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Declining prevalence of SARS-CoV-2 antibodies among vaccinated nursing home residents and staff six months after the primary BNT162b2 vaccination campaign in Belgium : a prospective cohort study

Eline Meyers (UGent) , Ellen Deschepper (UGent) , Els Duysburgh, Liselore De Rop, Tine De Burghgraeve, Pauline Van Ngoc, Marina Digregorio, Simon Delogne, Anja Coen (UGent) , Nele De Clercq (UGent) , et al.
(2022) VIRUSES-BASEL. 14(11).
Author
Organization
Abstract
In the SCOPE study, we monitored SARS-CoV-2 antibodies in a national sample of residents and staff from Belgian nursing homes. Here, we report the seroprevalence among infected and infection-naive residents and staff after the primary COVID-19 vaccination campaign. Among 1554 vaccinated nursing home residents and 1082 vaccinated staff from 69 nursing homes in Belgium, we assessed the proportion having SARS-CoV-2 antibodies approximately two (April 2021), four (June 2021), and six months (August 2021) after a two-dose regimen of the BNT162b2 vaccine. We measured the seroprevalence using SARS-CoV-2 antibody rapid tests and collected socio-demographic and COVID-19 medical data using an online questionnaire. Two months after vaccination (baseline), we found a seroprevalence of 91% (95% CI: 89-93) among vaccinated residents and 99% (95% CI: 98-99) among vaccinated staff. Six months after vaccination, the seroprevalence significantly decreased to 68% (95% CI: 64-72) among residents and to 89% (95% CI; 86-91) among staff (p < 0.001). The seroprevalence was more likely to decrease among infection-naive residents, older residents, or residents with a high care dependency level. These findings emphasize the need for close monitoring of nursing home residents, as a substantial part of this population fails to mount a persistent antibody response after BNT162b2 vaccination.
Keywords
Virology, Infectious Diseases, BNT126b2, COVID-19 vaccination, elderly, nursing home residents, IgM, IgG, SARS-CoV-2, seroprevalence

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Citation

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MLA
Meyers, Eline, et al. “Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium : A Prospective Cohort Study.” VIRUSES-BASEL, vol. 14, no. 11, 2022, doi:10.3390/v14112361.
APA
Meyers, E., Deschepper, E., Duysburgh, E., De Rop, L., De Burghgraeve, T., Van Ngoc, P., … Heytens, S. (2022). Declining prevalence of SARS-CoV-2 antibodies among vaccinated nursing home residents and staff six months after the primary BNT162b2 vaccination campaign in Belgium : a prospective cohort study. VIRUSES-BASEL, 14(11). https://doi.org/10.3390/v14112361
Chicago author-date
Meyers, Eline, Ellen Deschepper, Els Duysburgh, Liselore De Rop, Tine De Burghgraeve, Pauline Van Ngoc, Marina Digregorio, et al. 2022. “Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium : A Prospective Cohort Study.” VIRUSES-BASEL 14 (11). https://doi.org/10.3390/v14112361.
Chicago author-date (all authors)
Meyers, Eline, Ellen Deschepper, Els Duysburgh, Liselore De Rop, Tine De Burghgraeve, Pauline Van Ngoc, Marina Digregorio, Simon Delogne, Anja Coen, Nele De Clercq, Laëtitia Buret, Samuel Coenen, An De Sutter, Beatrice Scholtes, Jan Y Verbakel, Piet Cools, and Stefan Heytens. 2022. “Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium : A Prospective Cohort Study.” VIRUSES-BASEL 14 (11). doi:10.3390/v14112361.
Vancouver
1.
Meyers E, Deschepper E, Duysburgh E, De Rop L, De Burghgraeve T, Van Ngoc P, et al. Declining prevalence of SARS-CoV-2 antibodies among vaccinated nursing home residents and staff six months after the primary BNT162b2 vaccination campaign in Belgium : a prospective cohort study. VIRUSES-BASEL. 2022;14(11).
IEEE
[1]
E. Meyers et al., “Declining prevalence of SARS-CoV-2 antibodies among vaccinated nursing home residents and staff six months after the primary BNT162b2 vaccination campaign in Belgium : a prospective cohort study,” VIRUSES-BASEL, vol. 14, no. 11, 2022.
@article{8772949,
  abstract     = {{In the SCOPE study, we monitored SARS-CoV-2 antibodies in a national sample of residents and staff from Belgian nursing homes. Here, we report the seroprevalence among infected and infection-naive residents and staff after the primary COVID-19 vaccination campaign. Among 1554 vaccinated nursing home residents and 1082 vaccinated staff from 69 nursing homes in Belgium, we assessed the proportion having SARS-CoV-2 antibodies approximately two (April 2021), four (June 2021), and six months (August 2021) after a two-dose regimen of the BNT162b2 vaccine. We measured the seroprevalence using SARS-CoV-2 antibody rapid tests and collected socio-demographic and COVID-19 medical data using an online questionnaire. Two months after vaccination (baseline), we found a seroprevalence of 91% (95% CI: 89-93) among vaccinated residents and 99% (95% CI: 98-99) among vaccinated staff. Six months after vaccination, the seroprevalence significantly decreased to 68% (95% CI: 64-72) among residents and to 89% (95% CI; 86-91) among staff (p < 0.001). The seroprevalence was more likely to decrease among infection-naive residents, older residents, or residents with a high care dependency level. These findings emphasize the need for close monitoring of nursing home residents, as a substantial part of this population fails to mount a persistent antibody response after BNT162b2 vaccination.}},
  articleno    = {{2361}},
  author       = {{Meyers, Eline and Deschepper, Ellen and Duysburgh, Els and De Rop, Liselore and De Burghgraeve, Tine and Van Ngoc, Pauline and Digregorio, Marina and Delogne, Simon and Coen, Anja and De Clercq, Nele and Buret, Laëtitia and Coenen, Samuel and De Sutter, An and Scholtes, Beatrice and Verbakel, Jan Y and Cools, Piet and Heytens, Stefan}},
  issn         = {{1999-4915}},
  journal      = {{VIRUSES-BASEL}},
  keywords     = {{Virology,Infectious Diseases,BNT126b2,COVID-19 vaccination,elderly,nursing home residents,IgM,IgG,SARS-CoV-2,seroprevalence}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{10}},
  title        = {{Declining prevalence of SARS-CoV-2 antibodies among vaccinated nursing home residents and staff six months after the primary BNT162b2 vaccination campaign in Belgium : a prospective cohort study}},
  url          = {{http://doi.org/10.3390/v14112361}},
  volume       = {{14}},
  year         = {{2022}},
}
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