@article{8766824,
  abstract     = {{Objectives Rheumatoid factor (RF) is a well-established marker for the diagnosis and classification of rheumatoid arthritis (RA). Most studies evaluated IgM RF or isotype-nonspecific total RF assays. We evaluated the added value of IgA RF in this context. Methods An international sample cohort consisting of samples from 398 RA patients and 1073 controls was tested for IgA RF with 3 commercial assays. For all RA patients and 100 controls essential clinical and serological data for ACR/EULAR classification were available. Results The sensitivity of IgA RF for diagnosing RA was lower than the sensitivity of IgM RF. Differences in numerical values between IgA RF assays were observed. With all assays, the highest IgA RF values were found in patients with primary Sjogren's syndrome. Double positivity for IgM RF and IgA RF had a higher specificity for RA than either IgM RF or IgA RF. The sensitivity of double positivity was lower than the sensitivity of either IgA RF or IgM RF. Single positivity for IgA RF was at least as prevalent in controls than in RA patients. Adding IgA RF to IgM RF and anti-citrullinated protein antibodies (ACPA) did not affect RA classification. However, combined positivity for IgA RF, IgM RF and IgG ACPA had a higher specificity and lower sensitivity for RA classification than positivity for either of the antibodies. Conclusions IgA RF showed a lower sensitivity than IgM RF. Combining IgA RF with IgM RF and ACPA did not improve sensitivity of RA classification. Combined positivity (IgA-RF/IgM-RF/ACPA) increased specificity.}},
  author       = {{Van Hoovels, Lieve and Vander Cruyssen, Bert and Sieghart, Daniela and Bonroy, Carolien and Nagy, Eszter and Pullerits, Rille and Cucnik, Sasa and Dahle, Charlotte and Heijnen, Ingmar and Bernasconi, Luca and Benkhadra, Farid and Bogaert, Laura and Van den Bremt, Stefanie and Van Liedekerke, Ann and Vanheule, Geert and Robbrecht, Johan and Studholme, Lucy and Wirth, Claudine and Mueller, Ruediger and Kyburz, Diego and Sjowall, Christopher and Kastbom, Alf and Jese, Rok and Jovancevic, Boja and Kiss, Emese and Jacques, Peggy and Aletaha, Daniel and Steiner, Guenter and Verschueren, Patrick and Bossuyt, Xavier}},
  issn         = {{1434-6621}},
  journal      = {{CLINICAL CHEMISTRY AND LABORATORY MEDICINE}},
  keywords     = {{area under the receiver operating characteristics curve,harmonization,isotype,likelihood ratio,rheumatoid arthritis,rheumatoid factor,CYCLIC CITRULLINATED PEPTIDE,FACTOR ISOTYPES,ANTIBODIES,CLASSIFICATION,SPECIFICITY,DIAGNOSIS,RESPONSES,CRITERIA,PREDICT}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1617--1626}},
  title        = {{IgA rheumatoid factor in rheumatoid arthritis}},
  url          = {{http://doi.org/10.1515/cclm-2022-0244}},
  volume       = {{60}},
  year         = {{2022}},
}

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