@article{8765308,
  abstract     = {{Background

Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial compared two strategies of KRT initiation (accelerated versus standard) in critically ill patients with acute kidney injury and found neutral results for 90-day all-cause mortality. Probabilistic exploration of the trial endpoints may enable greater understanding of the trial findings. We aimed to perform a reanalysis using a Bayesian framework.
Methods

We performed a secondary analysis of all 2927 patients randomized in multi-national STARRT-AKI trial, performed at 168 centers in 15 countries. The primary endpoint, 90-day all-cause mortality, was evaluated using hierarchical Bayesian logistic regression. A spectrum of priors includes optimistic, neutral, and pessimistic priors, along with priors informed from earlier clinical trials. Secondary endpoints (KRT-free days and hospital-free days) were assessed using zero–one inflated beta regression.
Results

The posterior probability of benefit comparing an accelerated versus a standard KRT initiation strategy for the primary endpoint suggested no important difference, regardless of the prior used (absolute difference of 0.13% [95% credible interval [CrI] − 3.30%; 3.40%], − 0.39% [95% CrI − 3.46%; 3.00%], and 0.64% [95% CrI − 2.53%; 3.88%] for neutral, optimistic, and pessimistic priors, respectively). There was a very low probability that the effect size was equal or larger than a consensus-defined minimal clinically important difference. Patients allocated to the accelerated strategy had a lower number of KRT-free days (median absolute difference of − 3.55 days [95% CrI − 6.38; − 0.48]), with a probability that the accelerated strategy was associated with more KRT-free days of 0.008. Hospital-free days were similar between strategies, with the accelerated strategy having a median absolute difference of 0.48 more hospital-free days (95% CrI − 1.87; 2.72) compared with the standard strategy and the probability that the accelerated strategy had more hospital-free days was 0.66.
Conclusions

In a Bayesian reanalysis of the STARRT-AKI trial, we found very low probability that an accelerated strategy has clinically important benefits compared with the standard strategy. Patients receiving the accelerated strategy probably have fewer days alive and KRT-free. These findings do not support the adoption of an accelerated strategy of KRT initiation.}},
  articleno    = {{255}},
  author       = {{Zampieri, Fernando G. and da Costa, Bruno R. and Vaara, Suvi T. and Lamontagne, François and Rochwerg, Bram and Nichol, Alistair D. and McGuinness, Shay and McAuley, Danny F. and Ostermann, Marlies and Wald, Ron and Bagshaw, Sean M. and Bagshaw, Sean M. and Wald, Ron and Adhikari, Neill K. J. and Bellomo, Rinaldo and Dreyfuss, Didier and Du, Bin and Gallagher, Martin P. and Gaudry, Stéphane and Lamontagne, François and Joannidis, Michael and Liu, Kathleen D. and McAuley, Daniel F. and McGuinness, Shay P. and Nichol, Alistair D. and Ostermann, Marlies and Palevsky, Paul M. and Qiu, Haibo and Pettilä, Ville and Schneider, Antoine G. and Smith, Orla M. and Vaara, Suvi and Weir, Matthew and Bellomo, Rinaldo and Eastwood, Glenn M. and Peck, Leah and Young, Helen and Kruger, Peter and Laurie, Gordon and Saylor, Emma and Meyer, Jason and Venz, Ellen and Wetzig, Krista and French, Craig and McGain, Forbes and Mulder, John and Fennessy, Gerard and Koottayi, Sathyajith and Bates, Samantha and Towns, Miriam and Morgan, Rebecca and