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A new danger in the air: how pulmonary innate immunity copes with man-made airborne xenobiotics

Ellen Lanckacker (UGent) , Lander Robays (UGent) , Guy Joos (UGent) and Karim Vermaelen (UGent)
(2010) Journal of Innate Immunity. 2(2). p.96-106
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Organization
Abstract
Abstract: The pulmonary innate immune system has evolved over millions of years to provide swift detection of inhaled microbial agents and trigger well-balanced protective responses. Much more recent on the evolutionary scale is human activity, which has resulted in the release of a new class of potentially harmful, non-microbial compounds into the air. These xenobiotics include combustion by-products such as reactive oxygen species and polycyclic aromatic hydrocarbons. This review will summarize evidence showing how airborne xenobiotics can engage pulmonary innate immunity components at many levels. We will focus on potential effects of xenobiotics on airway dendritic cells, as these constitute key innate immune sensors in the lung, with the unique ability to initiate adaptive immunity. We propose that the aberrant processing of inhaled xenobiotics by an innate immune system that is now evolutionarily maladapted underlies the increase in chronic inflammatory lung diseases in modern times.
Keywords
Aryl hydrocarbon receptor, dendritic cells, diesel, inflammation, innate immunity, NF kappa B signaling, oxidative stress, lung

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Citation

Please use this url to cite or link to this publication:

MLA
Lanckacker, Ellen et al. “A New Danger in the Air: How Pulmonary Innate Immunity Copes with Man-made Airborne Xenobiotics.” Journal of Innate Immunity 2.2 (2010): 96–106. Print.
APA
Lanckacker, E., Robays, L., Joos, G., & Vermaelen, K. (2010). A new danger in the air: how pulmonary innate immunity copes with man-made airborne xenobiotics. Journal of Innate Immunity, 2(2), 96–106.
Chicago author-date
Lanckacker, Ellen, Lander Robays, Guy Joos, and Karim Vermaelen. 2010. “A New Danger in the Air: How Pulmonary Innate Immunity Copes with Man-made Airborne Xenobiotics.” Journal of Innate Immunity 2 (2): 96–106.
Chicago author-date (all authors)
Lanckacker, Ellen, Lander Robays, Guy Joos, and Karim Vermaelen. 2010. “A New Danger in the Air: How Pulmonary Innate Immunity Copes with Man-made Airborne Xenobiotics.” Journal of Innate Immunity 2 (2): 96–106.
Vancouver
1.
Lanckacker E, Robays L, Joos G, Vermaelen K. A new danger in the air: how pulmonary innate immunity copes with man-made airborne xenobiotics. Journal of Innate Immunity. Basel, Switzerland: Karger; 2010;2(2):96–106.
IEEE
[1]
E. Lanckacker, L. Robays, G. Joos, and K. Vermaelen, “A new danger in the air: how pulmonary innate immunity copes with man-made airborne xenobiotics,” Journal of Innate Immunity, vol. 2, no. 2, pp. 96–106, 2010.
@article{899240,
  abstract     = {Abstract: The pulmonary innate immune system has evolved over millions of years to provide swift detection of inhaled microbial agents and trigger well-balanced protective responses. Much more recent on the evolutionary scale is human activity, which has resulted in the release of a new class of potentially harmful, non-microbial compounds into the air. These xenobiotics include combustion by-products such as reactive oxygen species and polycyclic aromatic hydrocarbons. This review will summarize evidence showing how airborne xenobiotics can engage pulmonary innate immunity components at many levels. We will focus on potential effects of xenobiotics on airway dendritic cells, as these constitute key innate immune sensors in the lung, with the unique ability to initiate adaptive immunity. We propose that the aberrant processing of inhaled xenobiotics by an innate immune system that is now evolutionarily maladapted underlies the increase in chronic inflammatory lung diseases in modern times.},
  author       = {Lanckacker, Ellen and Robays, Lander and Joos, Guy and Vermaelen, Karim},
  issn         = {1662-811X},
  journal      = {Journal of Innate Immunity},
  keywords     = {Aryl hydrocarbon receptor,dendritic cells,diesel,inflammation,innate immunity,NF kappa B signaling,oxidative stress,lung},
  language     = {eng},
  number       = {2},
  pages        = {96--106},
  publisher    = {Karger},
  title        = {A new danger in the air: how pulmonary innate immunity copes with man-made airborne xenobiotics},
  url          = {http://dx.doi.org/10.1159/000243784},
  volume       = {2},
  year         = {2010},
}

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