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Effects of pulmonary rehabilitation in patients with restrictive lung diseases

Bihiyga Salhi UGent, Thierry Troosters, Mia Behaegel, Guy Joos UGent and Eric Derom UGent (2010) Chest. 137(2). p.273-279
abstract
Abstract: Background: Pulmonary rehabilitation programs improve exercise tolerance, muscle strength, and dyspnea in patients with COPD. The aim of the study was to assess prospectively the effectiveness and feasibility of pulmonary rehabilitation in patients with restrictive lung diseases. Methods: In a prospective, nonrandomized, noncontrolled study, patients with an established diagnosis of restrictive lung disease (RLD) participated in a 24-week outpatient multidisciplinary rehabilitation program. Pulmonary function, exercise capacity, muscle force, and dyspnea were measured at inclusion, after 12 and 24 weeks of rehabilitation. Primary outcome was the change in 6-min walk distance (6MWD) after 12 weeks of rehabilitation. Results: Twenty-nine patients out of 31 patients (57 +/- 17 years of age; 21 men; FEV1: 1.4 +/- 0.7 L) completed the 12-week rehabilitation program and 26 patients the 24-week rehabilitation program. At inclusion, exercise tolerance (maximal oxygen consumption [Vo(2)max]: 63% +/- 27% predicted; 6MWD: 390 +/- 140 m) and quadriceps force ([QF] 61% +/- 21% predicted) were reduced, and dyspnea, assessed using the Chronic Respiratory Disease Questionnaire (CRDQ), was increased (CRDQ item dyspnea [CRDQd]: 16 +/- 6 points). Exercise capacity, muscle force, and CRDQd improved significantly after 12 weeks (6MWD: 445 +/- 142M; Vo(2)max: 69% +/- 30% predicted; QF: 73% +/- 25% predicted; CRDQd: 20 +/- 6 points) (P<.05). Further improvements were noted after 24 weeks (6MWD; 463 +/- 146 m; CRDQd: 22 +/- 6 points). Conclusions: Patients with RLD respond well after 12 weeks of pulmonary rehabilitation, and even better results were seen after 24 weeks. Clinically significant improvements were obtained in the majority of the patients after 24 weeks.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
weakness, trial, exercise capacity, Quality of life, fibrosis, statement
journal title
Chest
Chest
volume
137
issue
2
pages
273 - 279
publisher
Amer Coll Chest Physicians
place of publication
Northbrook Il, USA
Web of Science type
Article
Web of Science id
000274612600007
JCR category
RESPIRATORY SYSTEM
JCR impact factor
6.519 (2010)
JCR rank
3/45 (2010)
JCR quartile
1 (2010)
ISSN
0012-3692
DOI
10.1378/chest.09-0241
language
English
UGent publication?
yes
classification
A1
id
898908
handle
http://hdl.handle.net/1854/LU-898908
date created
2010-03-09 11:53:37
date last changed
2010-03-26 08:47:36
@article{898908,
  abstract     = {Abstract: Background: Pulmonary rehabilitation programs improve exercise tolerance, muscle strength, and dyspnea in patients with COPD. The aim of the study was to assess prospectively the effectiveness and feasibility of pulmonary rehabilitation in patients with restrictive lung diseases.
Methods: In a prospective, nonrandomized, noncontrolled study, patients with an established diagnosis of restrictive lung disease (RLD) participated in a 24-week outpatient multidisciplinary rehabilitation program. Pulmonary function, exercise capacity, muscle force, and dyspnea were measured at inclusion, after 12 and 24 weeks of rehabilitation. Primary outcome was the change in 6-min walk distance (6MWD) after 12 weeks of rehabilitation.

Results: Twenty-nine patients out of 31 patients (57 +/- 17 years of age; 21 men; FEV1: 1.4 +/- 0.7 L) completed the 12-week rehabilitation program and 26 patients the 24-week rehabilitation program. At inclusion, exercise tolerance (maximal oxygen consumption [Vo(2)max]: 63\% +/- 27\% predicted; 6MWD: 390 +/- 140 m) and quadriceps force ([QF] 61\% +/- 21\% predicted) were reduced, and dyspnea, assessed using the Chronic Respiratory Disease Questionnaire (CRDQ), was increased (CRDQ item dyspnea [CRDQd]: 16 +/- 6 points). Exercise capacity, muscle force, and CRDQd improved significantly after 12 weeks (6MWD: 445 +/- 142M; Vo(2)max: 69\% +/- 30\% predicted; QF: 73\% +/- 25\% predicted; CRDQd: 20 +/- 6 points) (P{\textlangle}.05). Further improvements were noted after 24 weeks (6MWD; 463 +/- 146 m; CRDQd: 22 +/- 6 points).

Conclusions: Patients with RLD respond well after 12 weeks of pulmonary rehabilitation, and even better results were seen after 24 weeks. Clinically significant improvements were obtained in the majority of the patients after 24 weeks.},
  author       = {Salhi, Bihiyga and Troosters, Thierry and Behaegel, Mia and Joos, Guy and Derom, Eric},
  issn         = {0012-3692},
  journal      = {Chest},
  keyword      = {weakness,trial,exercise capacity,Quality of life,fibrosis,statement},
  language     = {eng},
  number       = {2},
  pages        = {273--279},
  publisher    = {Amer Coll Chest Physicians},
  title        = {Effects of pulmonary rehabilitation in patients with restrictive lung diseases},
  url          = {http://dx.doi.org/10.1378/chest.09-0241},
  volume       = {137},
  year         = {2010},
}

Chicago
Salhi, Bihiyga, Thierry Troosters, Mia Behaegel, Guy Joos, and Eric Derom. 2010. “Effects of Pulmonary Rehabilitation in Patients with Restrictive Lung Diseases.” Chest 137 (2): 273–279.
APA
Salhi, B., Troosters, T., Behaegel, M., Joos, G., & Derom, E. (2010). Effects of pulmonary rehabilitation in patients with restrictive lung diseases. Chest, 137(2), 273–279.
Vancouver
1.
Salhi B, Troosters T, Behaegel M, Joos G, Derom E. Effects of pulmonary rehabilitation in patients with restrictive lung diseases. Chest. Northbrook Il, USA: Amer Coll Chest Physicians; 2010;137(2):273–9.
MLA
Salhi, Bihiyga, Thierry Troosters, Mia Behaegel, et al. “Effects of Pulmonary Rehabilitation in Patients with Restrictive Lung Diseases.” Chest 137.2 (2010): 273–279. Print.