Tippett, Anna and Udy, Andrew and Mason, Chris and Licari, Elisa and Gantner, Dashiell and McClure, Jason and Nichol, Alistair and McCracken, Phoebe and Board, Jasmin and Martin, Emma and Vallance, Shirley and Young, Meredith and Vladic, Chelsey and McGloughlin, Steve and Gattas, David and Buhr, Heidi and Coles, Jennifer and Hutch, Debra and Wun, James and Cole, Louise and Whitehead, Christina and Lowrey, Julie and Masters, Kristy and Gresham, Rebecca and Campbell, Victoria and Gutierrez, David and Brailsford, Jane and Forbes, Loretta and Murray, Lauren and Maguire, Teena and NiChonghaile, Martina and Orford, Neil and Bone, Allison and Elderkin, Tania and Salerno, Tania and Chimunda, Tim and Fletcher, Jason and Broadfield, Emma and Porwal, Sanjay and Knott, Cameron and Boschert, Catherine and Smith, Julie and Richardson, Angus and Hill, Dianne and Duke, Graeme and Oziemski, Peter and Cegarra, Santiago and Chan, Peter and Welsh, Deborah and Hunter, Stephanie and Roodenburg, Owen and Dyett, John and Kokotsis, Nicos and Moser, Max and Yang, Yang and Padayachee, Laven and Vetro, Joseph and Gangopadhyay, Himangsu and Kaufman, Melissa and Ghosh, Angaj and Said, Simone and Patel, Alpesh and Bihari, Shailesh and Matheson, Elisha and Jin, Xia and Shrestha, Tapaswi and Schwartz, Kate and Gallagher, Martin P. and Cross, Rosalba and Cheung, Winston and Wong, Helen and Kol, Mark and Shah, Asim and Wang, Amanda Y. and Endre, Zoltan and Bradford, Celia and Janin, Pierre and Finfer, Simon and Diel, Naomi and Gatward, Jonathan and Hammond, Naomi and Delaney, Anthony and Bass, Frances and Yarad, Elizabeth and Buscher, Hergen and Reynolds, Claire and Baker, Nerilee and Joannidis, Michael and Bellmann, Romuald and Peer, Andreas and Hasslacher, Julia and Koglberger, Paul and Klein, Sebastian and Zotter, Klemens and Brandtner, Anna and Finkenstedt, Armin and Ditlbacher, Adelheid and Hartig, Frank and Fries, Dietmar and Bachler, Mirjam and Schenk, Bettina and Wagner, Martin and Eller, Philipp and Staudinger, Thomas and Tiller, Esther and Schellongowski, Peter and Bojic, Andja and Hoste, Eric and Bracke, Stephanie and De Crop, Luc and Vermeiren, Daisy and Thome, Fernando and Chiella, Bianca and Fendt, Lucia and Antunes, Veronica and Lafrance, Jean-Philippe and Lamontagne, François and D’Aragon, Frédérick and St-Arnaud, Charles and Mayette, Michael and Carbonnaeu, Élaine and Marchand, Joannie and Masse, Marie-Hélène and Ladouceur, Marilène and Turgeon, Alexis F. and Lauzier, François and Bellemare, David and Francoeur, Charles Langis and LeBlanc, Guillaume and Guilbault, Gabrielle and Grenier, Stéphanie and Cloutier, Eve and Boivin, Annick and Delisle-Thibault, Charles and Giannakouros, Panagiota and Costerousse, Olivier and Cailhier, Jean-François and Carrier, François-Martin and Ghamraoui, Ali and Lebrasseur, Martine and Benettaib, Fatna and Salamé, Maya and Boumahni, Dounia and Sia, Ying Tung and Naud, Jean-François and Roy, Isabelle and Stelfox, Henry T. and Ruddell, Stacey and Manns, Braden J. and Duggan, Shelley and Carney, Dominic and Barchard, Jennifer and Whitlock, Richard P. and Belley-Cote, Emilie and Savija, Nevena and Sabev, Alexandra and Campbell, Troy and Creary, Thais and Devereaux, Kelson and Brodutch, Shira and Rigatto, Claudio and Paunovic, Bojan and Mooney, Owen and Glybina, Anna and Harasemiw, Oksana and Di Nella, Michelle and Harmon, John and Mehta, Navdeep and Lakatos, Louis and Haslam, Nicole and Lellouche, Francois and Simon, Mathieu and Tung, Ying and