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Thermoresponsive poly(N-vinylcaprolactam) as stationary phase for aqueous and green liquid chromatography

Bram Miserez UGent, Frederic Lynen UGent, Adrian Wright, Melvin Euerby and Patrick Sandra UGent (2010) CHROMATOGRAPHIA. 71(1-2). p.1-6
abstract
Poly(N-vinylcaprolactam) (PVCL) connected to aminopropyl silica is a new stationary phase for temperature responsive liquid chromatography (TR-LC). PVCL shows a transition from hydrophilic to hydrophobic interaction between 30 and 40 degrees C. The synthesis is described in detail. The temperature responsive characteristic of the phase is illustrated with a mixture of steroids using pure water as mobile phase. An increase in retention is observed when raising the temperature. H-u plots at different temperatures were constructed. Below the lower critical solution temperature (LCST), no optimal velocity could be measured because of substantial resistance to mass transfer. Above the LCST, u (opt) was ca. 0.3 mm s(-1) with reduced plate heights from 4 at 45 degrees C to 3 at 65 degrees C. The temperature responsive nature of the polymer is lost in green chromatography with ethanol as modifier in concentrations above 5%.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
N-ISOPROPYLACRYLAMIDE, POLYMER, MODIFIED SILICA, TEMPERATURE-RESPONSIVE CHROMATOGRAPHY, Poly(N-vinylcaprolactam), Aqueous and green mobile phases, Column liquid chromatography, Thermoresponsive liquid chromatography, SYSTEM, PH, VINYLCAPROLACTAM, COPOLYMERS, ONLINE, CELLS
journal title
CHROMATOGRAPHIA
Chromatographia
volume
71
issue
1-2
pages
1 - 6
Web of Science type
Article
Web of Science id
000273352500001
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
1.075 (2010)
JCR rank
51/71 (2010)
JCR quartile
3 (2010)
ISSN
0009-5893
DOI
10.1365/s10337-009-1394-3
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
888915
handle
http://hdl.handle.net/1854/LU-888915
date created
2010-03-03 15:02:46
date last changed
2010-11-22 16:44:19
@article{888915,
  abstract     = {Poly(N-vinylcaprolactam) (PVCL) connected to aminopropyl silica is a new stationary phase for temperature responsive liquid chromatography (TR-LC). PVCL shows a transition from hydrophilic to hydrophobic interaction between 30 and 40  degrees C. The synthesis is described in detail. The temperature responsive characteristic of the phase is illustrated with a mixture of steroids using pure water as mobile phase. An increase in retention is observed when raising the temperature. H-u plots at different temperatures were constructed. Below the lower critical solution temperature (LCST), no optimal velocity could be measured because of substantial resistance to mass transfer. Above the LCST, u (opt) was ca. 0.3 mm s(-1) with reduced plate heights from 4 at 45  degrees C to 3 at 65  degrees C. The temperature responsive nature of the polymer is lost in green chromatography with ethanol as modifier in concentrations above 5\%.},
  author       = {Miserez, Bram and Lynen, Frederic and Wright, Adrian and Euerby, Melvin and Sandra, Patrick},
  issn         = {0009-5893},
  journal      = {CHROMATOGRAPHIA},
  keyword      = {N-ISOPROPYLACRYLAMIDE,POLYMER,MODIFIED SILICA,TEMPERATURE-RESPONSIVE CHROMATOGRAPHY,Poly(N-vinylcaprolactam),Aqueous and green mobile phases,Column liquid chromatography,Thermoresponsive liquid chromatography,SYSTEM,PH,VINYLCAPROLACTAM,COPOLYMERS,ONLINE,CELLS},
  language     = {eng},
  number       = {1-2},
  pages        = {1--6},
  title        = {Thermoresponsive poly(N-vinylcaprolactam) as stationary phase for aqueous and green liquid chromatography},
  url          = {http://dx.doi.org/10.1365/s10337-009-1394-3},
  volume       = {71},
  year         = {2010},
}

Chicago
Miserez, Bram, Frederic Lynen, Adrian Wright, Melvin Euerby, and Patrick Sandra. 2010. “Thermoresponsive poly(N-vinylcaprolactam) as Stationary Phase for Aqueous and Green Liquid Chromatography.” Chromatographia 71 (1-2): 1–6.
APA
Miserez, B., Lynen, F., Wright, A., Euerby, M., & Sandra, P. (2010). Thermoresponsive poly(N-vinylcaprolactam) as stationary phase for aqueous and green liquid chromatography. CHROMATOGRAPHIA, 71(1-2), 1–6.
Vancouver
1.
Miserez B, Lynen F, Wright A, Euerby M, Sandra P. Thermoresponsive poly(N-vinylcaprolactam) as stationary phase for aqueous and green liquid chromatography. CHROMATOGRAPHIA. 2010;71(1-2):1–6.
MLA
Miserez, Bram, Frederic Lynen, Adrian Wright, et al. “Thermoresponsive poly(N-vinylcaprolactam) as Stationary Phase for Aqueous and Green Liquid Chromatography.” CHROMATOGRAPHIA 71.1-2 (2010): 1–6. Print.