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Effect of various n-3/n-6 fatty acid ratio contents of high fat diets on rat liver and heart peroxisomal and mitochondrial β-oxidation

(1993) BIOCHIMICA ET BIOPHYSICA ACTA. 1170(2). p.151-156
Author
Organization
Abstract
The present work extends tissue investigations previously performed in rat gastric mucosa on lipid metabolism alterations caused by n - 3 and n - 6 fatty acid-enriched diets [13-15]. Liver and heart tissues are here studied and demonstrated to undergo, upon exposure to high fat diets with various n - 3/n - 6 fatty acid ratio contents, biochemical and morphological changes which may be enumerated as follows: (1) Rat liver peroxisomal prostaglandin E2, fatty acid but not bile acid beta-oxidation rates are enhanced, especially upon the diet with the higher n - 3/n - 6 fatty acid ratio. Mitochondrial beta-oxidation rates are little or not affected by the high fat diets. (2) Rat liver carnitine acyltransferases are stimulated by the high fat diets, the more rich the n - 3 fatty acid content, the more pronounced the stimulatory effect. (3) Rat heart peroxisomal and mitochondrial beta-oxidation rates were increased in animals receiving the n - 3 fatty acid-enriched diet. At a low n - 3/n - 6 fatty acid ratio content of the diet, these oxidizing rate values were in control range. The carnitine acyltransferase activities were increased in rat heart to different extents, depending on the n - 3/n - 6 fatty acid ratio content of the diet. (4) Ultrastructural examination and morphometric determinations on hepatocytes from rats receiving the diets with the lowest and the highest n - 3/n - 6 fatty acid ratio contents disclose that in the latter case the numbers and fractional volumes of peroxisomes and mitochondria are significantly higher than in the former case.
Keywords
FATTY ACID CONTENT, HIGH FAT DIET, PEROXISOME, MITOCHONDRION, BETA-OXIDATION, LIVER, HEART, (RAT), GASTRIC-MUCOSA, SALMON OIL, FISH OIL, CORN-OIL, LIPOPROTEIN METABOLISM, ENZYME-ACTIVITIES, N-3, LIPIDS, PROSTAGLANDIN-E2, PROLIFERATORS

Citation

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Chicago
Vamecq, J, L Vallée, PL Delaporte, M Fontaine, Dirk De Craemer, C Van Den Branden, H Lafont, R Grataroli, and G Nalbone. 1993. “Effect of Various N-3/n-6 Fatty Acid Ratio Contents of High Fat Diets on Rat Liver and Heart Peroxisomal and Mitochondrial Β-oxidation.” Biochimica Et Biophysica Acta 1170 (2): 151–156.
APA
Vamecq, J., Vallée, L., Delaporte, P., Fontaine, M., De Craemer, D., Van Den Branden, C., Lafont, H., et al. (1993). Effect of various n-3/n-6 fatty acid ratio contents of high fat diets on rat liver and heart peroxisomal and mitochondrial β-oxidation. BIOCHIMICA ET BIOPHYSICA ACTA, 1170(2), 151–156.
Vancouver
1.
Vamecq J, Vallée L, Delaporte P, Fontaine M, De Craemer D, Van Den Branden C, et al. Effect of various n-3/n-6 fatty acid ratio contents of high fat diets on rat liver and heart peroxisomal and mitochondrial β-oxidation. BIOCHIMICA ET BIOPHYSICA ACTA. 1993;1170(2):151–6.
MLA
Vamecq, J, L Vallée, PL Delaporte, et al. “Effect of Various N-3/n-6 Fatty Acid Ratio Contents of High Fat Diets on Rat Liver and Heart Peroxisomal and Mitochondrial Β-oxidation.” BIOCHIMICA ET BIOPHYSICA ACTA 1170.2 (1993): 151–156. Print.
@article{887258,
  abstract     = {The present work extends tissue investigations previously performed in rat gastric mucosa on lipid metabolism alterations caused by n - 3 and n - 6 fatty acid-enriched diets [13-15]. Liver and heart tissues are here studied and demonstrated to undergo, upon exposure to high fat diets with various n - 3/n - 6 fatty acid ratio contents, biochemical and morphological changes which may be enumerated as follows: (1) Rat liver peroxisomal prostaglandin E2, fatty acid but not bile acid beta-oxidation rates are enhanced, especially upon the diet with the higher n - 3/n - 6 fatty acid ratio. Mitochondrial beta-oxidation rates are little or not affected by the high fat diets. (2) Rat liver carnitine acyltransferases are stimulated by the high fat diets, the more rich the n - 3 fatty acid content, the more pronounced the stimulatory effect. (3) Rat heart peroxisomal and mitochondrial beta-oxidation rates were increased in animals receiving the n - 3 fatty acid-enriched diet. At a low n - 3/n - 6 fatty acid ratio content of the diet, these oxidizing rate values were in control range. The carnitine acyltransferase activities were increased in rat heart to different extents, depending on the n - 3/n - 6 fatty acid ratio content of the diet. (4) Ultrastructural examination and morphometric determinations on hepatocytes from rats receiving the diets with the lowest and the highest n - 3/n - 6 fatty acid ratio contents disclose that in the latter case the numbers and fractional volumes of peroxisomes and mitochondria are significantly higher than in the former case.},
  author       = {Vamecq, J and Vallée, L and Delaporte, PL and Fontaine, M and De Craemer, Dirk and Van Den Branden, C and Lafont, H and Grataroli, R and Nalbone, G},
  issn         = {0006-3002},
  journal      = {BIOCHIMICA ET BIOPHYSICA ACTA},
  keywords     = {FATTY ACID CONTENT,HIGH FAT DIET,PEROXISOME,MITOCHONDRION,BETA-OXIDATION,LIVER,HEART,(RAT),GASTRIC-MUCOSA,SALMON OIL,FISH OIL,CORN-OIL,LIPOPROTEIN METABOLISM,ENZYME-ACTIVITIES,N-3,LIPIDS,PROSTAGLANDIN-E2,PROLIFERATORS},
  language     = {eng},
  number       = {2},
  pages        = {151--156},
  title        = {Effect of various n-3/n-6 fatty acid ratio contents of high fat diets on rat liver and heart peroxisomal and mitochondrial β-oxidation},
  url          = {http://dx.doi.org/10.1016/0005-2760(93)90065-H},
  volume       = {1170},
  year         = {1993},
}

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