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Recent advances in the use of focused ultrasound as a treatment for epilepsy

Emma Lescrauwaet (UGent) , Kristl Vonck (UGent) , Mathieu Sprengers (UGent) , Robrecht Raedt (UGent) , Deborah Klooster (UGent) , Evelien Carrette (UGent) and Paul Boon (UGent)
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Abstract
Epilepsy affects about 1% of the population. Approximately one third of patients with epilepsy are drug-resistant (DRE). Resective surgery is an effective treatment for DRE, yet invasive, and not all DRE patients are suitable resective surgery candidates. Focused ultrasound, a novel non-invasive neurointerventional method is currently under investigation as a treatment alternative for DRE. By emitting one or more ultrasound waves, FUS can target structures in the brain at millimeter resolution. High intensity focused ultrasound (HIFU) leads to ablation of tissue and could therefore serve as a non-invasive alternative for resective surgery. It is currently under investigation in clinical trials following the approval of HIFU for essential tremor and Parkinson’s disease. Low intensity focused ultrasound (LIFU) can modulate neuronal activity and could be used to lower cortical neuronal hyper-excitability in epilepsy patients in a non-invasive manner. The seizure-suppressive effect of LIFU has been studied in several preclinical trials, showing promising results. Further investigations are required to demonstrate translation of preclinical results to human subjects.
Keywords
General Neuroscience, high intensity focused ultrasound, low intensity focused ultrasound, refractory epilepsy, non-invasive, neuromodulation

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MLA
Lescrauwaet, Emma, et al. “Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy.” FRONTIERS IN NEUROSCIENCE, vol. 16, 2022, doi:10.3389/fnins.2022.886584.
APA
Lescrauwaet, E., Vonck, K., Sprengers, M., Raedt, R., Klooster, D., Carrette, E., & Boon, P. (2022). Recent advances in the use of focused ultrasound as a treatment for epilepsy. FRONTIERS IN NEUROSCIENCE, 16. https://doi.org/10.3389/fnins.2022.886584
Chicago author-date
Lescrauwaet, Emma, Kristl Vonck, Mathieu Sprengers, Robrecht Raedt, Deborah Klooster, Evelien Carrette, and Paul Boon. 2022. “Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy.” FRONTIERS IN NEUROSCIENCE 16. https://doi.org/10.3389/fnins.2022.886584.
Chicago author-date (all authors)
Lescrauwaet, Emma, Kristl Vonck, Mathieu Sprengers, Robrecht Raedt, Deborah Klooster, Evelien Carrette, and Paul Boon. 2022. “Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy.” FRONTIERS IN NEUROSCIENCE 16. doi:10.3389/fnins.2022.886584.
Vancouver
1.
Lescrauwaet E, Vonck K, Sprengers M, Raedt R, Klooster D, Carrette E, et al. Recent advances in the use of focused ultrasound as a treatment for epilepsy. FRONTIERS IN NEUROSCIENCE. 2022;16.
IEEE
[1]
E. Lescrauwaet et al., “Recent advances in the use of focused ultrasound as a treatment for epilepsy,” FRONTIERS IN NEUROSCIENCE, vol. 16, 2022.
@article{8759337,
  abstract     = {{Epilepsy affects about 1% of the population. Approximately one third of patients with epilepsy are drug-resistant (DRE). Resective surgery is an effective treatment for DRE, yet invasive, and not all DRE patients are suitable resective surgery candidates. Focused ultrasound, a novel non-invasive neurointerventional method is currently under investigation as a treatment alternative for DRE. By emitting one or more ultrasound waves, FUS can target structures in the brain at millimeter resolution. High intensity focused ultrasound (HIFU) leads to ablation of tissue and could therefore serve as a non-invasive alternative for resective surgery. It is currently under investigation in clinical trials following the approval of HIFU for essential tremor and Parkinson’s disease. Low intensity focused ultrasound (LIFU) can modulate neuronal activity and could be used to lower cortical neuronal hyper-excitability in epilepsy patients in a non-invasive manner. The seizure-suppressive effect of LIFU has been studied in several preclinical trials, showing promising results. Further investigations are required to demonstrate translation of preclinical results to human subjects.}},
  articleno    = {{886584}},
  author       = {{Lescrauwaet, Emma and Vonck, Kristl and Sprengers, Mathieu and Raedt, Robrecht and Klooster, Deborah and Carrette, Evelien and Boon, Paul}},
  issn         = {{1662-453X}},
  journal      = {{FRONTIERS IN NEUROSCIENCE}},
  keywords     = {{General Neuroscience,high intensity focused ultrasound,low intensity focused ultrasound,refractory epilepsy,non-invasive,neuromodulation}},
  language     = {{eng}},
  pages        = {{10}},
  title        = {{Recent advances in the use of focused ultrasound as a treatment for epilepsy}},
  url          = {{http://doi.org/10.3389/fnins.2022.886584}},
  volume       = {{16}},
  year         = {{2022}},
}

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