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Molecular and clinico-pathological markers in rectal cancer: a tissue micro-array study

Annelies Debucquoy, Laurence Goethals, Louis Libbrecht UGent, Christiaan Perneel, Karel Geboes, Nadine Ectors, William McBride and Karin Haustermans (2009) INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. 24(2). p.129-138
abstract
The aims of the study were to study the effect of pre-operative treatment on the expression of tumour-related proteins and to correlate the expression of these proteins with response and survival of patients with advanced rectal cancer. Tissue micro-arrays from pre- and post-treatment biopsies of 99 patients with rectal cancer treated with pre-operative (chemo)radiotherapy were stained for epidermal growth factor receptor (EGFR), carbonic anhydrase IX, Ki67, vascular endothelial growth factor, cyclo-oxygenase 2 (COX-2) and cleaved cytokeratin 18 (c-CK18). Also, fibro-inflammatory alterations after treatment were evaluated. Pre-operative (chemo)radiotherapy caused fibro-inflammatory changes, a downregulation of proliferation (Ki67) and EGFR and an upregulation of apoptosis (cleaved CK18). Patients with a good regression during pre-operative treatment showed less proliferating and apoptotic cells in the resection specimen. Multivariate analysis showed that T downstaging, fibro-inflammatory changes in the resection specimen and COX-2 expression in the biopsy correlated with overall survival. Pre-operative treatment has an effect on proliferation, apoptosis, inflammation and EGFR expression. The classical clinical parameters as well as fibro-inflammatory changes and COX-2 expression seem most valuable as predictors for survival.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
keyword
TOTAL MESORECTAL EXCISION, EPIDERMAL-GROWTH-FACTOR, CIRCUMFERENTIAL MARGIN INVOLVEMENT, COLORECTAL-CANCER, CELL-PROLIFERATION, CYCLOOXYGENASE-2 EXPRESSION, RADIATION-THERAPY, PREOPERATIVE RADIOCHEMOTHERAPY, ADJUVANT THERAPY, FACTOR RECEPTOR
journal title
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
Int. J. Colorectal Dis.
volume
24
issue
2
pages
10 pages
publisher
Springer
place of publication
NEW YORK
Web of Science type
Article
Web of Science id
000262412400001
JCR category
SURGERY
JCR impact factor
2.102 (2009)
JCR rank
47/166 (2009)
JCR quartile
2 (2009)
ISSN
0179-1958
DOI
10.1007/s00384-008-0608-8
language
English
UGent publication?
no
classification
A1
id
903920
handle
http://hdl.handle.net/1854/LU-903920
date created
2010-03-15 11:25:28
date last changed
2010-03-26 11:08:35
@article{903920,
  abstract     = {The aims of the study were to study the effect of pre-operative treatment on the expression of tumour-related proteins and to correlate the expression of these proteins with response and survival of patients with advanced rectal cancer.

Tissue micro-arrays from pre- and post-treatment biopsies of 99 patients with rectal cancer treated with pre-operative (chemo)radiotherapy were stained for epidermal growth factor receptor (EGFR), carbonic anhydrase IX, Ki67, vascular endothelial growth factor, cyclo-oxygenase 2 (COX-2) and cleaved cytokeratin 18 (c-CK18). Also, fibro-inflammatory alterations after treatment were evaluated.

Pre-operative (chemo)radiotherapy caused fibro-inflammatory changes, a downregulation of proliferation (Ki67) and EGFR and an upregulation of apoptosis (cleaved CK18). Patients with a good regression during pre-operative treatment showed less proliferating and apoptotic cells in the resection specimen. Multivariate analysis showed that T downstaging, fibro-inflammatory changes in the resection specimen and COX-2 expression in the biopsy correlated with overall survival.

Pre-operative treatment has an effect on proliferation, apoptosis, inflammation and EGFR expression. The classical clinical parameters as well as fibro-inflammatory changes and COX-2 expression seem most valuable as predictors for survival.},
  author       = {Debucquoy, Annelies and Goethals, Laurence and Libbrecht, Louis and Perneel, Christiaan and Geboes, Karel and Ectors, Nadine and McBride, William and Haustermans, Karin},
  issn         = {0179-1958},
  journal      = {INTERNATIONAL JOURNAL OF COLORECTAL DISEASE},
  keyword      = {TOTAL MESORECTAL EXCISION,EPIDERMAL-GROWTH-FACTOR,CIRCUMFERENTIAL MARGIN INVOLVEMENT,COLORECTAL-CANCER,CELL-PROLIFERATION,CYCLOOXYGENASE-2 EXPRESSION,RADIATION-THERAPY,PREOPERATIVE RADIOCHEMOTHERAPY,ADJUVANT THERAPY,FACTOR RECEPTOR},
  language     = {eng},
  number       = {2},
  pages        = {129--138},
  publisher    = {Springer},
  title        = {Molecular and clinico-pathological markers in rectal cancer: a tissue micro-array study},
  url          = {http://dx.doi.org/10.1007/s00384-008-0608-8},
  volume       = {24},
  year         = {2009},
}

Chicago
Debucquoy, Annelies, Laurence Goethals, Louis Libbrecht, Christiaan Perneel, Karel Geboes, Nadine Ectors, William McBride, and Karin Haustermans. 2009. “Molecular and Clinico-pathological Markers in Rectal Cancer: a Tissue Micro-array Study.” International Journal of Colorectal Disease 24 (2): 129–138.
APA
Debucquoy, Annelies, Goethals, L., Libbrecht, L., Perneel, C., Geboes, K., Ectors, N., McBride, W., et al. (2009). Molecular and clinico-pathological markers in rectal cancer: a tissue micro-array study. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 24(2), 129–138.
Vancouver
1.
Debucquoy A, Goethals L, Libbrecht L, Perneel C, Geboes K, Ectors N, et al. Molecular and clinico-pathological markers in rectal cancer: a tissue micro-array study. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. NEW YORK: Springer; 2009;24(2):129–38.
MLA
Debucquoy, Annelies, Laurence Goethals, Louis Libbrecht, et al. “Molecular and Clinico-pathological Markers in Rectal Cancer: a Tissue Micro-array Study.” INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 24.2 (2009): 129–138. Print.