Lizotte, Patricia and Bourchard, Pierre-Alexandre and Rochwerg, Bram and Karachi, Tim and Millen, Tina and Muscedere, John and Maslove, David and Gordon Boyd, J. and Sibley, Stephanie and Drover, John and Hunt, Miranda and Georgescu, Ilinca and Wax, Randy and Lenga, Ilan and Sridhar, Kavita and Steele, Andrew and Fusco, Kelly and Ghate, Taneera and Tolibas, Michael and Robinson, Holly and Weir, Matthew A. and Taneja, Ravi and Ball, Ian M. and Garg, Amit and Campbell, Eileen and Ovsenek, Athena and Bagshaw, Sean M. and van Diepen, Sean and Baig, Nadia and Magder, Sheldon and Yao, Han and Alam, Ahsan and Campisi, Josie and MacIntyre, Erika and Rokosh, Ella and Scherr, Kimberly and Lapinsky, Stephen and Mehta, Sangeeta and Shah, Sumesh and Niven, Daniel J. and Stelfox, Henry T. and Ruddell, Stacey and Russell, Michael and Jim, Kym and Brown, Gillian and Oxtoby, Kerry and Hall, Adam and Benoit, Luc and Sokolowski, Colleen and Prasad, Bhanu and Rao, Jag and Giebel, Shelley and Kutsogiannis, Demetrios J. and Thompson, Patricia and Thompson, Tayne and Cirone, Robert and Kavikondala, Kanthi and Soth, Mark and Clarke, France and Takaoka, Alyson and Wald, Ron and Mazer, David and Burns, Karen and Friedrich, Jan and Klein, David and Sandhu, Gyan and Santos, Marlene and Khalid, Imrana and Hodder, Jennifer and Dodek, Peter and Ayas, Najib and Alcuaz, Victoria and Suen, Gabriel and Rewa, Oleksa and Singh, Gurmeet and Norris, Sean and Gibson, Neil and Arias, Castro and Shami, Aysha and Pelletier, Celine and Adhikari, Neill K. J. and Zahirieh, Alireza and Amaral, Andre and Marinoff, Nicole and Kaur, Navjot and Perez, Adic and Wang, Jane and Haljan, Gregory and Condin, Christopher and McIntyre, Lauralyn and Gomes, Brigette and Porteous, Rebecca and Watpool, Irene and Hiremath, Swapnil and Clark, Edward and Herridge, Margaret S. and Backhouse, Felicity and Elizabeth Wilcox, M. and Walczak, Karolina and Ki, Vincent and Sharman, Asheer and Romano, Martin and Bagshaw, Sean M. and Noel Gibney, R. T. and Romanovsky, Adam S. and Rewa, Oleksa and McCoshen, Lorena and Baig, Nadia and Wood, Gordon and Ovakim, Daniel and Auld, Fiona and Carney, Gayle and Duan, Meili and Ji, Xiaojun and Guo, Dongchen and Qi, Zhili and Lin, Jin and Zhang, Meng and Dong, Lei and Liu, Jingfeng and Liu, Pei and Zhi, Deyuan and Bai, Guoqiang and Qiu, Yu and Yang, Ziqi and Bai, Jing and Liu, Zhuang and Zhuang, Haizhou and Wang, Haiman and Li, Jian and Zhao, Mengya and Zhou, Xiao and Shi, Xianqing and Ye, Baning and Liu, Manli and Wu, Jing and Fu, Yongjian and Long, Dali and Pan, Yu and Wang, Jinlong and Mei, Huaxian and Zhang, Songsong and Wen, Mingxiang and Yang, Enyu and Mu, Sijie and Li, Jianquan and Hu, Tingting and Qin, Bingyu and Li, Min and Wang, Cunzhen and Dong, Xin and Wang, Kaiwu and Wang, Haibo and Yang, Jianxu and Du, Bin and Wang, Chuanyao and Wang, Dongxin and Li, Nan and Yu, Zhui and Xu, Song and Yao, Lan and Hou, Guo and Liu, Zhou and Lu, Liping and Lian, Yingtao and Wang, Chunting and Zhang, Jichen and Ding, Ruiqi and Qi, Guoqing and Wang, Qizhi and Wang, Peng and Meng, Zhaoli and Chen, Man and Hu, Xiaobo and He, Xiandi and Zhao, Shibing and Hang, Lele and Li, Rui and Qin, Suhui and Lu, Kun and Dun, Shijuan and Liu, Cheng and Zhou, Qi and Chen, Zhenzhen and Mei, Jing and Zhang, Minwei and Xu, Hao and Lin, Jincan and Shi, Qindong and Fu, Lijuan and Zeng, Qinjing and Ma, Hongye and Yan, Jinqi and Gao, Lan and Liu, Hongjuan and Zhang, Lei and Li, Hao and He, Xiaona and Fan, Jingqun and Guo, Litao