations (UK, Belgium and Poland) were prospectively followed for 6 months and genotyped for rs1333049, in addition to 3004 and 2467 healthy controls from the UK and Belgium. After having confirmed that the at-risk C allele of rs1333049 was associated with index ACS in the UK and Belgian populations, we found that the rs1333049 at-risk C allele was significantly and independently associated with recurrent MI [age- and gender-adjusted hazard ratio (HR) 1.48, CI = 1.00-2.19, P = 0.048; and multivariable-adjusted HR 1.47, CI = 0.99-2.18; P = 0.053] and with recurrent MI or cardiac death (age- and gender-adjusted HR 1.58, CI = 1.00-2.48; P = 0.045; and multivariable adjusted HR 1.49, CI = 1.03-1.98; P = 0.028) within 6 months after an index ACS. Inclusion of rs1333049 into the GRACE risk score significantly improved classification for recurrent MI or cardiac death (P = 0.040), as calculated by the integrated discrimination improvement method. In this large observational study, the 9p21 variant was independently associated with adverse cardiac outcome after ACS.
Keywords
Rs1333049, Chromosome 9p21, Genetics, ARTERY-DISEASE, METAANALYSIS, RISK, SUSCEPTIBILITY, PREDICTORS, RATIONALE, EVENTS, DESIGN, LOCUS, Myocardial infarction, Plaque rupture, Acute coronary syndrome

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 247.22 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Buysschaert, Ian , Kathryn F Carruthers, Donald R Dunbar, Gilian Peuteman, Ernst Rietzschel, Ann Belmans, Ann Hedley, et al. 2010. “A Variant at Chromosome 9p21 Is Associated with Recurrent Myocardial Infarction and Cardiac Death After Acute Coronary Syndrome: The GRACE Genetics Study.” European Heart Journal 31 (9): 1132–1141.
APA
Buysschaert, I., Carruthers, K. F., Dunbar, D. R., Peuteman, G., Rietzschel, E., Belmans, A., Hedley, A., et al. (2010). A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the GRACE genetics study. EUROPEAN HEART JOURNAL, 31(9), 1132–1141.
Vancouver
1.
Buysschaert I, Carruthers KF, Dunbar DR, Peuteman G, Rietzschel E, Belmans A, et al. A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the GRACE genetics study. EUROPEAN HEART JOURNAL. 2010;31(9):1132–41.
MLA
Buysschaert, Ian et al. “A Variant at Chromosome 9p21 Is Associated with Recurrent Myocardial Infarction and Cardiac Death After Acute Coronary Syndrome: The GRACE Genetics Study.” EUROPEAN HEART JOURNAL 31.9 (2010): 1132–1141. Print.
@article{909506,
  abstract     = {Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI). Here, we evaluated whether this variant also contributes to recurrent MI or cardiac death following an acute coronary syndrome (ACS).
A total of 3247 patients with ACS enrolled in the Global Registry of Acute Coronary Events (GRACE) in three distinct populations (UK, Belgium and Poland) were prospectively followed for 6 months and genotyped for rs1333049, in addition to 3004 and 2467 healthy controls from the UK and Belgium. After having confirmed that the at-risk C allele of rs1333049 was associated with index ACS in the UK and Belgian populations, we found that the rs1333049 at-risk C allele was significantly and independently associated with recurrent MI [age- and gender-adjusted hazard ratio (HR) 1.48, CI = 1.00-2.19, P = 0.048; and multivariable-adjusted HR 1.47, CI = 0.99-2.18; P = 0.053] and with recurrent MI or cardiac death (age- and gender-adjusted HR 1.58, CI = 1.00-2.48; P = 0.045; and multivariable adjusted HR 1.49, CI = 1.03-1.98; P = 0.028) within 6 months after an index ACS. Inclusion of rs1333049 into the GRACE risk score significantly improved classification for recurrent MI or cardiac death (P = 0.040), as calculated by the integrated discrimination improvement method.
In this large observational study, the 9p21 variant was independently associated with adverse cardiac outcome after ACS.},
  author       = {Buysschaert, Ian  and Carruthers, Kathryn F and Dunbar, Donald R and Peuteman, Gilian and Rietzschel, Ernst and Belmans, Ann and Hedley, Ann and De Meyer, Tim and Budaj, Andrzej and Van de Werf, Frans and Lambrechts, Diether and Fox, Keith AA},
  issn         = {0195-668X},
  journal      = {EUROPEAN HEART JOURNAL},
  keywords     = {Rs1333049,Chromosome 9p21,Genetics,ARTERY-DISEASE,METAANALYSIS,RISK,SUSCEPTIBILITY,PREDICTORS,RATIONALE,EVENTS,DESIGN,LOCUS,Myocardial infarction,Plaque rupture,Acute coronary syndrome},
  language     = {eng},
  number       = {9},
  pages        = {1132--1141},
  title        = {A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the GRACE genetics study},
  url          = {http://dx.doi.org/10.1093/eurheartj/ehq053},
  volume       = {31},
  year         = {2010},
}

Altmetric
View in Altmetric
Web of Science
Times cited: