Ghent University Academic Bibliography

Advanced

Muscle carnosine metabolism and β-alanine supplementation in relation to exercise and training

Wim Derave UGent, Inge Everaert UGent, Sam Beeckman UGent and Audrey Baguet UGent (2010) SPORTS MEDICINE. 40(3). p.247-263
abstract
Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and beta-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase. Recent studies have shown that the chronic oral ingestion of beta-alanine can substantially elevate (up to 80%) the carnosine content of human skeletal muscle. Interestingly, muscle carnosine loading leads to improved performance in high-intensity exercise in both untrained and trained individuals. Although carnosine is not involved in the classic adenosine triphosphate-generating metabolic pathways, this suggests an important role of the dipeptide in the homeostasis of contracting muscle cells, especially during high rates of anaerobic energy delivery. Carnosine may attenuate acidosis by acting as a pH buffer, but improved contractile performance may also be obtained by improved excitation-contraction coupling and defence against reactive oxygen species. High carnosine concentrations are found in individuals with a high proportion of fast-twitch fibres, because these fibres are enriched with the dipeptide. Muscle carnosine content is lower in women, declines with age and is probably lower in vegetarians, whose diets are deprived of beta-alanine. Sprint-trained athletes display markedly high muscular carnosine, but the acute effect of several weeks of training on muscle carnosine is limited. High carnosine levels in elite sprinters are therefore either an important genetically determined talent selection criterion or a result of slow adaptation to years of training. beta-Alanine is rapidly developing as a popular ergogenic nutritional supplement for athletes worldwide, and the currently available scientific literature suggests that its use is evidence based. However, many aspects of the supplement, such as the potential side effects and the mechanism of action, require additional and thorough investigation by the sports science community.
Please use this url to cite or link to this publication:
author
organization
alternative title
Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training
year
type
journalArticle (review)
publication status
published
subject
keyword
ENDURANCE PERFORMANCE, NEUROMUSCULAR FATIGUE, TAURINE CONTENTS, BUFFERING CAPACITY, CREATINE SUPPLEMENTATION, SARCOPLASMIC-RETICULUM, CA-RELEASE CHANNELS, MIDDLE GLUTEAL MUSCLE, HUMAN SKELETAL-MUSCLE, HUMAN VASTUS LATERALIS
journal title
SPORTS MEDICINE
Sports Med.
volume
40
issue
3
pages
247 - 263
Web of Science type
Review
Web of Science id
000276294400005
JCR category
SPORT SCIENCES
JCR impact factor
5.072 (2010)
JCR rank
1/79 (2010)
JCR quartile
1 (2010)
ISSN
0112-1642
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
897781
handle
http://hdl.handle.net/1854/LU-897781
date created
2010-03-05 15:36:26
date last changed
2012-01-01 00:30:22
@article{897781,
  abstract     = {Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and beta-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase. Recent studies have shown that the chronic oral ingestion of beta-alanine can substantially elevate (up to 80\%) the carnosine content of human skeletal muscle. Interestingly, muscle carnosine loading leads to improved performance in high-intensity exercise in both untrained and trained individuals. Although carnosine is not involved in the classic adenosine triphosphate-generating metabolic pathways, this suggests an important role of the dipeptide in the homeostasis of contracting muscle cells, especially during high rates of anaerobic energy delivery. Carnosine may attenuate acidosis by acting as a pH buffer, but improved contractile performance may also be obtained by improved excitation-contraction coupling and defence against reactive oxygen species. High carnosine concentrations are found in individuals with a high proportion of fast-twitch fibres, because these fibres are enriched with the dipeptide. Muscle carnosine content is lower in women, declines with age and is probably lower in vegetarians, whose diets are deprived of beta-alanine. Sprint-trained athletes display markedly high muscular carnosine, but the acute effect of several weeks of training on muscle carnosine is limited. High carnosine levels in elite sprinters are therefore either an important genetically determined talent selection criterion or a result of slow adaptation to years of training. beta-Alanine is rapidly developing as a popular ergogenic nutritional supplement for athletes worldwide, and the currently available scientific literature suggests that its use is evidence based. However, many aspects of the supplement, such as the potential side effects and the mechanism of action, require additional and thorough investigation by the sports science community.},
  author       = {Derave, Wim and Everaert, Inge and Beeckman, Sam and Baguet, Audrey},
  issn         = {0112-1642},
  journal      = {SPORTS MEDICINE},
  keyword      = {ENDURANCE PERFORMANCE,NEUROMUSCULAR FATIGUE,TAURINE CONTENTS,BUFFERING CAPACITY,CREATINE SUPPLEMENTATION,SARCOPLASMIC-RETICULUM,CA-RELEASE CHANNELS,MIDDLE GLUTEAL MUSCLE,HUMAN SKELETAL-MUSCLE,HUMAN VASTUS LATERALIS},
  language     = {eng},
  number       = {3},
  pages        = {247--263},
  title        = {Muscle carnosine metabolism and \ensuremath{\beta}-alanine supplementation in relation to exercise and training},
  volume       = {40},
  year         = {2010},
}

Chicago
Derave, Wim, Inge Everaert, Sam Beeckman, and Audrey Baguet. 2010. “Muscle Carnosine Metabolism and Β-alanine Supplementation in Relation to Exercise and Training.” Sports Medicine 40 (3): 247–263.
APA
Derave, W., Everaert, I., Beeckman, S., & Baguet, A. (2010). Muscle carnosine metabolism and β-alanine supplementation in relation to exercise and training. SPORTS MEDICINE, 40(3), 247–263.
Vancouver
1.
Derave W, Everaert I, Beeckman S, Baguet A. Muscle carnosine metabolism and β-alanine supplementation in relation to exercise and training. SPORTS MEDICINE. 2010;40(3):247–63.
MLA
Derave, Wim, Inge Everaert, Sam Beeckman, et al. “Muscle Carnosine Metabolism and Β-alanine Supplementation in Relation to Exercise and Training.” SPORTS MEDICINE 40.3 (2010): 247–263. Print.