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Inhibition of Candida albicans biofilm formation by antimycotics released from modified polydimethyl siloxane

Kristof De Prijck (UGent) , Nele De Smet (UGent) , Kris Honraet (UGent) , Steven Christiaen, Tom Coenye (UGent) , Etienne Schacht (UGent) and Hans Nelis (UGent)
(2010) MYCOPATHOLOGIA. 169(3). p.167-174
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Abstract
Unlike various disinfectants, antifungals have not been commonly incorporated so far in medical devices, such as catheters or prostheses, to prevent biofilm formation by Candida spp. In the present study, five antimycotics were added to polydimethyl siloxane (PDMS) disks via admixture (nystatin) or impregnation (trimethylsilyl-nystatin (TMS-nystatin), miconazole, tea tree oil (TTO), zinc pyrithione). Nystatin-medicated PDMS disks exhibited a concentration-dependent inhibitory effect on biofilm formation in a microtiter plate (MTP) but not in a Modified Robbins Device (MRD). This observation, together with HPLC data and agar diffusion tests, indicates that a small fraction of free nystatin is released, which kills Candida albicans cells in the limited volume of a MTP well. In contrast, biofilm inhibition amounted to more than one log unit in the MRD on disks impregnated with miconazole, TTO, and zinc pyrithione. It is hypothesized that the reduction in biofilm formation by these compounds in a flow system occurs through a contact-dependent effect.
Keywords
ANTIBIOTICS, PREVENTION, MODIFIED ROBBINS DEVICE, VOICE PROSTHESES, TISSUE DISTRIBUTION, MEDICAL DEVICES, LIPOSOMAL NYSTATIN, EFFICACY, INFECTION, SILVER

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Chicago
De Prijck, Kristof, Nele De Smet, Kris Honraet, Steven Christiaen, Tom Coenye, Etienne Schacht, and Hans Nelis. 2010. “Inhibition of Candida Albicans Biofilm Formation by Antimycotics Released from Modified Polydimethyl Siloxane.” Mycopathologia 169 (3): 167–174.
APA
De Prijck, K., De Smet, N., Honraet, K., Christiaen, S., Coenye, T., Schacht, E., & Nelis, H. (2010). Inhibition of Candida albicans biofilm formation by antimycotics released from modified polydimethyl siloxane. MYCOPATHOLOGIA, 169(3), 167–174.
Vancouver
1.
De Prijck K, De Smet N, Honraet K, Christiaen S, Coenye T, Schacht E, et al. Inhibition of Candida albicans biofilm formation by antimycotics released from modified polydimethyl siloxane. MYCOPATHOLOGIA. 2010;169(3):167–74.
MLA
De Prijck, Kristof et al. “Inhibition of Candida Albicans Biofilm Formation by Antimycotics Released from Modified Polydimethyl Siloxane.” MYCOPATHOLOGIA 169.3 (2010): 167–174. Print.
@article{899549,
  abstract     = {Unlike various disinfectants, antifungals have not been commonly incorporated so far in medical devices, such as catheters or prostheses, to prevent biofilm formation by Candida spp. In the present study, five antimycotics were added to polydimethyl siloxane (PDMS) disks via admixture (nystatin) or impregnation (trimethylsilyl-nystatin (TMS-nystatin), miconazole, tea tree oil (TTO), zinc pyrithione). Nystatin-medicated PDMS disks exhibited a concentration-dependent inhibitory effect on biofilm formation in a microtiter plate (MTP) but not in a Modified Robbins Device (MRD). This observation, together with HPLC data and agar diffusion tests, indicates that a small fraction of free nystatin is released, which kills Candida albicans cells in the limited volume of a MTP well. In contrast, biofilm inhibition amounted to more than one log unit in the MRD on disks impregnated with miconazole, TTO, and zinc pyrithione. It is hypothesized that the reduction in biofilm formation by these compounds in a flow system occurs through a contact-dependent effect.},
  author       = {De Prijck, Kristof and De Smet, Nele and Honraet, Kris and Christiaen, Steven and Coenye, Tom and Schacht, Etienne and Nelis, Hans},
  issn         = {0301-486X},
  journal      = {MYCOPATHOLOGIA},
  keywords     = {ANTIBIOTICS,PREVENTION,MODIFIED ROBBINS DEVICE,VOICE PROSTHESES,TISSUE DISTRIBUTION,MEDICAL DEVICES,LIPOSOMAL NYSTATIN,EFFICACY,INFECTION,SILVER},
  language     = {eng},
  number       = {3},
  pages        = {167--174},
  title        = {Inhibition of Candida albicans biofilm formation by antimycotics released from modified polydimethyl siloxane},
  url          = {http://dx.doi.org/10.1007/s11046-009-9242-4},
  volume       = {169},
  year         = {2010},
}

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