@article{8765915,
  abstract     = {{The targeted inhibition of effector cytokines such as interleukin 17 (IL-17) in psoriasis and IL-13 in atopic dermatitis offers impressive efficacy with a favorable side effect profile. In contrast, the downregulation of interferon gamma (IFN-gamma) in T helper (Th) 1-dominant skin disorders may lead to more adverse events, given the crucial role of IFN-gamma in antiviral and antitumoral immunity. Modulating Th17 and Th2 cell differentiation is performed by blocking IL-23 and IL-4, respectively, whereas anti-IL-12 antibodies are only moderately effective in downregulating Th1 lymphocyte differentiation. Therefore, a targeted approach of IFN-gamma-driven disorders remains challenging. Recent literature suggests that certain pathogenic Th17 cell subsets with Th1 characteristics, such as CD4(+)CD161(+)CCR6(+)CXCR3(+)IL-17(+)IFN-y(+) (Th17.1) and CD4(+)CD161(+)CCR6(+)CXCR3(+)IL-17(-)IFN-y(+) (exTh17), are important contributors in Th1-mediated autoimmunity. Differentiation to a Th17.1 or exTh17 profile results in the upregulation of IFN-y. Remarkably, these pathogenic Th17 cell subsets are resistant to glucocorticoid therapy and the dampening effect of regulatory T cells (Treg). The identification of Th17.1/exTh17 cells in auto-immune disorders may explain the frequent treatment failure of conventional immunosuppressants. In this review, we summarize the current evidence regarding the cellular plasticity of Th17 cells in inflammatory skin disorders. A deeper understanding of this phenomenon may lead to better insights into the pathogenesis of various skin diseases and the discovery of a potential new treatment target.}},
  articleno    = {{932265}},
  author       = {{Belpaire, Arno and van Geel, Nanja and Speeckaert, Reinhart}},
  editor       = {{Paradowska-Gorycka, Agnieszka}},
  issn         = {{1664-3224}},
  journal      = {{FRONTIERS IN IMMUNOLOGY}},
  keywords     = {{IFN and y,IL-17,Th17,Th17.1,inflammatory skin disease,plasticity,psoriasis,vitiligo,VERSUS-HOST-DISEASE,ATOPIC-DERMATITIS,T CELLS,TH17 CELLS,SARCOIDOSIS,PSORIASIS,DISTINCT,INTERLEUKIN-23,PLASTICITY,FEATURES}},
  language     = {{eng}},
  pages        = {{8}},
  title        = {{From IL-17 to IFN-γ in inflammatory skin disorders : is transdifferentiation a potential treatment target?}},
  url          = {{http://doi.org/10.3389/fimmu.2022.932265}},
  volume       = {{13}},
  year         = {{2022}},
}

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