@article{8768472,
  abstract     = {{Background: our aim was to assess the effectiveness of medication review and deprescribing interventions as a single
intervention in falls prevention.
Methods:
Design: systematic review and meta-analysis.
Data sources: Medline, Embase, Cochrane CENTRAL, PsycINFO until 28 March 2022.
Eligibility criteria: randomised controlled trials of older participants comparing any medication review or deprescribing
intervention with usual care and reporting falls as an outcome.
Study records: title/abstract and full-text screening by two reviewers.
Risk of bias: Cochrane Collaboration revised tool.
Data synthesis: results reported separately for different settings and sufficiently comparable studies meta-analysed.
Results forty-nine heterogeneous studies were included.
Community: meta-analyses of medication reviews resulted in a risk ratio (RR) of 1.05 (95% confidence interval, 0.85–1.29,
I2 = 0%, 3 studies(s)) for number of fallers, in an RR = 0.95 (0.70–1.27, I2 = 37%, 3 s) for number of injurious fallers and
in a rate ratio (RaR) of 0.89 (0.69–1.14, I2 = 0%, 2 s) for injurious falls.
Hospital: meta-analyses assessing medication reviews resulted in an RR = 0.97 (0.74–1.28, I2 = 15%, 2 s) and in an
RR = 0.50 (0.07–3.50, I2 = 72% %, 2 s) for number of fallers after and during admission, respectively.
Long-term care: meta-analyses investigating medication reviews or deprescribing plans resulted in an RR = 0.86 (0.72–1.02, I2 = 0%, 5 s) for number of fallers and in an RaR = 0.93 (0.64–1.35, I2 = 92%, 7 s) for number of falls.
Conclusions: the heterogeneity of the interventions precluded us to estimate the exact effect of medication review and
deprescribing as a single intervention. For future studies, more comparability is warranted. These interventions should not be implemented as a stand-alone strategy in falls prevention but included in multimodal strategies due to the multifactorial nature of falls. PROSPERO registration number: CRD42020218231}},
  articleno    = {{afac191}},
  author       = {{Seppala, Lotta J and Kamkar, Nellie and van Poelgeest, Eveline P and Thomsen, Katja and Daams, Joost G and Ryg, Jesper and Masud, Tahir and Montero-Odasso, Manuel and Hartikainen, Sirpa and Petrovic, Mirko and van der Velde, Nathalie and Nieuwboer, Alice and Vlaeyen, Ellen and Milisen, Koen and Kenny, Rose Anne and Bourke, Robert and Van der Cammen, Tischa and Jellema, Anton and Todd, Chris and Martin, Finbarr C and Marsh, David R and Lamb, Sallie and Frith, James and Logan, Pip and Skelton, Dawn and Blain, Hubert and Anweiller, Cedric and Freiberger, Ellen and Becker, Clemens and Chiari, Lorenzo and Cesari, Matteo and Casas-Herrero, Alvaro and Perez Jara, Javier and Alonzo Bouzòn, Christina and Welmer, Ana-Karim and Birnghebuam, Stephanie and Kressig, Reto and Montero-Odasso, Manuel and Speechley, Mark and McIlroy, Bill and Faria, Frederico and Sultana, Munira and Muir-Hunter, Susan and Camicioli, Richard and Madden, Kenneth and Norris, Mireille and Watt, Jennifer and Mallet, Louise and Hogan, David and Verghese, Joe and Sejdic, Ervin and Ferruci, Luigi and Lipsitz, Lewis and Ganz, David A and Alexander, Neil B and Latham, Nancy Kathryn and Giber, Fabiana and Schapira, Marcelo and Jauregui, Ricardo and Melgar-Cuellar, Felipe and Alves Lourenço, Roberto and Carvalho de Abreu, Daniela Cristina and Perracini, Monica and Ceriani, Alejandro and Marín-Larraín, Pedro and Espinola, Homero Gac and Gómez-Montes, José Fernando and Cano-Gutierrez, Carlos Alberto and Ulate, Xinia Ramirez and Picado Ovares, José Ernesto and Gabriel Buendia, Patricio and Tito, Susana Lucia and Padilla, Diego Martínez and Aguilar-Navarro, Sara G and Mimenza, Alberto and Moctezum, Rogelio and Avila-Funes, Alberto and Gutiérrez-Robledo, Luis Miguel and Cornejo Alemán, Luis Manuel and Caona, Edgar Aguilera and Carbajal, Juan Carlos and Parodi, José F and Sgaravatti, Aldo and Lord, Stephen and Sherrington, Cathie and Said, Cathy and Cameron, Ian and Morris, Meg and Duque, Gustavo and Close, Jacqueline and Kerse, Ngaire and Tan, Maw Pin and Duan, Leilei and Sakurai, Ryota and Wong, Chek Hooi and Muneeb, Irfan and Negahban, Hossein and Birimoglu, Canan and Won, Chang Won and Huasdorff, Jeffrey and Kalula, Sebastiana and Kobusingye, Olive and the Task Force on Global Guidelines for Falls in Older Adults, [missing]}},
  issn         = {{0002-0729}},
  journal      = {{AGE AND AGEING}},
  keywords     = {{accidental falls,medication review,deprescribing,fall-risk-increasing drugs,older people,systematic review}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{12}},
  title        = {{Medication reviews and deprescribing as a single intervention in falls prevention : a systematic review and meta-analysis}},
  url          = {{http://doi.org/10.1093/ageing/afac191}},
  volume       = {{51}},
  year         = {{2022}},
}

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