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Alprazolam detection using an electrochemical nanobiosensor based on AuNUs/Fe-Ni@rGO nanocomposite

Emadoddin Amin Sadrabadi, Fatemeh Khosravi, Ali Benvidi, Amin Shiralizadeh Dezfuli, Pouria Khashayar, Patricia Khashayar (UGent) and Mostafa Azimzadeh
(2022) BIOSENSORS-BASEL. 12(11).
Author
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Abstract
Despite all the psychological advantages of alprazolam, its long list of toxic properties and interactions has caused concern and highlighted the need for a reliable sensing method. In this study, we developed a simple, highly sensitive electrochemical nanobiosensor to determine the desirable dose of alprazolam, averting the undesirable consequences of overdose. Gold nanourchins (AuNUs) and iron-nickel reduced graphene oxide (Fe-Ni@rGO) were immobilized on a glassy carbon electrode, which was treated beforehand. The electrode surface was characterized using cyclic voltammetry, Fourier transform infrared spectroscopy, scanning electron microscopy/energy-dispersive X-ray spectroscopy, and differential pulse voltammetry. The fabricated sensor showed two linear ranges (4 to 500 µg L−1 and 1 to 50 mg L−1), low limit of detection (1 µg L−1), high sensitivity, good repeatability, and good recovery. Increased –OH and carboxyl (-COOH) groups on the electrode surface, resulting in improved the adsorption of alprazolam and thus lower limit of detection. This nanobiosensor could detect alprazolam powder dissolved in diluted blood serum; we also studied other benzodiazepine drugs (clonazepam, oxazepam, and diazepam) with this nanobiosensor, and results were sensible, with a significant difference.
Keywords
Clinical Biochemistry, General Medicine, Analytical Chemistry, Biotechnology, Instrumentation, Biomedical Engineering, Engineering (miscellaneous)

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MLA
Sadrabadi, Emadoddin Amin, et al. “Alprazolam Detection Using an Electrochemical Nanobiosensor Based on AuNUs/Fe-Ni@rGO Nanocomposite.” BIOSENSORS-BASEL, vol. 12, no. 11, 2022, doi:10.3390/bios12110945.
APA
Sadrabadi, E. A., Khosravi, F., Benvidi, A., Shiralizadeh Dezfuli, A., Khashayar, P., Khashayar, P., & Azimzadeh, M. (2022). Alprazolam detection using an electrochemical nanobiosensor based on AuNUs/Fe-Ni@rGO nanocomposite. BIOSENSORS-BASEL, 12(11). https://doi.org/10.3390/bios12110945
Chicago author-date
Sadrabadi, Emadoddin Amin, Fatemeh Khosravi, Ali Benvidi, Amin Shiralizadeh Dezfuli, Pouria Khashayar, Patricia Khashayar, and Mostafa Azimzadeh. 2022. “Alprazolam Detection Using an Electrochemical Nanobiosensor Based on AuNUs/Fe-Ni@rGO Nanocomposite.” BIOSENSORS-BASEL 12 (11). https://doi.org/10.3390/bios12110945.
Chicago author-date (all authors)
Sadrabadi, Emadoddin Amin, Fatemeh Khosravi, Ali Benvidi, Amin Shiralizadeh Dezfuli, Pouria Khashayar, Patricia Khashayar, and Mostafa Azimzadeh. 2022. “Alprazolam Detection Using an Electrochemical Nanobiosensor Based on AuNUs/Fe-Ni@rGO Nanocomposite.” BIOSENSORS-BASEL 12 (11). doi:10.3390/bios12110945.
Vancouver
1.
Sadrabadi EA, Khosravi F, Benvidi A, Shiralizadeh Dezfuli A, Khashayar P, Khashayar P, et al. Alprazolam detection using an electrochemical nanobiosensor based on AuNUs/Fe-Ni@rGO nanocomposite. BIOSENSORS-BASEL. 2022;12(11).
IEEE
[1]
E. A. Sadrabadi et al., “Alprazolam detection using an electrochemical nanobiosensor based on AuNUs/Fe-Ni@rGO nanocomposite,” BIOSENSORS-BASEL, vol. 12, no. 11, 2022.
@article{8771830,
  abstract     = {{Despite all the psychological advantages of alprazolam, its long list of toxic properties and interactions has caused concern and highlighted the need for a reliable sensing method. In this study, we developed a simple, highly sensitive electrochemical nanobiosensor to determine the desirable dose of alprazolam, averting the undesirable consequences of overdose. Gold nanourchins (AuNUs) and iron-nickel reduced graphene oxide (Fe-Ni@rGO) were immobilized on a glassy carbon electrode, which was treated beforehand. The electrode surface was characterized using cyclic voltammetry, Fourier transform infrared spectroscopy, scanning electron microscopy/energy-dispersive X-ray spectroscopy, and differential pulse voltammetry. The fabricated sensor showed two linear ranges (4 to 500 µg L−1 and 1 to 50 mg L−1), low limit of detection (1 µg L−1), high sensitivity, good repeatability, and good recovery. Increased –OH and carboxyl (-COOH) groups on the electrode surface, resulting in improved the adsorption of alprazolam and thus lower limit of detection. This nanobiosensor could detect alprazolam powder dissolved in diluted blood serum; we also studied other benzodiazepine drugs (clonazepam, oxazepam, and diazepam) with this nanobiosensor, and results were sensible, with a significant difference.}},
  articleno    = {{945}},
  author       = {{Sadrabadi, Emadoddin Amin and Khosravi, Fatemeh and Benvidi, Ali and Shiralizadeh Dezfuli, Amin and Khashayar, Pouria and Khashayar, Patricia and Azimzadeh, Mostafa}},
  issn         = {{2079-6374}},
  journal      = {{BIOSENSORS-BASEL}},
  keywords     = {{Clinical Biochemistry,General Medicine,Analytical Chemistry,Biotechnology,Instrumentation,Biomedical Engineering,Engineering (miscellaneous)}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{15}},
  title        = {{Alprazolam detection using an electrochemical nanobiosensor based on AuNUs/Fe-Ni@rGO nanocomposite}},
  url          = {{http://doi.org/10.3390/bios12110945}},
  volume       = {{12}},
  year         = {{2022}},
}
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