Enalapril increases antioxidant enzyme activity in renal cortical tissue of five-sixths-nephrectomized rats
- Author
- Dierik L Verbeelen, Dirk De Craemer (UGent) , Patrick Peeters, Katherina Vanden Houte and Christiane Van den Branden
- Organization
- Abstract
- In rats with five-sixths nephrectomy (remnant kidney), blood pressure, glomerulosclerosis, and proteinuria are significantly reduced by administration of the angiotensin-converting enzyme inhibitor enalapril, during 16 weeks after reduction of the nephron number. The activity of catalase in remnant-kidney cortex homogenate is not influenced by enalapril treatment; the activities of superoxide dismutase and glutathione peroxidase are significantly increased. Elevated lipid peroxidation in cortex homogenates, evaluated by malondialdehyde and 4-hydroxynonenal concentrations, is not changed by treatment. Supplementation of dietary vitamin E to enalapril treatment does not alter antioxidant enzyme activities when compared to enalapril monotherapy. These results show that enalapril improves the balance between reactive oxygen intermediates and antioxidant enzymes in the remnant-kidney cortex of the rat. This finding may in part explain the protective effect of angiotensin-converting enzyme inhibitors on the progression of glomerulosclerosis.
- Keywords
- enalapril, antioxidant enzymes, angiotensin-converting enzyme inhibitors, glomerulosclerosis, reactive oxygen intermediates, remnant kidney
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-887142
- MLA
- Verbeelen, Dierik L., et al. “Enalapril Increases Antioxidant Enzyme Activity in Renal Cortical Tissue of Five-Sixths-Nephrectomized Rats.” NEPHRON, vol. 80, no. 2, 1998, pp. 214–19, doi:10.1159/000045170.
- APA
- Verbeelen, D. L., De Craemer, D., Peeters, P., Vanden Houte, K., & Van den Branden, C. (1998). Enalapril increases antioxidant enzyme activity in renal cortical tissue of five-sixths-nephrectomized rats. NEPHRON, 80(2), 214–219. https://doi.org/10.1159/000045170
- Chicago author-date
- Verbeelen, Dierik L, Dirk De Craemer, Patrick Peeters, Katherina Vanden Houte, and Christiane Van den Branden. 1998. “Enalapril Increases Antioxidant Enzyme Activity in Renal Cortical Tissue of Five-Sixths-Nephrectomized Rats.” NEPHRON 80 (2): 214–19. https://doi.org/10.1159/000045170.
- Chicago author-date (all authors)
- Verbeelen, Dierik L, Dirk De Craemer, Patrick Peeters, Katherina Vanden Houte, and Christiane Van den Branden. 1998. “Enalapril Increases Antioxidant Enzyme Activity in Renal Cortical Tissue of Five-Sixths-Nephrectomized Rats.” NEPHRON 80 (2): 214–219. doi:10.1159/000045170.
- Vancouver
- 1.Verbeelen DL, De Craemer D, Peeters P, Vanden Houte K, Van den Branden C. Enalapril increases antioxidant enzyme activity in renal cortical tissue of five-sixths-nephrectomized rats. NEPHRON. 1998;80(2):214–9.
- IEEE
- [1]D. L. Verbeelen, D. De Craemer, P. Peeters, K. Vanden Houte, and C. Van den Branden, “Enalapril increases antioxidant enzyme activity in renal cortical tissue of five-sixths-nephrectomized rats,” NEPHRON, vol. 80, no. 2, pp. 214–219, 1998.
@article{887142, abstract = {{In rats with five-sixths nephrectomy (remnant kidney), blood pressure, glomerulosclerosis, and proteinuria are significantly reduced by administration of the angiotensin-converting enzyme inhibitor enalapril, during 16 weeks after reduction of the nephron number. The activity of catalase in remnant-kidney cortex homogenate is not influenced by enalapril treatment; the activities of superoxide dismutase and glutathione peroxidase are significantly increased. Elevated lipid peroxidation in cortex homogenates, evaluated by malondialdehyde and 4-hydroxynonenal concentrations, is not changed by treatment. Supplementation of dietary vitamin E to enalapril treatment does not alter antioxidant enzyme activities when compared to enalapril monotherapy. These results show that enalapril improves the balance between reactive oxygen intermediates and antioxidant enzymes in the remnant-kidney cortex of the rat. This finding may in part explain the protective effect of angiotensin-converting enzyme inhibitors on the progression of glomerulosclerosis.}}, author = {{Verbeelen, Dierik L and De Craemer, Dirk and Peeters, Patrick and Vanden Houte, Katherina and Van den Branden, Christiane}}, issn = {{0028-2766}}, journal = {{NEPHRON}}, keywords = {{enalapril,antioxidant enzymes,angiotensin-converting enzyme inhibitors,glomerulosclerosis,reactive oxygen intermediates,remnant kidney}}, language = {{eng}}, number = {{2}}, pages = {{214--219}}, title = {{Enalapril increases antioxidant enzyme activity in renal cortical tissue of five-sixths-nephrectomized rats}}, url = {{http://doi.org/10.1159/000045170}}, volume = {{80}}, year = {{1998}}, }
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