Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer
- Author
- Teodora-Eugenia Oltean, Lien Lippens (UGent) , Kelly Lemeire (UGent) , Caroline De Tender (UGent) , Marnik Vuylsteke, Hannelore Denys (UGent) , Katrien Vandecasteele (UGent) , Peter Vandenabeele (UGent) and Sandy Adjemian Catani (UGent)
- Organization
- Project
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- Role of dead cell clearance in resolution of inflammation and tissue regeneration
- MOlecular mechanisms of cellular DEath and Life decisions in Inflammation, Degeneration and Infection
- Cell Death Regulation and Role in Infection and Inflammatory Diseases
- Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy
- Role and mechanism of RIPK1 during immunogenic cell death by necroptosis
- Unraveling the in vivo role of RIPK1: Physiological and pathological consequences of kinase-dependent and kinase-independent functions
- Factors that determine RIPK1-dependent necroptosis
- Mechanisms of ferroptosis mediated immunoregulation
- Cell death activity regulation in inflammation and cancer
- Response of the strawberry rhizosphere microbiome to chitin and biochar in function of plant health: expanding towards metatranscriptomics and DNA-SIP
- Investigating the role of ferroptosis in acute liver injury and multiple sclerosis with newly developed chemical tool compounds
- Thymic reprogramming: The role of Death Receptor 3 (DR3)
- Improving cancer therapy by modulating cell death and the microbiome in the gut
- Abstract
- Irradiation induces distinct cellular responses such as apoptosis, necroptosis, iron-dependent cell death (a feature of ferroptosis), senescence, and mitotic catastrophe. Several of these outcomes are immunostimulatory and may represent a potential for immunogenic type of cell death (ICD) induced by radiotherapy triggering abscopal effects. The purpose of this study is to determine whether intra-tumoral ICD markers can serve as biomarkers for the prediction of patient's outcomes defined as the metastasis status and survival over a 5-year period. Thirty-eight patients with locally advanced cervical cancer, treated with neoadjuvant chemoradiotherapy using cisplatin were included in this study. Pre-treatment tumor biopsy and post-treatment hysterectomy samples were stained for cell death markers and danger associated molecular patterns (DAMPs): cleaved caspase-3 (apoptosis), phosphorylated mixed lineage kinase domain like pseudokinase (pMLKL; necroptosis), glutathione peroxidase 4 (GPX4; ferroptosis) and 4-hydroxy-2-noneal (4-HNE; ferroptosis), high mobility group box 1 (HMGB1) and calreticulin. Although these markers could not predict the patient's outcome in terms of relapse or survival, many significantly correlated with immune cell infiltration. For instance, inducing ferroptosis post-treatment seems to negatively impact immune cell recruitment. Measuring ICD markers could reflect the impact of treatment on the tumor microenvironment with regard to immune cell recruitment and infiltration. One Sentence SummaryCell death readouts during neoadjuvant chemoradiation in cervical cancer
- Keywords
- Cancer Research, Oncology, cervical cancer, biomarkers, immunogenic cell death, cell death, tumor infiltrating leucocytes, MODULATED ARC THERAPY, NECROPTOSIS, CHEMORADIOTHERAPY, OVEREXPRESSION, RADIOTHERAPY, CARCINOMA, OUTCOMES, DAMAGE, MLKL
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2022 Oltean asssociation of cell death markers with tumor immune cell infiltrates after chemo-radation in cervical cancer.pdf
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8762757
- MLA
- Oltean, Teodora-Eugenia, et al. “Association of Cell Death Markers with Tumor Immune Cell Infiltrates after Chemo-Radiation in Cervical Cancer.” FRONTIERS IN ONCOLOGY, vol. 12, 2022, doi:10.3389/fonc.2022.892813.
