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Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene

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Abstract
L- ficolin ( also called ficolin- 2, P35 or hucolin) is a soluble pattern recognition molecule of suspected importance in anti- microbial immunity. It activates the lectin pathway of complement and acts as an opsonin. L- ficolin, encoded by the FCN2 gene, recognizes microbial polysaccharides and glycoconjugates rich in GlcNAc or GalNAc. We report here data concerning four single nucleotide polymorphisms ( SNPs) of the FCN2 gene and their relationship to L- ficolin serum concentrations. There are two pairs of SNPs in linkage disequilibrium:ss32469536 ( located in promoter) with rs7851696 ( in exon 8) and ss32469537 ( promoter) with ss32469544 ( exon 8). We selected groups possessing low or high serum L- ficolin concentrations ( <= 2 mu 8 mg/ ml or > 4.5 mu g/ ml, respectively) from Polish children suffering from recurrent respiratory infections ( n = 146). Low L- ficolin levels were associated with variant alleles for ss32469536 and rs7851696 and normal alleles for ss32469537 and ss32469544. Conversely, high L- ficolin levels were associated with variant alleles of ss32469537 and ss32469544. FCN2 genotyping should be a valuable additional tool for disease association studies.
Keywords
MOLECULE, BLOOD, MANNAN-BINDING LECTIN, LECTIN COMPLEMENT PATHWAY, ACETYL GROUPS, ACTIVATION, PATTERN

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Chicago
Cedzynski, M, Lieve Nuytinck, APM Atkinson, A St Swierzko, K Zeman, J Szemraj, A Szala, ML Turner, and DC Kilpatrick. 2007. “Extremes of L-ficolin Concentration in Children with Recurrent Infections Are Associated with Single Nucleotide Polymorphisms in the FCN2 Gene.” Clinical and Experimental Immunology 150 (1): 99–104.
APA
Cedzynski, M., Nuytinck, L., Atkinson, A., St Swierzko, A., Zeman, K., Szemraj, J., Szala, A., et al. (2007). Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 150(1), 99–104.
Vancouver
1.
Cedzynski M, Nuytinck L, Atkinson A, St Swierzko A, Zeman K, Szemraj J, et al. Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. OXFORD: BLACKWELL PUBLISHING; 2007;150(1):99–104.
MLA
Cedzynski, M et al. “Extremes of L-ficolin Concentration in Children with Recurrent Infections Are Associated with Single Nucleotide Polymorphisms in the FCN2 Gene.” CLINICAL AND EXPERIMENTAL IMMUNOLOGY 150.1 (2007): 99–104. Print.
@article{906972,
  abstract     = {L- ficolin ( also called ficolin- 2, P35 or hucolin) is a soluble pattern recognition molecule of suspected importance in anti- microbial immunity. It activates the lectin pathway of complement and acts as an opsonin. L- ficolin, encoded by the FCN2 gene, recognizes microbial polysaccharides and glycoconjugates rich in GlcNAc or GalNAc. We report here data concerning four single nucleotide polymorphisms ( SNPs) of the FCN2 gene and their relationship to L- ficolin serum concentrations. There are two pairs of SNPs in linkage disequilibrium:ss32469536 ( located in promoter) with rs7851696 ( in exon 8) and ss32469537 ( promoter) with ss32469544 ( exon 8). We selected groups possessing low or high serum L- ficolin concentrations ( <= 2 mu 8 mg/ ml or > 4.5 mu g/ ml, respectively) from Polish children suffering from recurrent respiratory infections ( n = 146). Low L- ficolin levels were associated with variant alleles for ss32469536 and rs7851696 and normal alleles for ss32469537 and ss32469544. Conversely, high L- ficolin levels were associated with variant alleles of ss32469537 and ss32469544. FCN2 genotyping should be a valuable additional tool for disease association studies.},
  author       = {Cedzynski, M and Nuytinck, Lieve and Atkinson, APM and St Swierzko, A and Zeman, K and Szemraj, J and Szala, A and Turner, ML and Kilpatrick, DC},
  issn         = {0009-9104},
  journal      = {CLINICAL AND EXPERIMENTAL IMMUNOLOGY},
  keywords     = {MOLECULE,BLOOD,MANNAN-BINDING LECTIN,LECTIN COMPLEMENT PATHWAY,ACETYL GROUPS,ACTIVATION,PATTERN},
  language     = {eng},
  number       = {1},
  pages        = {99--104},
  publisher    = {BLACKWELL PUBLISHING},
  title        = {Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene},
  url          = {http://dx.doi.org/10.1111/j.1365-2249.2007.03471.x},
  volume       = {150},
  year         = {2007},
}

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