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Bone parameters in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder : a comparative cross-sectional study

Marie Coussens (UGent) , Thiberiu Banica (UGent) , Bruno Lapauw (UGent) , Inge De Wandele (UGent) , Lies Rombaut (UGent) , Fransiska Malfait (UGent) and Patrick Calders (UGent)
(2023) BONE. 166.
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Abstract
Objective: To compare bone parameters between individuals with hypermobile Ehlers-Danlos syndrome (hEDS) and generalized joint hypermobility spectrum disorder (G-HSD), both diagnosed according to the most recent diagnostic criteria, and with controls. Methods: Twenty female adults with hEDS (mean age 43.8 years), 20 with G-HSD (mean age 41.8 years), and 37 healthy controls (mean age 40.8 years) participated. Body composition and bone parameters at whole body and lumbar spine were assessed by dual-energy X-ray absorptiometry. Peripheral quantitative computed tomography at the lower leg evaluated body composition (66 % site), and trabecular (4 % site) and cortical (66 % site) bone parameters at the tibia.Results: No significantly different body composition and bone parameters were observed between hEDS and G-HSD. Compared to controls, individuals with hEDS and G-HSD had lower muscle mass (p = 0.004 and p < 0.001, respectively) and cross-sectional area (p = 0.025 and p < 0.001, respectively), cortical bone mineral content (BMC; p = 0.024 and p = 0.027, respectively) and area (p = 0.019 and p = 0.010, respectively). Additionally, individuals with hEDS had lower muscle density (p = 0.009), trabecular BMC (p = 0.027) and bone mineral density (p = 0.022), and individuals with G-HSD lower stress-strain index (p = 0.019), and periosteal and endosteal circumference (p = 0.002 and 0.025, respectively), compared to controls.Conclusion: Results indicated lower cortical bone mineral content and smaller cortices in hEDS and G-HSD compared to controls. Individuals with hEDS and G-HSD had no different bone parameters, suggesting that these impairments might not be reflected by the different diagnostic classification. Therefore, we recommend regular physical activity, and training to reduce the risk of falling in both hEDS or G-HSD.
Keywords
Histology, Physiology, Endocrinology, Diabetes and Metabolism, Dual-energy X-ray absorptiometry, Hypermobility, Ehlers-Danlos syndrome, Bone

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MLA
Coussens, Marie, et al. “Bone Parameters in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder : A Comparative Cross-Sectional Study.” BONE, vol. 166, 2023, doi:10.1016/j.bone.2022.116583.
APA
Coussens, M., Banica, T., Lapauw, B., De Wandele, I., Rombaut, L., Malfait, F., & Calders, P. (2023). Bone parameters in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder : a comparative cross-sectional study. BONE, 166. https://doi.org/10.1016/j.bone.2022.116583
Chicago author-date
Coussens, Marie, Thiberiu Banica, Bruno Lapauw, Inge De Wandele, Lies Rombaut, Fransiska Malfait, and Patrick Calders. 2023. “Bone Parameters in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder : A Comparative Cross-Sectional Study.” BONE 166. https://doi.org/10.1016/j.bone.2022.116583.
Chicago author-date (all authors)
Coussens, Marie, Thiberiu Banica, Bruno Lapauw, Inge De Wandele, Lies Rombaut, Fransiska Malfait, and Patrick Calders. 2023. “Bone Parameters in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder : A Comparative Cross-Sectional Study.” BONE 166. doi:10.1016/j.bone.2022.116583.
Vancouver
1.
Coussens M, Banica T, Lapauw B, De Wandele I, Rombaut L, Malfait F, et al. Bone parameters in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder : a comparative cross-sectional study. BONE. 2023;166.
IEEE
[1]
M. Coussens et al., “Bone parameters in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder : a comparative cross-sectional study,” BONE, vol. 166, 2023.
@article{8770924,
  abstract     = {{Objective: To compare bone parameters between individuals with hypermobile Ehlers-Danlos syndrome (hEDS) and generalized joint hypermobility spectrum disorder (G-HSD), both diagnosed according to the most recent diagnostic criteria, and with controls. Methods: Twenty female adults with hEDS (mean age 43.8 years), 20 with G-HSD (mean age 41.8 years), and 37 healthy controls (mean age 40.8 years) participated. Body composition and bone parameters at whole body and lumbar spine were assessed by dual-energy X-ray absorptiometry. Peripheral quantitative computed tomography at the lower leg evaluated body composition (66 % site), and trabecular (4 % site) and cortical (66 % site) bone parameters at the tibia.Results: No significantly different body composition and bone parameters were observed between hEDS and G-HSD. Compared to controls, individuals with hEDS and G-HSD had lower muscle mass (p = 0.004 and p < 0.001, respectively) and cross-sectional area (p = 0.025 and p < 0.001, respectively), cortical bone mineral content (BMC; p = 0.024 and p = 0.027, respectively) and area (p = 0.019 and p = 0.010, respectively). Additionally, individuals with hEDS had lower muscle density (p = 0.009), trabecular BMC (p = 0.027) and bone mineral density (p = 0.022), and individuals with G-HSD lower stress-strain index (p = 0.019), and periosteal and endosteal circumference (p = 0.002 and 0.025, respectively), compared to controls.Conclusion: Results indicated lower cortical bone mineral content and smaller cortices in hEDS and G-HSD compared to controls. Individuals with hEDS and G-HSD had no different bone parameters, suggesting that these impairments might not be reflected by the different diagnostic classification. Therefore, we recommend regular physical activity, and training to reduce the risk of falling in both hEDS or G-HSD.}},
  articleno    = {{116583}},
  author       = {{Coussens, Marie and Banica, Thiberiu and Lapauw, Bruno and De Wandele, Inge and Rombaut, Lies and Malfait, Fransiska and Calders, Patrick}},
  issn         = {{8756-3282}},
  journal      = {{BONE}},
  keywords     = {{Histology,Physiology,Endocrinology,Diabetes and Metabolism,Dual-energy X-ray absorptiometry,Hypermobility,Ehlers-Danlos syndrome,Bone}},
  language     = {{eng}},
  pages        = {{7}},
  title        = {{Bone parameters in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder : a comparative cross-sectional study}},
  url          = {{http://doi.org/10.1016/j.bone.2022.116583}},
  volume       = {{166}},
  year         = {{2023}},
}
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