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Genetic susceptibility in solvent induced neurobehavioral effects

Lode Godderis, N Maertens, Virginie de Gelder UGent, A De Lamper, Kim De Ruyck UGent, M Vernimmen, S Bulterys, G Moens, Hubert Thierens UGent and MK Viaene (2010) NEUROTOXICITY RESEARCH. 17(3). p.268-278
abstract
The aim of this investigation was to study the influence of genetic polymorphisms of biotransformation enzymes and dopamine receptors on neurobehavioral effects in referents (n = 53), solvent-workers (n = 144), and chronic toxic encephalopathy (CTE) patients (n = 33). All participants were interviewed for exposure data and confounding factors and underwent a clinical examination. Neurobehavioral complaints (neurotoxicity symptom checklist-60) and effects [simple reaction time (SRT), symbol digit substitution (SDS), hand-eye coordination (HEC), and digit span backwards (DSB)] were evaluated with a computer assisted test battery. The following genotypes were determined: GSTM1, GSTT1, GSTP1, DRD2 Taq1A, DRD2 Taq1B, and DRD2-141Cdel. Neurotoxic effects and complaints were significantly higher in CTE patients and were related to both duration and level of exposure. An equal distribution of genotypes was found between all groups. Logistic regression analysis revealed that GSTT1 was negatively associated with sleep and sensorimotor complaints. GSTM1 had a protecting influence on the relationship between logDSB and the cumulative exposure index and between logSRT and cumulative exposure index and degree of exposure, respectively. This effect was also found when correcting for age, education level, alcohol consumption, and smoking. DRD2-141Cdel polymorphisms had a negative influence on the relationship between logSDS and the total exposure time. GSTT1 might be protective against sleep and sensorimotor complaints, whereas GSTM1 seems to decrease sustained attention and short-term memory problems in relation to solvent exposure. Individuals possessing DRD2-141Cdel variant experienced more visuomotor problems.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
POSITRON-EMISSION-TOMOGRAPHY, EPOXIDE HYDROLASE, STYRENE, GSTT1 POLYMORPHISMS, D2 RECEPTOR GENE, CHRONIC TOXIC ENCEPHALOPATHY, WORKERS, ENZYMES, EXPOSURE, PARKINSONS-DISEASE
journal title
NEUROTOXICITY RESEARCH
Neurotox. Res.
volume
17
issue
3
pages
268 - 278
Web of Science type
Article
Web of Science id
000273795100008
JCR category
NEUROSCIENCES
JCR impact factor
3.015 (2010)
JCR rank
106/235 (2010)
JCR quartile
2 (2010)
ISSN
1029-8428
DOI
10.1007/s12640-009-9100-7
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
879190
handle
http://hdl.handle.net/1854/LU-879190
date created
2010-02-24 14:56:34
date last changed
2010-09-15 16:29:36
@article{879190,
  abstract     = {The aim of this investigation was to study the influence of genetic polymorphisms of biotransformation enzymes and dopamine receptors on neurobehavioral effects in referents (n = 53), solvent-workers (n = 144), and chronic toxic encephalopathy (CTE) patients (n = 33). All participants were interviewed for exposure data and confounding factors and underwent a clinical examination. Neurobehavioral complaints (neurotoxicity symptom checklist-60) and effects [simple reaction time (SRT), symbol digit substitution (SDS), hand-eye coordination (HEC), and digit span backwards (DSB)] were evaluated with a computer assisted test battery. The following genotypes were determined: GSTM1, GSTT1, GSTP1, DRD2 Taq1A, DRD2 Taq1B, and DRD2-141Cdel. Neurotoxic effects and complaints were significantly higher in CTE patients and were related to both duration and level of exposure. An equal distribution of genotypes was found between all groups. Logistic regression analysis revealed that GSTT1 was negatively associated with sleep and sensorimotor complaints. GSTM1 had a protecting influence on the relationship between logDSB and the cumulative exposure index and between logSRT and cumulative exposure index and degree of exposure, respectively. This effect was also found when correcting for age, education level, alcohol consumption, and smoking. DRD2-141Cdel polymorphisms had a negative influence on the relationship between logSDS and the total exposure time. GSTT1 might be protective against sleep and sensorimotor complaints, whereas GSTM1 seems to decrease sustained attention and short-term memory problems in relation to solvent exposure. Individuals possessing DRD2-141Cdel variant experienced more visuomotor problems.},
  author       = {Godderis, Lode and Maertens, N and de Gelder, Virginie and De Lamper, A and De Ruyck, Kim and Vernimmen, M and Bulterys, S and Moens, G and Thierens, Hubert and Viaene, MK},
  issn         = {1029-8428},
  journal      = {NEUROTOXICITY RESEARCH},
  keyword      = {POSITRON-EMISSION-TOMOGRAPHY,EPOXIDE HYDROLASE,STYRENE,GSTT1 POLYMORPHISMS,D2 RECEPTOR GENE,CHRONIC TOXIC ENCEPHALOPATHY,WORKERS,ENZYMES,EXPOSURE,PARKINSONS-DISEASE},
  language     = {eng},
  number       = {3},
  pages        = {268--278},
  title        = {Genetic susceptibility in solvent induced neurobehavioral effects},
  url          = {http://dx.doi.org/10.1007/s12640-009-9100-7},
  volume       = {17},
  year         = {2010},
}

Chicago
Godderis, Lode, N Maertens, Virginie de Gelder, A De Lamper, Kim De Ruyck, M Vernimmen, S Bulterys, G Moens, Hubert Thierens, and MK Viaene. 2010. “Genetic Susceptibility in Solvent Induced Neurobehavioral Effects.” Neurotoxicity Research 17 (3): 268–278.
APA
Godderis, L., Maertens, N., de Gelder, V., De Lamper, A., De Ruyck, K., Vernimmen, M., Bulterys, S., et al. (2010). Genetic susceptibility in solvent induced neurobehavioral effects. NEUROTOXICITY RESEARCH, 17(3), 268–278.
Vancouver
1.
Godderis L, Maertens N, de Gelder V, De Lamper A, De Ruyck K, Vernimmen M, et al. Genetic susceptibility in solvent induced neurobehavioral effects. NEUROTOXICITY RESEARCH. 2010;17(3):268–78.
MLA
Godderis, Lode, N Maertens, Virginie de Gelder, et al. “Genetic Susceptibility in Solvent Induced Neurobehavioral Effects.” NEUROTOXICITY RESEARCH 17.3 (2010): 268–278. Print.