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Lung function impairment in relation to cognition and vascular brain lesions : the Rotterdam Study

Tian Xiao, Sara Wijnant, Isabelle van der Velpen, Natalie Terzikhan, Lies Lahousse (UGent) , M. Kamran Ikram, Meike W Vernooij, Guy Brusselle (UGent) and M. Arfan Ikram
(2022) JOURNAL OF NEUROLOGY. 269(8). p.4141-4153
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Abstract
Objective To investigate the association of chronic obstructive pulmonary disease (COPD) and Preserved Ratio Impaired Spirometry (PRISm) with cognitive performance and presence of vascular brain lesions (VBL). Methods We determined both cross-sectional and longitudinal association of lung function impairment with cognition, as well as cross-sectional association of lung function impairment with VBL, in the general population. Between 2009 and 2014 we included 3,941 participants from the Rotterdam Study with spirometry tests, brain MRI scans and cognition tests, of whom 1815 had follow-up data on cognition. Results Our finding indicated that cross-sectionally, participants with PRISm or COPD GOLD2-4 had a worse global cognitive performance. We did not find differences in cognition over time between those with normal spirometry versus those with lung function impairment. In addition, PRISm and COPD GOLD2-4 were associated with a higher prevalence of lacunar infarcts compared to normal spirometry. Conclusions This study suggests that persons with COPD GOLD2-4 or restrictive lung function, defined as PRISm, are characterized by poorer global cognitive function and a higher prevalence of lacunar infarcts.
Keywords
OBSTRUCTIVE PULMONARY-DISEASE, ATHEROSCLEROSIS RISK, POSSIBLE, ASSOCIATIONS, CEREBRAL MICROBLEEDS, ATRIAL-FIBRILLATION, LATE-LIFE, DEMENTIA, DECLINE, COPD, ISCHEMIA, PRISm, Lung function, COPD, Vascular brain lesions, Cognition

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MLA
Xiao, Tian, et al. “Lung Function Impairment in Relation to Cognition and Vascular Brain Lesions : The Rotterdam Study.” JOURNAL OF NEUROLOGY, vol. 269, no. 8, 2022, pp. 4141–53, doi:10.1007/s00415-022-11027-9.
APA
Xiao, T., Wijnant, S., van der Velpen, I., Terzikhan, N., Lahousse, L., Ikram, M. K., … Ikram, M. A. (2022). Lung function impairment in relation to cognition and vascular brain lesions : the Rotterdam Study. JOURNAL OF NEUROLOGY, 269(8), 4141–4153. https://doi.org/10.1007/s00415-022-11027-9
Chicago author-date
Xiao, Tian, Sara Wijnant, Isabelle van der Velpen, Natalie Terzikhan, Lies Lahousse, M. Kamran Ikram, Meike W Vernooij, Guy Brusselle, and M. Arfan Ikram. 2022. “Lung Function Impairment in Relation to Cognition and Vascular Brain Lesions : The Rotterdam Study.” JOURNAL OF NEUROLOGY 269 (8): 4141–53. https://doi.org/10.1007/s00415-022-11027-9.
Chicago author-date (all authors)
Xiao, Tian, Sara Wijnant, Isabelle van der Velpen, Natalie Terzikhan, Lies Lahousse, M. Kamran Ikram, Meike W Vernooij, Guy Brusselle, and M. Arfan Ikram. 2022. “Lung Function Impairment in Relation to Cognition and Vascular Brain Lesions : The Rotterdam Study.” JOURNAL OF NEUROLOGY 269 (8): 4141–4153. doi:10.1007/s00415-022-11027-9.
Vancouver
1.
Xiao T, Wijnant S, van der Velpen I, Terzikhan N, Lahousse L, Ikram MK, et al. Lung function impairment in relation to cognition and vascular brain lesions : the Rotterdam Study. JOURNAL OF NEUROLOGY. 2022;269(8):4141–53.
IEEE
[1]
T. Xiao et al., “Lung function impairment in relation to cognition and vascular brain lesions : the Rotterdam Study,” JOURNAL OF NEUROLOGY, vol. 269, no. 8, pp. 4141–4153, 2022.
@article{8767488,
  abstract     = {{Objective To investigate the association of chronic obstructive pulmonary disease (COPD) and Preserved Ratio Impaired Spirometry (PRISm) with cognitive performance and presence of vascular brain lesions (VBL). Methods We determined both cross-sectional and longitudinal association of lung function impairment with cognition, as well as cross-sectional association of lung function impairment with VBL, in the general population. Between 2009 and 2014 we included 3,941 participants from the Rotterdam Study with spirometry tests, brain MRI scans and cognition tests, of whom 1815 had follow-up data on cognition. Results Our finding indicated that cross-sectionally, participants with PRISm or COPD GOLD2-4 had a worse global cognitive performance. We did not find differences in cognition over time between those with normal spirometry versus those with lung function impairment. In addition, PRISm and COPD GOLD2-4 were associated with a higher prevalence of lacunar infarcts compared to normal spirometry. Conclusions This study suggests that persons with COPD GOLD2-4 or restrictive lung function, defined as PRISm, are characterized by poorer global cognitive function and a higher prevalence of lacunar infarcts.}},
  author       = {{Xiao, Tian and Wijnant, Sara and van der Velpen, Isabelle and Terzikhan, Natalie and Lahousse, Lies and Ikram, M. Kamran and Vernooij, Meike W and Brusselle, Guy and Ikram, M. Arfan}},
  issn         = {{0340-5354}},
  journal      = {{JOURNAL OF NEUROLOGY}},
  keywords     = {{OBSTRUCTIVE PULMONARY-DISEASE,ATHEROSCLEROSIS RISK,POSSIBLE,ASSOCIATIONS,CEREBRAL MICROBLEEDS,ATRIAL-FIBRILLATION,LATE-LIFE,DEMENTIA,DECLINE,COPD,ISCHEMIA,PRISm,Lung function,COPD,Vascular brain lesions,Cognition}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{4141--4153}},
  title        = {{Lung function impairment in relation to cognition and vascular brain lesions : the Rotterdam Study}},
  url          = {{http://doi.org/10.1007/s00415-022-11027-9}},
  volume       = {{269}},
  year         = {{2022}},
}
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