- APA
- Oltean, T.-E., Lippens, L., Lemeire, K., De Tender, C., Vuylsteke, M., Denys, H., … Adjemian Catani, S. (2022). Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer. FRONTIERS IN ONCOLOGY, 12. https://doi.org/10.3389/fonc.2022.892813
- Chicago author-date
- Oltean, Teodora-Eugenia, Lien Lippens, Kelly Lemeire, Caroline De Tender, Marnik Vuylsteke, Hannelore Denys, Katrien Vandecasteele, Peter Vandenabeele, and Sandy Adjemian Catani. 2022. “Association of Cell Death Markers with Tumor Immune Cell Infiltrates after Chemo-Radiation in Cervical Cancer.” FRONTIERS IN ONCOLOGY 12. https://doi.org/10.3389/fonc.2022.892813.
- Chicago author-date (all authors)
- Oltean, Teodora-Eugenia, Lien Lippens, Kelly Lemeire, Caroline De Tender, Marnik Vuylsteke, Hannelore Denys, Katrien Vandecasteele, Peter Vandenabeele, and Sandy Adjemian Catani. 2022. “Association of Cell Death Markers with Tumor Immune Cell Infiltrates after Chemo-Radiation in Cervical Cancer.” FRONTIERS IN ONCOLOGY 12. doi:10.3389/fonc.2022.892813.
- Vancouver
- 1.Oltean T-E, Lippens L, Lemeire K, De Tender C, Vuylsteke M, Denys H, et al. Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer. FRONTIERS IN ONCOLOGY. 2022;12.
- IEEE
- [1]T.-E. Oltean et al., “Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer,” FRONTIERS IN ONCOLOGY, vol. 12, 2022.
@article{8762757,
abstract = {{Irradiation induces distinct cellular responses such as apoptosis, necroptosis, iron-dependent cell death (a feature of ferroptosis), senescence, and mitotic catastrophe. Several of these outcomes are immunostimulatory and may represent a potential for immunogenic type of cell death (ICD) induced by radiotherapy triggering abscopal effects. The purpose of this study is to determine whether intra-tumoral ICD markers can serve as biomarkers for the prediction of patient's outcomes defined as the metastasis status and survival over a 5-year period. Thirty-eight patients with locally advanced cervical cancer, treated with neoadjuvant chemoradiotherapy using cisplatin were included in this study. Pre-treatment tumor biopsy and post-treatment hysterectomy samples were stained for cell death markers and danger associated molecular patterns (DAMPs): cleaved caspase-3 (apoptosis), phosphorylated mixed lineage kinase domain like pseudokinase (pMLKL; necroptosis), glutathione peroxidase 4 (GPX4; ferroptosis) and 4-hydroxy-2-noneal (4-HNE; ferroptosis), high mobility group box 1 (HMGB1) and calreticulin. Although these markers could not predict the patient's outcome in terms of relapse or survival, many significantly correlated with immune cell infiltration. For instance, inducing ferroptosis post-treatment seems to negatively impact immune cell recruitment. Measuring ICD markers could reflect the impact of treatment on the tumor microenvironment with regard to immune cell recruitment and infiltration. One Sentence SummaryCell death readouts during neoadjuvant chemoradiation in cervical cancer}},
articleno = {{892813}},
author = {{Oltean, Teodora-Eugenia and Lippens, Lien and Lemeire, Kelly and De Tender, Caroline and Vuylsteke, Marnik and Denys, Hannelore and Vandecasteele, Katrien and Vandenabeele, Peter and Adjemian Catani, Sandy}},
issn = {{2234-943X}},
journal = {{FRONTIERS IN ONCOLOGY}},
keywords = {{Cancer Research,Oncology,cervical cancer,biomarkers,immunogenic cell death,cell death,tumor infiltrating leucocytes,MODULATED ARC THERAPY,NECROPTOSIS,CHEMORADIOTHERAPY,OVEREXPRESSION,RADIOTHERAPY,CARCINOMA,OUTCOMES,DAMAGE,MLKL}},
language = {{eng}},
pages = {{12}},
title = {{Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer}},
url = {{http://doi.org/10.3389/fonc.2022.892813}},
volume = {{12}},
year = {{2022}},
}
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