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TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy

Chengyang Li, Patrick Duckney, Tong Zhang, Yanshu Fu, Xin Li, Johan Kroon, Geert De Jaeger (UGent) , Yunjiang Cheng, Patrick J. Hussey and Pengwei Wang
(2022) NATURE COMMUNICATIONS. 13(1).
Author
Organization
Abstract
ER-mitochondrial contact sites (EMCSs) are important for mitochondrial function. Here, we have identified a EMCS complex, comprising a family of uncharacterised mitochondrial outer membrane proteins, TRB1, TRB2, and the ER protein, VAP27-1. In Arabidopsis, there are three TraB family isoforms and the trb1/trb2 double mutant exhibits abnormal mitochondrial morphology, strong starch accumulation, and impaired energy metabolism, indicating that these proteins are essential for normal mitochondrial function. Moreover, TRB1 and TRB2 proteins also interact with ATG8 in order to regulate mitochondrial degradation (mitophagy). The turnover of depolarised mitochondria is significantly reduced in both trb1/trb2 and VAP27 mutants (vap27-1,3,4,6) under mitochondrial stress conditions, with an increased population of dysfunctional mitochondria present in the cytoplasm. Consequently, plant recovery after stress is significantly perturbed, suggesting that TRB1-regulated mitophagy and ER-mitochondrial interaction are two closely related processes. Taken together, we ascribe a dual role to TraB family proteins which are component of the EMCS complex in eukaryotes, regulating both interaction of the mitochondria to the ER and mitophagy.
Keywords
General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary, ENDOPLASMIC-RETICULUM, PLASMA-MEMBRANE, ARABIDOPSIS, AUTOPHAGY, PROLIFERATION, METABOLISM, GENERATION, DATABASE, VAP27-1, PLANTS

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Citation

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MLA
Li, Chengyang, et al. “TraB Family Proteins Are Components of ER-Mitochondrial Contact Sites and Regulate ER-Mitochondrial Interactions and Mitophagy.” NATURE COMMUNICATIONS, vol. 13, no. 1, 2022, doi:10.1038/s41467-022-33402-w.
APA
Li, C., Duckney, P., Zhang, T., Fu, Y., Li, X., Kroon, J., … Wang, P. (2022). TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy. NATURE COMMUNICATIONS, 13(1). https://doi.org/10.1038/s41467-022-33402-w
Chicago author-date
Li, Chengyang, Patrick Duckney, Tong Zhang, Yanshu Fu, Xin Li, Johan Kroon, Geert De Jaeger, Yunjiang Cheng, Patrick J. Hussey, and Pengwei Wang. 2022. “TraB Family Proteins Are Components of ER-Mitochondrial Contact Sites and Regulate ER-Mitochondrial Interactions and Mitophagy.” NATURE COMMUNICATIONS 13 (1). https://doi.org/10.1038/s41467-022-33402-w.
Chicago author-date (all authors)
Li, Chengyang, Patrick Duckney, Tong Zhang, Yanshu Fu, Xin Li, Johan Kroon, Geert De Jaeger, Yunjiang Cheng, Patrick J. Hussey, and Pengwei Wang. 2022. “TraB Family Proteins Are Components of ER-Mitochondrial Contact Sites and Regulate ER-Mitochondrial Interactions and Mitophagy.” NATURE COMMUNICATIONS 13 (1). doi:10.1038/s41467-022-33402-w.
Vancouver
1.
Li C, Duckney P, Zhang T, Fu Y, Li X, Kroon J, et al. TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy. NATURE COMMUNICATIONS. 2022;13(1).
IEEE
[1]
C. Li et al., “TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy,” NATURE COMMUNICATIONS, vol. 13, no. 1, 2022.
@article{8768823,
  abstract     = {{ER-mitochondrial contact sites (EMCSs) are important for mitochondrial function. Here, we have identified a EMCS complex, comprising a family of uncharacterised mitochondrial outer membrane proteins, TRB1, TRB2, and the ER protein, VAP27-1. In Arabidopsis, there are three TraB family isoforms and the trb1/trb2 double mutant exhibits abnormal mitochondrial morphology, strong starch accumulation, and impaired energy metabolism, indicating that these proteins are essential for normal mitochondrial function. Moreover, TRB1 and TRB2 proteins also interact with ATG8 in order to regulate mitochondrial degradation (mitophagy). The turnover of depolarised mitochondria is significantly reduced in both trb1/trb2 and VAP27 mutants (vap27-1,3,4,6) under mitochondrial stress conditions, with an increased population of dysfunctional mitochondria present in the cytoplasm. Consequently, plant recovery after stress is significantly perturbed, suggesting that TRB1-regulated mitophagy and ER-mitochondrial interaction are two closely related processes. Taken together, we ascribe a dual role to TraB family proteins which are component of the EMCS complex in eukaryotes, regulating both interaction of the mitochondria to the ER and mitophagy.}},
  articleno    = {{5658}},
  author       = {{Li, Chengyang and Duckney, Patrick and Zhang, Tong and Fu, Yanshu and Li, Xin and Kroon, Johan and De Jaeger, Geert and Cheng, Yunjiang and Hussey, Patrick J. and Wang, Pengwei}},
  issn         = {{2041-1723}},
  journal      = {{NATURE COMMUNICATIONS}},
  keywords     = {{General Physics and Astronomy,General Biochemistry,Genetics and Molecular Biology,General Chemistry,Multidisciplinary,ENDOPLASMIC-RETICULUM,PLASMA-MEMBRANE,ARABIDOPSIS,AUTOPHAGY,PROLIFERATION,METABOLISM,GENERATION,DATABASE,VAP27-1,PLANTS}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{16}},
  title        = {{TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy}},
  url          = {{http://doi.org/10.1038/s41467-022-33402-w}},
  volume       = {{13}},
  year         = {{2022}},
}
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