@article{8768797,
  abstract     = {{Background: Frailty and hypertension are interrelated, but it remains unclear whether this relationship is modifed by antihypertensive drugs.
Methods and results: A systematic review of PubMed and Web of Science databases was performed to review the infuence of hypertension management on preventing the occurrence or progression of frailty in older people aged 65 and over. Studies providing information on this association regardless of the study setting, or defnition of hypertension and frailty were included. Among the initial 2298 articles identifed, 7 were included in the review. Three observational studies assessed the association between frailty and hypertension. Two of them reported no relationship between Aldosterone Antagonists use and frailty prevention. No relationship between BP and incidence frailty after adjustment for hypertension treatment was observed in two other articles. An indirect relationship was reported in the RCTs included. Higher AT11RaAb levels (control group), can lead to a generalized weakness/frailty risk shown by a decrease in grip strength (r=–0.57, p<0.005) and walking speed (r=– 0.47, p<0.005). No signifcant diferences between int-hypertensive intervention and control were observed in frailty status after a 12-weeks follow-up after applying three diferent frailty measurement tools in the other RCT.
Conclusions: Based on the results of this systematic review we conclude that BP and frailty occur together but whether the treatment with anti-hypertensive drugs modifes this relationship remains unclear and needs to be further investigated.}},
  author       = {{Qipo, Orgesa and Debain, Aziz and Bautmans, Ivan and on behalf of the Gerontopole Brussels Study Group, [missing] and Verté, Dominque and Beyer, Ingo and Petrovic, Mirko and De Witte, Nico and Kardol, Tinie and Rossi, Gina and Clarys, Peter and Scafoglieri, Aldo and Cattrysse, Erik and de Hert, Paul and Jansen, Bart}},
  issn         = {{1594-0667}},
  journal      = {{AGING CLINICAL AND EXPERIMENTAL RESEARCH}},
  keywords     = {{hypertension,antihypertensive agent,aged,frail,systematic review}},
  language     = {{eng}},
  pages        = {{2645--2657}},
  title        = {{The influence of hypertension management on frailty prevention among older persons aged 65 and over : a systematic review}},
  url          = {{http://doi.org/10.1007/s40520-022-02247-0}},
  volume       = {{34}},
  year         = {{2022}},
}

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