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Lateralized subgenual ACC metabolic connectivity patterns in refractory melancholic depression : does it matter?

Guo-Rong Wu and Chris Baeken (UGent)
(2023) CEREBRAL CORTEX. 33(7). p.3490-3497
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Abstract
Although treatment resistance to antidepressant pharmacotherapy is quite common, the phenomenon of refractory major depressive disorder (rMDD) is not well understood. Nevertheless, the metabolic activity of the subgenual anterior cingulate cortex (sgACC) has been put forward as a possible metabolic biomarker of clinical prediction and response, albeit sgACC lateralization differences in functional connectivity have not yet been extensively examined. Also not in the refractory depressed state. To examine sgACC lateralization differences in metabolic connectivity, we recruited 43 right-handed antidepressant-free unipolar melancholic rMDD patients and 32 right-handed healthy controls to participate in this (18)FDG PET study and developed a searchlight-based interregional covariance connectivity approach. Compared to non-depressed individuals, sgACC covariance analysis showed stronger metabolic connections with frontolimbic brain regions known to be affected in the depressed state. Furthermore, whereas the left sgACC showed stronger metabolic connections with ventromedial prefrontal cortical regions, implicated in anhedonia, suicidal ideation, and self-referential processes, the right sgACC showed significantly stronger metabolic connections with posterior hippocampal and cerebellar regions, respectively specialized in memory and social processing. Overall, our results substantiate earlier research that the sgACC is a metabolic key player when clinically depressed and that distinct lateralized sgACC metabolic connectivity patterns are present.
Keywords
Cellular and Molecular Neuroscience, Cognitive Neuroscience, covariance analysis, sgACC, 18FDG PET, major depression disorder, refractory

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MLA
Wu, Guo-Rong, and Chris Baeken. “Lateralized Subgenual ACC Metabolic Connectivity Patterns in Refractory Melancholic Depression : Does It Matter?” CEREBRAL CORTEX, vol. 33, no. 7, Oxford, 2023, pp. 3490–97, doi:10.1093/cercor/bhac286.
APA
Wu, G.-R., & Baeken, C. (2023). Lateralized subgenual ACC metabolic connectivity patterns in refractory melancholic depression : does it matter? CEREBRAL CORTEX, 33(7), 3490–3497. https://doi.org/10.1093/cercor/bhac286
Chicago author-date
Wu, Guo-Rong, and Chris Baeken. 2023. “Lateralized Subgenual ACC Metabolic Connectivity Patterns in Refractory Melancholic Depression : Does It Matter?” CEREBRAL CORTEX 33 (7): 3490–97. https://doi.org/10.1093/cercor/bhac286.
Chicago author-date (all authors)
Wu, Guo-Rong, and Chris Baeken. 2023. “Lateralized Subgenual ACC Metabolic Connectivity Patterns in Refractory Melancholic Depression : Does It Matter?” CEREBRAL CORTEX 33 (7): 3490–3497. doi:10.1093/cercor/bhac286.
Vancouver
1.
Wu G-R, Baeken C. Lateralized subgenual ACC metabolic connectivity patterns in refractory melancholic depression : does it matter? CEREBRAL CORTEX. 2023;33(7):3490–7.
IEEE
[1]
G.-R. Wu and C. Baeken, “Lateralized subgenual ACC metabolic connectivity patterns in refractory melancholic depression : does it matter?,” CEREBRAL CORTEX, vol. 33, no. 7, pp. 3490–3497, 2023.
@article{8770195,
  abstract     = {{Although treatment resistance to antidepressant pharmacotherapy is quite common, the phenomenon of refractory major depressive disorder (rMDD) is not well understood. Nevertheless, the metabolic activity of the subgenual anterior cingulate cortex (sgACC) has been put forward as a possible metabolic biomarker of clinical prediction and response, albeit sgACC lateralization differences in functional connectivity have not yet been extensively examined. Also not in the refractory depressed state. To examine sgACC lateralization differences in metabolic connectivity, we recruited 43 right-handed antidepressant-free unipolar melancholic rMDD patients and 32 right-handed healthy controls to participate in this (18)FDG PET study and developed a searchlight-based interregional covariance connectivity approach. Compared to non-depressed individuals, sgACC covariance analysis showed stronger metabolic connections with frontolimbic brain regions known to be affected in the depressed state. Furthermore, whereas the left sgACC showed stronger metabolic connections with ventromedial prefrontal cortical regions, implicated in anhedonia, suicidal ideation, and self-referential processes, the right sgACC showed significantly stronger metabolic connections with posterior hippocampal and cerebellar regions, respectively specialized in memory and social processing. Overall, our results substantiate earlier research that the sgACC is a metabolic key player when clinically depressed and that distinct lateralized sgACC metabolic connectivity patterns are present.}},
  author       = {{Wu, Guo-Rong and Baeken, Chris}},
  issn         = {{1047-3211}},
  journal      = {{CEREBRAL CORTEX}},
  keywords     = {{Cellular and Molecular Neuroscience,Cognitive Neuroscience,covariance analysis,sgACC,18FDG PET,major depression disorder,refractory}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{3490--3497}},
  publisher    = {{Oxford}},
  title        = {{Lateralized subgenual ACC metabolic connectivity patterns in refractory melancholic depression : does it matter?}},
  url          = {{http://doi.org/10.1093/cercor/bhac286}},
  volume       = {{33}},
  year         = {{2023}},
}
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