and Liu, Yu and Wang, Xue and Sun, Jingjing and Liu, Zhongmin and Yang, Juan and Ding, Lili and Sheng, Lulu and Liu, Xingang and Yan, Jie and Wang, Quihui and Wang, Yifeng and Zhao, Dan and Zhao, Shuangping and Hu, Chenghuan and Li, Jing and Deng, Fuxing and Qui, Haibo and Yang, Yi and Mo, Min and Pan, Chun and Wu, Changde and Huang, Yingzi and Huang, Lili and Liu, Airan and Pettilä, Ville and Vaara, Suvi T. and Korhonen, Anna-Maija and Törnblom, Sanna and Sutinen, Sari and Pettilä, Leena and Heinonen, Jonna and Lappi, Eliria and Suhonen, Taria and Karlsson, Sari and Hoppu, Sanna and Jalkanen, Ville and Kuitunen, Anne and Levoranta, Markus and Långsjö, Jaakko and Ristimäki, Sanna and Malila, Kaisa and Wootten, Anna and Varila, Simo and Järvisalo, Mikko J. and Inkinen, Outi and Kentala, Satu and Leivo, Keijo and Haltia, Paivi and Dreyfuss, Didier and Ricard, Jean-Damien and Messika, Jonathan and Tiagarajah, Abirami and Emery, Malo and Dechanet, Aline and Gernez, Coralie and Roux, Damien and Martin-Lefevre, Laurent and Fiancette, Maud and Vinatier, Isabelle and Lacherade, Jean Claude and Colin, Gwenhaël and Lebert, Christine and Azais, Marie-Ange and Yehia, Aihem and Pouplet, Caroline and Lagarrigue, Matthieu Henry- and Seguin, Amélie and Crosby, Laura and Maizel, Julien and Titeca-Beauport, Dimitri and Combes, Alain and Nieszkowska, Ania and Masi, Paul and Demoule, Alexandre and Mayaux, Julien and Dres, Martin and Morawiec, Elise and Decalvele, Maxens and Demiri, Suela and Faure, Morgane and Marios, Clémence and Mallet, Maxime and Ordon, Marie Amélie and Morizot, Laura and Cantien, Marie and Pousset, François and Gaudry, Stéphane and Poirson, Florent and Cohen, Yves and Argaud, Laurent and Cour, Martin and Bitker, Laurent and Simon, Marie and Hernu, Romain and Baudry, Thomas and De La Salle, Sylvie and Robine, Adrien and Sedillot, Nicholas and Tchenio, Xavier and Bouisse, Camille and Roux, Sylvie and Barbar, Saber Davide and Trusson, Rémi and Tamion, Fabienne and Grangé, Steven and Carpentier, Dorothée and Chevrel, Guillaume and Ensenyat-Martin, Luis and Marque, Sophie and Quenot, Jean-Pierre and Andreu, Pascal and Dargent, Auguste and Large, Audrey and Chudeau, Nicolas and Landais, Mickael and Derrien, Benoit and Callahan, Jean Christophe and Guitton, Christophe and Le Moal, Charlène and Robert, Alain and Asehnoune, Karim and Cinotti, Raphaël and Grillot, Nicolas and Demeure, Dominique and Vinsonneau, Christophe and Rahmani, Imen and Marzouk, Mehdi and Dekeyser, Thibault and Sejourne, Caroline and Verlay, Mélanie and Thevenin, Fabienne and Delecolle, Lucie and Thevenin, Didier and Souweine, Bertrand and Coupez, Elisabeth and Adda, Mireille and Eraldi, Jean-Pierre and Marchalot, Antoine and De Prost, Nicolas and Dessap, Armand Mekontso and Razazi, Keyvan and Meziani, Ferhat and Boisrame-Helms, Julie and Clere-Jehl, Raphael and Delabranche, Xavier and Kummerlen, Christine and Merdji, Hamid and Monnier, Alexandra and Rabouel, Yannick and Rahmani, Hassene and Allam, Hayat and Chenaf, Samir and Franja, Vincenta and Pons, Bertrand and Carles, Michel and Martino, Frédéric and Richard, Régine and Zuber, Benjamin and Lacave, Guillaume and Lakhal, Karim and Rozec, Bertrand and Van, Hoa Dang and Boulet, Éric and Fadel, Fouad and Cleophax, Cedric and Dufour, Nicolas and Grant, Caroline and Thuong, Marie and Reignier, Jean and Canet, Emmanuel and Nicolet, Laurent and Boulain, Thierry and Nay, Mai-Anh and Benzekri, Dalila and Barbier, François and Bretagnol, Anne