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Prevalence and management of drug interactions between nonsteroidal anti-inflammatory drugs and antithrombotics in ambulatory care

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Abstract
Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and antithrombotic agents is associated with increased risks of both bleeding and thromboembolism. In this prospective intervention study, community pharmacists screened for NSAID-antithrombotic interactions and contacted the prescribing physician to discuss interaction management. We included 782 interactions; these were found in an older, polymedicated patient population (mean age: 68 y, median of 5 other drugs). Ibuprofen (in 43.0% of cases) and low-dose aspirin (78.8%) were the most frequently involved NSAID and antithrombotic, respectively. Anticoagulants were involved in 16.1% of interaction cases. For 61% of cases, the interacting drugs were prescribed by the same physician. The pharmacist-physician discussion about how to manage the interaction mostly resulted in no change of pharmacotherapy (60.7%); the most frequent reason given by physicians was that the NSAID was for short-term use only. In 39.3% of cases the discussion resulted in a pharmacotherapy change; replacing the NSAID by paracetamol was the most common change.
Keywords
THERAPY, RISK, NSAIDS, antithrombotic therapy, drug-drug interactions, nonsteroidal, anti-inflammatory drugs, safety

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MLA
Mehuys, Els, et al. “Prevalence and Management of Drug Interactions between Nonsteroidal Anti-Inflammatory Drugs and Antithrombotics in Ambulatory Care.” BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol. 88, no. 8, 2022, pp. 3896–902, doi:10.1111/bcp.15288.
APA
Mehuys, E., De Backer, T., De Keyser, F., Christiaens, T., Van Hees, T., Demarche, S., … Boussery, K. (2022). Prevalence and management of drug interactions between nonsteroidal anti-inflammatory drugs and antithrombotics in ambulatory care. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 88(8), 3896–3902. https://doi.org/10.1111/bcp.15288
Chicago author-date
Mehuys, Els, Tine De Backer, Filip De Keyser, Thierry Christiaens, Thierry Van Hees, Sophie Demarche, Inge Van Tongelen, and Koen Boussery. 2022. “Prevalence and Management of Drug Interactions between Nonsteroidal Anti-Inflammatory Drugs and Antithrombotics in Ambulatory Care.” BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 88 (8): 3896–3902. https://doi.org/10.1111/bcp.15288.
Chicago author-date (all authors)
Mehuys, Els, Tine De Backer, Filip De Keyser, Thierry Christiaens, Thierry Van Hees, Sophie Demarche, Inge Van Tongelen, and Koen Boussery. 2022. “Prevalence and Management of Drug Interactions between Nonsteroidal Anti-Inflammatory Drugs and Antithrombotics in Ambulatory Care.” BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 88 (8): 3896–3902. doi:10.1111/bcp.15288.
Vancouver
1.
Mehuys E, De Backer T, De Keyser F, Christiaens T, Van Hees T, Demarche S, et al. Prevalence and management of drug interactions between nonsteroidal anti-inflammatory drugs and antithrombotics in ambulatory care. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2022;88(8):3896–902.
IEEE
[1]
E. Mehuys et al., “Prevalence and management of drug interactions between nonsteroidal anti-inflammatory drugs and antithrombotics in ambulatory care,” BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol. 88, no. 8, pp. 3896–3902, 2022.
@article{8767492,
  abstract     = {{Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and antithrombotic agents is associated with increased risks of both bleeding and thromboembolism. In this prospective intervention study, community pharmacists screened for NSAID-antithrombotic interactions and contacted the prescribing physician to discuss interaction management. We included 782 interactions; these were found in an older, polymedicated patient population (mean age: 68 y, median of 5 other drugs). Ibuprofen (in 43.0% of cases) and low-dose aspirin (78.8%) were the most frequently involved NSAID and antithrombotic, respectively. Anticoagulants were involved in 16.1% of interaction cases. For 61% of cases, the interacting drugs were prescribed by the same physician. The pharmacist-physician discussion about how to manage the interaction mostly resulted in no change of pharmacotherapy (60.7%); the most frequent reason given by physicians was that the NSAID was for short-term use only. In 39.3% of cases the discussion resulted in a pharmacotherapy change; replacing the NSAID by paracetamol was the most common change.}},
  author       = {{Mehuys, Els and De Backer, Tine and De Keyser, Filip and Christiaens, Thierry and Van Hees, Thierry and Demarche, Sophie and Van Tongelen, Inge and Boussery, Koen}},
  issn         = {{0306-5251}},
  journal      = {{BRITISH JOURNAL OF CLINICAL PHARMACOLOGY}},
  keywords     = {{THERAPY,RISK,NSAIDS,antithrombotic therapy,drug-drug interactions,nonsteroidal,anti-inflammatory drugs,safety}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{3896--3902}},
  title        = {{Prevalence and management of drug interactions between nonsteroidal anti-inflammatory drugs and antithrombotics in ambulatory care}},
  url          = {{http://dx.doi.org/10.1111/bcp.15288}},
  volume       = {{88}},
  year         = {{2022}},
}

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