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Voriconazole, a safe alternative for treating infections caused by the Chrysosporium anamorph of Nannizziopsis vriesii in bearded dragons (Pogona vitticeps)

Lieven Van Waeyenberghe UGent, Kris Baert UGent, Frank Pasmans UGent, Pascale Van Rooij, Tom Hellebuyck UGent, Lies Beernaert UGent, Patrick De Backer UGent, Freddy Haesebrouck UGent and An Martel UGent (2010) MEDICAL MYCOLOGY. 48(6). p.880-885
abstract
Dermal and systemic infections caused by the Chrysosporium anamorph of Nannizziopsis vriesii (CANV) are highly prevalent in reptiles and may result in severe disease and high mortality. Due to the high incidence of therapeutic failures, optimizing treatment is required. We first determined in this study the minimal inhibitory concentrations (MIC) of itraconazole, voriconazole, amphotericin B and terbinafine against 32 CANV isolates. For voriconazole, amphotericin B and terbinafine a monomodal MIC distribution was seen, whereas a bimodal MIC distribution was present for itraconazole, indicating acquired resistance in one isolate. Fourteen naturally-infected bearded dragons (Pogona vitticeps), from the same owner, were treated orally with either itraconazole (5 mg/kg q24h) or voriconazole (10 mg/kg q24h). The clinical condition, drug plasma concentrations and the presence of CANV in skin samples were followed. The animals were treated until complete clearance of the fungus. The plasma concentrations of voriconazole and itraconazole exceeded the minimal inhibitory concentrations of the CANV isolates. Elimination of CANV was achieved on average after 27 and 47 days of treatment with itraconazole and voriconazole, respectively. Whereas only 2 out of 7 survived after itraconazole treatment, only a single animal died in the voriconazole treated group. In conclusion, based on a limited number of animals, voriconazole applied at a regimen of 10 mg/kg bodyweight (BW) q24h seems to be a safe and effective antimycotic drug to eliminate CANV infections in bearded dragons.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SERUM, Chrysosporium anamorph of Nannizziopsis vriesii, DERMATITIS, ITRACONAZOLE, PHARMACOKINETICS, CUTANEOUS MYCOSES, voriconazole, treatment, bearded dragon, dermatitis
journal title
MEDICAL MYCOLOGY
Med. Mycol.
volume
48
issue
6
pages
880 - 885
Web of Science type
Article
Web of Science id
000282200500016
JCR category
VETERINARY SCIENCES
JCR impact factor
2.329 (2010)
JCR rank
10/145 (2010)
JCR quartile
1 (2010)
ISSN
1369-3786
DOI
10.3109/13693781003743122
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
887738
handle
http://hdl.handle.net/1854/LU-887738
date created
2010-03-02 16:26:49
date last changed
2016-12-19 15:46:39
@article{887738,
  abstract     = {Dermal and systemic infections caused by the Chrysosporium anamorph of Nannizziopsis vriesii (CANV) are highly prevalent in reptiles and may result in severe disease and high mortality. Due to the high incidence of therapeutic failures, optimizing treatment is required. We first determined in this study the minimal inhibitory concentrations (MIC) of itraconazole, voriconazole, amphotericin B and terbinafine against 32 CANV isolates. For voriconazole, amphotericin B and terbinafine a monomodal MIC distribution was seen, whereas a bimodal MIC distribution was present for itraconazole, indicating acquired resistance in one isolate. Fourteen naturally-infected bearded dragons (Pogona vitticeps), from the same owner, were treated orally with either itraconazole (5 mg/kg q24h) or voriconazole (10 mg/kg q24h). The clinical condition, drug plasma concentrations and the presence of CANV in skin samples were followed. The animals were treated until complete clearance of the fungus. The plasma concentrations of voriconazole and itraconazole exceeded the minimal inhibitory concentrations of the CANV isolates. Elimination of CANV was achieved on average after 27 and 47 days of treatment with itraconazole and voriconazole, respectively. Whereas only 2 out of 7 survived after itraconazole treatment, only a single animal died in the voriconazole treated group. In conclusion, based on a limited number of animals, voriconazole applied at a regimen of 10 mg/kg bodyweight (BW) q24h seems to be a safe and effective antimycotic drug to eliminate CANV infections in bearded dragons.},
  author       = {Van Waeyenberghe, Lieven and Baert, Kris and Pasmans, Frank and Van Rooij, Pascale and Hellebuyck, Tom and Beernaert, Lies and De Backer, Patrick and Haesebrouck, Freddy and Martel, An},
  issn         = {1369-3786},
  journal      = {MEDICAL MYCOLOGY},
  keyword      = {SERUM,Chrysosporium anamorph of Nannizziopsis vriesii,DERMATITIS,ITRACONAZOLE,PHARMACOKINETICS,CUTANEOUS MYCOSES,voriconazole,treatment,bearded dragon,dermatitis},
  language     = {eng},
  number       = {6},
  pages        = {880--885},
  title        = {Voriconazole, a safe alternative for treating infections caused by the Chrysosporium anamorph of Nannizziopsis vriesii in bearded dragons (Pogona vitticeps)},
  url          = {http://dx.doi.org/10.3109/13693781003743122},
  volume       = {48},
  year         = {2010},
}

Chicago
Van Waeyenberghe, Lieven, Kris Baert, Frank Pasmans, Pascale Van Rooij, Tom Hellebuyck, Lies Beernaert, Patrick De Backer, Freddy Haesebrouck, and An Martel. 2010. “Voriconazole, a Safe Alternative for Treating Infections Caused by the Chrysosporium Anamorph of Nannizziopsis Vriesii in Bearded Dragons (Pogona Vitticeps).” Medical Mycology 48 (6): 880–885.
APA
Van Waeyenberghe, L., Baert, K., Pasmans, F., Van Rooij, P., Hellebuyck, T., Beernaert, L., De Backer, P., et al. (2010). Voriconazole, a safe alternative for treating infections caused by the Chrysosporium anamorph of Nannizziopsis vriesii in bearded dragons (Pogona vitticeps). MEDICAL MYCOLOGY, 48(6), 880–885.
Vancouver
1.
Van Waeyenberghe L, Baert K, Pasmans F, Van Rooij P, Hellebuyck T, Beernaert L, et al. Voriconazole, a safe alternative for treating infections caused by the Chrysosporium anamorph of Nannizziopsis vriesii in bearded dragons (Pogona vitticeps). MEDICAL MYCOLOGY. 2010;48(6):880–5.
MLA
Van Waeyenberghe, Lieven, Kris Baert, Frank Pasmans, et al. “Voriconazole, a Safe Alternative for Treating Infections Caused by the Chrysosporium Anamorph of Nannizziopsis Vriesii in Bearded Dragons (Pogona Vitticeps).” MEDICAL MYCOLOGY 48.6 (2010): 880–885. Print.