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In vitro models of gut digestion across childhood : current developments, challenges and future trends

Elora Fournier, Charlene Roussel, Alessandra Dominicis, Delphine Ley, Marie-Agnes Peyron, Valerie Collado, Muriel Mercier-Bonin, Christophe Lacroix, Monique Alric, Tom Van de Wiele (UGent) , et al.
(2022) BIOTECHNOLOGY ADVANCES. 54.
Author
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Abstract
The human digestion is a multi-step and multi-compartment process essential for human health, at the heart of many issues raised by academics, the medical world and industrials from the food, nutrition and pharma fields. In the first years of life, major dietary changes occur and are concomitant with an evolution of the whole child digestive tract anatomy and physiology, including colonization of gut microbiota. All these phenomena are influenced by child exposure to environmental compounds, such as drugs (especially antibiotics) and food pollutants, but also childhood infections. Due to obvious ethical, regulatory and technical limitations, in vivo approaches in animal and human are more and more restricted to favor complementary in vitro approaches. This review summarizes current knowledge on the evolution of child gut physiology from birth to 3 years old regarding physicochemical, mechanical and microbial parameters. Then, all the available in vitro models of the child digestive tract are described, ranging from the simplest static mono-compartmental systems to the most sophisticated dynamic and multi-compartmental models, and mimicking from the oral phase to the colon compartment. Lastly, we detail the main applications of child gut models in nutritional, pharmaceutical and microbiological studies and discuss the limitations and challenges facing this field of research.
Keywords
Child, Digestion, Gut physiology evolution, Gut microbiota, In vitro gut models, Nutrition, Pharmacy, Microbiology, Toxicology, COLONIC FERMENTATION MODEL, CHAIN FATTY-ACIDS, HUMAN-FETAL SMALL, WHOLE UNSTIMULATED SALIVA, COMPUTER-CONTROLLED MODEL, INTESTINAL MICROBIOTA, GASTROINTESTINAL-TRACT, HUMAN-MILK, 1ST YEAR, PROBIOTIC STRAINS

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MLA
Fournier, Elora, et al. “In Vitro Models of Gut Digestion across Childhood : Current Developments, Challenges and Future Trends.” BIOTECHNOLOGY ADVANCES, vol. 54, 2022, doi:10.1016/j.biotechadv.2021.107796.
APA
Fournier, E., Roussel, C., Dominicis, A., Ley, D., Peyron, M.-A., Collado, V., … Blanquet-Diot, S. (2022). In vitro models of gut digestion across childhood : current developments, challenges and future trends. BIOTECHNOLOGY ADVANCES, 54. https://doi.org/10.1016/j.biotechadv.2021.107796
Chicago author-date
Fournier, Elora, Charlene Roussel, Alessandra Dominicis, Delphine Ley, Marie-Agnes Peyron, Valerie Collado, Muriel Mercier-Bonin, et al. 2022. “In Vitro Models of Gut Digestion across Childhood : Current Developments, Challenges and Future Trends.” BIOTECHNOLOGY ADVANCES 54. https://doi.org/10.1016/j.biotechadv.2021.107796.
Chicago author-date (all authors)
Fournier, Elora, Charlene Roussel, Alessandra Dominicis, Delphine Ley, Marie-Agnes Peyron, Valerie Collado, Muriel Mercier-Bonin, Christophe Lacroix, Monique Alric, Tom Van de Wiele, Christophe Chassard, Lucie Etienne-Mesmin, and Stephanie Blanquet-Diot. 2022. “In Vitro Models of Gut Digestion across Childhood : Current Developments, Challenges and Future Trends.” BIOTECHNOLOGY ADVANCES 54. doi:10.1016/j.biotechadv.2021.107796.
Vancouver
1.
Fournier E, Roussel C, Dominicis A, Ley D, Peyron M-A, Collado V, et al. In vitro models of gut digestion across childhood : current developments, challenges and future trends. BIOTECHNOLOGY ADVANCES. 2022;54.
IEEE
[1]
E. Fournier et al., “In vitro models of gut digestion across childhood : current developments, challenges and future trends,” BIOTECHNOLOGY ADVANCES, vol. 54, 2022.
@article{8764001,
  abstract     = {{The human digestion is a multi-step and multi-compartment process essential for human health, at the heart of many issues raised by academics, the medical world and industrials from the food, nutrition and pharma fields. In the first years of life, major dietary changes occur and are concomitant with an evolution of the whole child digestive tract anatomy and physiology, including colonization of gut microbiota. All these phenomena are influenced by child exposure to environmental compounds, such as drugs (especially antibiotics) and food pollutants, but also childhood infections. Due to obvious ethical, regulatory and technical limitations, in vivo approaches in animal and human are more and more restricted to favor complementary in vitro approaches. This review summarizes current knowledge on the evolution of child gut physiology from birth to 3 years old regarding physicochemical, mechanical and microbial parameters. Then, all the available in vitro models of the child digestive tract are described, ranging from the simplest static mono-compartmental systems to the most sophisticated dynamic and multi-compartmental models, and mimicking from the oral phase to the colon compartment. Lastly, we detail the main applications of child gut models in nutritional, pharmaceutical and microbiological studies and discuss the limitations and challenges facing this field of research.}},
  articleno    = {{107796}},
  author       = {{Fournier, Elora and Roussel, Charlene and Dominicis, Alessandra and Ley, Delphine and Peyron, Marie-Agnes and Collado, Valerie and Mercier-Bonin, Muriel and Lacroix, Christophe and Alric, Monique and Van de Wiele, Tom and Chassard, Christophe and Etienne-Mesmin, Lucie and Blanquet-Diot, Stephanie}},
  issn         = {{0734-9750}},
  journal      = {{BIOTECHNOLOGY ADVANCES}},
  keywords     = {{Child,Digestion,Gut physiology evolution,Gut microbiota,In vitro gut models,Nutrition,Pharmacy,Microbiology,Toxicology,COLONIC FERMENTATION MODEL,CHAIN FATTY-ACIDS,HUMAN-FETAL SMALL,WHOLE UNSTIMULATED SALIVA,COMPUTER-CONTROLLED MODEL,INTESTINAL MICROBIOTA,GASTROINTESTINAL-TRACT,HUMAN-MILK,1ST YEAR,PROBIOTIC STRAINS}},
  language     = {{eng}},
  pages        = {{27}},
  title        = {{In vitro models of gut digestion across childhood : current developments, challenges and future trends}},
  url          = {{http://doi.org/10.1016/j.biotechadv.2021.107796}},
  volume       = {{54}},
  year         = {{2022}},
}
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