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Exopolysaccharide from the yeast Papiliotrema terrestris PT22AV for skin wound healing

Masoud Hamidi, Oseweuba Valentine Okoro, Giuseppe Ianiri, Hafez Jafari, Khodabakhsh Rashidi, Saeed Ghasemi, Raffaello Castoria, Davide Palmieri, Cédric Delattre, Guillaume Pierre, et al.
(2023) JOURNAL OF ADVANCED RESEARCH. 46. p.61-74
Author
Organization
Abstract
Introduction: Exopolysaccharides (EPSs) are high-value functional biomaterials mainly produced by bac-teria and fungi, with nutraceutical, therapeutic and industrial potentials.Objectives: This study sought to characterize and assess the biological properties of the EPS produced by the yeast Papiliotrema terrestris PT22AV.Methods: After extracting the yeast's DNA and its molecular identification, the EPS from P. terrestris PT22AV strain was extracted and its physicochemical properties (structural, morphological, monosaccha-ride composition and molecular weight) were characterized. The EPS's in vitro biological activities and in vivo wound healing potential were also evaluated.Results: The obtained EPS was water-soluble and revealed an average molecular weight (Mw) of 202 kDa. Mannose and glucose with 97% and 3% molar percentages, respectively, constituted the EPS. In vitro antibacterial activity analysis of the extracted EPS exhibited antibacterial activity (>80%) against Escherichia coli, Staphylococcus aureus, and Staphylococcus epidermidis at a concentration of 2 mg/mL. The EPS showed cytocompatibility against the human fibroblast and macrophage cell lines and the ani-mal studies showed a dose-dependent wound healing capacity of the EPS with higher wound closure at 10 mg/mL compared to negative and positive control after 14 days.Conclusion: The EPS from P. terrestris PT22AV could serve as a promising source of biocompatible macro-molecules with potential for skin wound healing.
Keywords
Exopolysaccharide (EPS), BETA-GLUCAN RECOGNITION, ANTIOXIDANT ACTIVITIES, PHYSICOCHEMICAL CHARACTERIZATION, EXTRACELLULAR POLYSACCHARIDE, ANTIBACTERIAL, MACROPHAGES, EPS, BIOSYNTHESIS, CYTOTOXICITY, COMPLEMENT

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MLA
Hamidi, Masoud, et al. “Exopolysaccharide from the Yeast Papiliotrema Terrestris PT22AV for Skin Wound Healing.” JOURNAL OF ADVANCED RESEARCH, vol. 46, 2023, pp. 61–74, doi:10.1016/j.jare.2022.06.012.
APA
Hamidi, M., Okoro, O. V., Ianiri, G., Jafari, H., Rashidi, K., Ghasemi, S., … Shavandi, A. (2023). Exopolysaccharide from the yeast Papiliotrema terrestris PT22AV for skin wound healing. JOURNAL OF ADVANCED RESEARCH, 46, 61–74. https://doi.org/10.1016/j.jare.2022.06.012
Chicago author-date
Hamidi, Masoud, Oseweuba Valentine Okoro, Giuseppe Ianiri, Hafez Jafari, Khodabakhsh Rashidi, Saeed Ghasemi, Raffaello Castoria, et al. 2023. “Exopolysaccharide from the Yeast Papiliotrema Terrestris PT22AV for Skin Wound Healing.” JOURNAL OF ADVANCED RESEARCH 46: 61–74. https://doi.org/10.1016/j.jare.2022.06.012.
Chicago author-date (all authors)
Hamidi, Masoud, Oseweuba Valentine Okoro, Giuseppe Ianiri, Hafez Jafari, Khodabakhsh Rashidi, Saeed Ghasemi, Raffaello Castoria, Davide Palmieri, Cédric Delattre, Guillaume Pierre, Mahta Mirzaei, Lei Nie, Hadi Samadian, and Amin Shavandi. 2023. “Exopolysaccharide from the Yeast Papiliotrema Terrestris PT22AV for Skin Wound Healing.” JOURNAL OF ADVANCED RESEARCH 46: 61–74. doi:10.1016/j.jare.2022.06.012.
Vancouver
1.
Hamidi M, Okoro OV, Ianiri G, Jafari H, Rashidi K, Ghasemi S, et al. Exopolysaccharide from the yeast Papiliotrema terrestris PT22AV for skin wound healing. JOURNAL OF ADVANCED RESEARCH. 2023;46:61–74.
IEEE
[1]
M. Hamidi et al., “Exopolysaccharide from the yeast Papiliotrema terrestris PT22AV for skin wound healing,” JOURNAL OF ADVANCED RESEARCH, vol. 46, pp. 61–74, 2023.
@article{8766037,
  abstract     = {{Introduction: Exopolysaccharides (EPSs) are high-value functional biomaterials mainly produced by bac-teria and fungi, with nutraceutical, therapeutic and industrial potentials.Objectives: This study sought to characterize and assess the biological properties of the EPS produced by the yeast Papiliotrema terrestris PT22AV.Methods: After extracting the yeast's DNA and its molecular identification, the EPS from P. terrestris PT22AV strain was extracted and its physicochemical properties (structural, morphological, monosaccha-ride composition and molecular weight) were characterized. The EPS's in vitro biological activities and in vivo wound healing potential were also evaluated.Results: The obtained EPS was water-soluble and revealed an average molecular weight (Mw) of 202 kDa. Mannose and glucose with 97% and 3% molar percentages, respectively, constituted the EPS. In vitro antibacterial activity analysis of the extracted EPS exhibited antibacterial activity (>80%) against Escherichia coli, Staphylococcus aureus, and Staphylococcus epidermidis at a concentration of 2 mg/mL. The EPS showed cytocompatibility against the human fibroblast and macrophage cell lines and the ani-mal studies showed a dose-dependent wound healing capacity of the EPS with higher wound closure at 10 mg/mL compared to negative and positive control after 14 days.Conclusion: The EPS from P. terrestris PT22AV could serve as a promising source of biocompatible macro-molecules with potential for skin wound healing.}},
  author       = {{Hamidi, Masoud and Okoro, Oseweuba Valentine and Ianiri, Giuseppe and Jafari, Hafez and Rashidi, Khodabakhsh and Ghasemi, Saeed and Castoria, Raffaello and Palmieri, Davide and Delattre, Cédric and Pierre, Guillaume and Mirzaei, Mahta and Nie, Lei and Samadian, Hadi and Shavandi, Amin}},
  issn         = {{2090-1232}},
  journal      = {{JOURNAL OF ADVANCED RESEARCH}},
  keywords     = {{Exopolysaccharide (EPS),BETA-GLUCAN RECOGNITION,ANTIOXIDANT ACTIVITIES,PHYSICOCHEMICAL CHARACTERIZATION,EXTRACELLULAR POLYSACCHARIDE,ANTIBACTERIAL,MACROPHAGES,EPS,BIOSYNTHESIS,CYTOTOXICITY,COMPLEMENT}},
  language     = {{eng}},
  pages        = {{61--74}},
  title        = {{Exopolysaccharide from the yeast Papiliotrema terrestris PT22AV for skin wound healing}},
  url          = {{http://doi.org/10.1016/j.jare.2022.06.012}},
  volume       = {{46}},
  year         = {{2023}},
}
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