and Kamel, Toufik and Mathonnet, Armelle and Muller, Grégoire and Skarzynski, Marie and Rossi, Julie and Pradet, Amandine and Dos Santos, Sandra and Guery, Aurore and Muller, Lucie and Felix, Luis and Bohé, Julien and Thiéry, Guillaume and Aissaoui, Nadia and Vimpere, Damien and Commeureuc, Morgane and Diehl, Jean-Luc and Guerot, Emmanuel and Liangos, Orfeas and Wittig, Monika and Zarbock, Alexander and Küllmar, Mira and van Waegeningh, Thomas and Rosenow, Nadine and Nichol, Alistair D. and Brickell, Kathy and Doran, Peter and Murray, Patrick T. and Landoni, Giovanni and Lembo, Rosalba and Zangrillo, Alberto and Monti, Giacomo and Tozzi, Margherita and Marzaroli, Matteo and Lombardi, Gaetano and Paternoster, Gianluca and Vitiello, Michelangelo and McGuinness, Shay and Parke, Rachael and Butler, Magdalena and Gilder, Eileen and Cowdrey, Keri-Anne and Wallace, Samantha and Hallion, Jane and Woolett, Melissa and Neal, Philippa and Duffy, Karina and Long, Stephanie and McArthur, Colin and Simmonds, Catherine and Chen, Yan and McConnochie, Rachael and Newby, Lynette and Knight, David and Henderson, Seton and Mehrtens, Jan and Morgan, Stacey and Morris, Anna and Vander Hayden, Kymbalee and Burke, Tara and Bailey, Matthew and Freebairn, Ross and Chadwick, Lesley and Park, Penelope and Rolls, Christine and Thomas, Liz and Buehner, Ulrike and Williams, Erin and Albrett, Jonathan and Kirkham, Simon and Jackson, Carolyn and Browne, Troy and Goodson, Jennifer and Jackson, David and Houghton, James and Callender, Owen and Higson, Vicki and Keet, Owen and Dominy, Clive and Young, Paul and Hunt, Anna and Judd, Harriet and Lawrence, Cassie and Olatunji, Shaanti and Robertson, Yvonne and Latimer-Bell, Charlotte and Hendry, Deborah and Mckay-Vucago, Agnes and Beehre, Nina and Lesona, Eden and Navarra, Leanlove and Robinson, Chelsea and Jang, Ryan and Junge, Andrea and Lambert, Bridget and Schneider, Antoine G. and Thibault, Michel and Eckert, Philippe and Kissling, Sébastien and Polychronopoulos, Erietta and Poli, Elettra and Altarelli, Marco and Schnorf, Madeleine and Mallaird, Samia Abed and Heidegger, Claudia and Perret, Aurelie and Montillier, Philippe and Sangla, Frederic and Neils, Seigenthaller and De Watteville, Aude and Phull, Mandeep-Kaur and George, Aparna and Hussain, Nauman and Pogreban, Tatiana and Lobaz, Steve and Daniels, Alison and Cunningham, Mishell and Kerr, Deborah and Nicholson, Alice and Shanmugasundaram, Pradeep and Abrams, Judith and Manso, Katarina and Hambrook, Geraldine and McKerrow, Elizabeth and Salva, Juvy and Foulkes, Stephen and Wise, Matthew and Morgan, Matt and Brooks, Jenny and Cole, Jade and Davies, Tracy Michelle and Hill, Helen and Thomas, Emma and Vizcaychipi, Marcela and Baharlo, Behrad and Carungcong, Jaime and Costa, Patricia and Martins, Laura and Kapoor, Ritoo and Hazelton, Tracy and Moon, Angela and Musselwhite, Janine and Shelley, Ben and McCall, Philip and Ostermann, Marlies and Arbane, Gill and Bociek, Aneta and Marotti, Martina and Lim, Rosario and Campos, Sara and Novellas, Neus Grau and Cennamo, Armando and Slack, Andrew and Wyncoll, Duncan and Camporota, Luigi and Sparkes, Simon and Tilley, Rosalinde and Rattray, Austin and Moreland, Gayle and Duffy, Jane and McGonigal, Elizabeth and Hopkins, Philip and Finney, Clare and Smith, John and Noble, Harriet and Watson, Hayley and Harris, Claire-Louise and Clarey, Emma and Corcoran, Eleanor and Beck, James and Howcroft, Clare and Youngs, Nora and Wilby, Elizabeth and Ogg, Bethan