@article{8769760,
  abstract     = {{Metabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In the in vitro fertilisation clinic, maternal metabolic disorders are linked with disappointing assisted reproductive technology results. Embryos derived from metabolically compromised oocytes exhibit persistently high intracellular stress levels due to weak cellular homeostatic mechanisms. The assisted reproductive technology procedures themselves form an extra burden for these defective embryos. Minimising cellular stress during culture using mitochondrial-targeted therapy could rescue compromised embryos in a bovine model. However, translating such applications to human in vitro fertilisation clinics is not simple. It is crucial to consider the sensitive epigenetic programming during early development. Research in humans and relevant animal models should result in preconception care interventions and in vitro strategies not only aiming at improving fertility but also safeguarding offspring health.}},
  author       = {{Leroy, J. L. M. R. and Meulders, B. and Moorkens, K. and Xhonneux, I. and Slootmans, J. and De Keersmaeker, L. and Smits, A. and Bogado Pascottini, Osvaldo Américo and Marei, W. F. A.}},
  isbn         = {{1448-5990}},
  issn         = {{1031-3613}},
  journal      = {{REPRODUCTION FERTILITY AND DEVELOPMENT}},
  keywords     = {{Developmental Biology,Endocrinology,Genetics,Molecular Biology,Animal Science and Zoology,Reproductive Medicine,Biotechnology,antioxidant,assisted reproduction,epigenetic programming,maternal metabolic health,mitochondria targeted therapy,oocyte mitochondria,oocyte quality,preconception care interventions,ENDOPLASMIC-RETICULUM STRESS,FATTY-ACID CONCENTRATIONS,NEGATIVE-ENERGY BALANCE,YIELDING DAIRY-COWS,EARLY EMBRYONIC-DEVELOPMENT,IN-VITRO MATURATION,FOLLICULAR-FLUID,HEAT-STRESS,OXIDATIVE-STRESS,VITAMIN-E}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{1--18}},
  title        = {{Maternal metabolic health and fertility : we should not only care about but also for the oocyte!}},
  url          = {{http://doi.org/10.1071/rd22204}},
  volume       = {{35}},
  year         = {{2022}},
}

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