and Wolverson, Adam and Lee, Sandra and Butler, Susie and Okubanjo, Maryanne and Hindle, Julia and Welters, Ingeborg and Williams, Karen and Johnson, Emily and Patrick-Heselton, Julie and Shaw, David and Waugh, Victoria and Stewart, Richard and Mwaura, Esther and Wren, Lynn and Mew, Louise and Sutherland, Sara-Beth and Adderley, Jane and Ruddy, Jim and Harkins, Margaret and Kaye, Callum and Scott, Teresa and Mitchell, Wendy and Anderson, Felicity and Willox, Fiona and Jagannathan, Vijay and Clark, Michele and Purv, Sarah and Sharman, Andrew and Meredith, Megan and Ryan, Lucy and Conner, Louise and Peters, Cecilia and Harvey, Dan and Roshdy, Ashraf and Collins, Amy and Sim, Malcolm and Henderson, Steven and Chee, Nigel and Pitts, Sally and Bowman, Katie and Dilawershah, Maria and Vamplew, Luke and Howe, Elizabeth and Rogers, Paula and Hernandez, Clara and Prendergast, Clara and Benton, Jane and Rosenberg, Alex and Forni, Lui G. and Grant, Alice and Carvelli, Paula and Raithatha, Ajay and Bird, Sarah and Richardson, Max and Needham, Matthew and Hirst, Claire and Ball, Jonathan and Leaver, Susannah and Howlett, Luisa and Delgado, Carlos Castro and Farnell-Ward, Sarah and Farrah, Helen and Gray, Geraldine and Joseph, Gipsy and Robinson, Francesca and Tridente, Ascanio and Harrop, Clare and Shuker, Karen and McLaughlan, Derek and Ramsey, Judith and Meehan, Sharon and Rose, Bernd Oliver and Reece-Anthony, Rosie and Gurung, Babita and Whitehouse, Tony and Snelson, Catherine and Veenith, Tonny and Johnston, Andy and Cooper, Lauren and Carrera, Ron and Ellis, Karen and Fellows, Emma and Harkett, Samanth and Bergin, Colin and Spruce, Elaine and Despy, Liesl and Goundry, Stephanie and Dooley, Natalie and Mason, Tracy and Clark, Amy and Dignam, Gemma and Ward, Geraldine and Attwood, Ben and Parsons, Penny and Mason, Sophie and Margarson, Michael and Lord, Jenny and McGlone, Philip and Hodgson, Luke E. and Chadbourn, Indra and Gomez, Raquel and Margalef, Jordi and Pretorius, Rinus and Hamshere, Alexandra and Carter, Joseph and Cahill, Hazel and Grainger, Lia and Howard, Kate and Forshaw, Greg and Guy, Zoe and Kashani, Kianoush B. and Albright, Robert C. and Amsbaugh, Amy and Stoltenberg, Anita and Niven, Alexander S. and Lynch, Matthew and O’Mara, AnnMarie and Naeem, Syed and Sharif, Sairah and Goulart, Joyce McKenney and Lynch, Matthew and O’Mara, AnnMarie and Naeem, Syed and Sharif, Sairah and Goulart, Joyce McKenney and Tolwani, Ashita and Lyas, Claretha and Latta, Laura and Bihorac, Azra and Hashemighouchani, Haleh and Efron, Philip and Ruppert, Matthew and Cupka, Julie and Kiley, Sean and Carson, Joshua and White, Peggy and Omalay, George and Brown, Sherry and Velez, Laura and Marceron, Alina and Neyra, Javier A. and Aycinena, Juan Carlos and Elias, Madona and Ortiz-Soriano, Victor M. and Hauschild, Caroline and Dorfman, Robert and Investigators, STARRT-AKI}},
  issn         = {{1364-8535}},
  journal      = {{CRITICAL CARE}},
  keywords     = {{Critical Care and Intensive Care Medicine,Trial,Randomized,Dialysis,Mortality,Acute kidney injury,Kidney-replacement therapy,Bayesian}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{10}},
  title        = {{A Bayesian reanalysis of the standard versus accelerated initiation of renal-replacement therapy in acute kidney injury (STARRT-AKI) trial}},
  url          = {{http://doi.org/10.1186/s13054-022-04120-y}},
  volume       = {{26}},
  year         = {{2022}},
}

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