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Sequence-Defined Mikto-Arm Star-Shaped Macromolecules

Melissa Reith (UGent) , Irene De Franceschi (UGent) , Matthieu Soete (UGent) , Nezha Badi (UGent) , Resat Aksakal (UGent) and Filip Du Prez (UGent)
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Abstract
The synthesis of sequence-defined, discrete star-shaped macromolecules is a major challenge due to the lack of straightforward and versatile approaches. Here, a robust strategy is proposed that allows not only the preparation of sequence-defined mikto-arm star-shaped macromolecules but also the synthesis of a series of unprecedented discrete, multifunctional complex architectures with molar masses above 11 kDa. The iterative approach reported makes use of readily available building blocks and results in asymmetrically branched macromolecules with high purity and yields, which is showcased with monodisperse miktoarm three-, four-, and five-arm star-shaped structures that were all characterized via LC-MS, MALDI-ToF, and NMR. This effective strategy drastically improves upon synthetic abilities of polymer chemists by enabling simultaneously sequence definition, precision insertion of branching points, as well as the orthogonal end-group functionalization of complex polymeric architectures. The presented approach, which can be translated to different platforms such as peptides and peptoids, is therefore particularly interesting in biomedical applications for which multiple different functional moieties on a single discrete macromolecule are needed.
Keywords
ACRYLATE OLIGOMERS, LIGAND

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MLA
Reith, Melissa, et al. “Sequence-Defined Mikto-Arm Star-Shaped Macromolecules.” JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 144, no. 16, Amer Chemical Soc, 2022, pp. 7236–44, doi:10.1021/jacs.2c00145.
APA
Reith, M., De Franceschi, I., Soete, M., Badi, N., Aksakal, R., & Du Prez, F. (2022). Sequence-Defined Mikto-Arm Star-Shaped Macromolecules. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 144(16), 7236–7244. https://doi.org/10.1021/jacs.2c00145
Chicago author-date
Reith, Melissa, Irene De Franceschi, Matthieu Soete, Nezha Badi, Resat Aksakal, and Filip Du Prez. 2022. “Sequence-Defined Mikto-Arm Star-Shaped Macromolecules.” JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 144 (16): 7236–44. https://doi.org/10.1021/jacs.2c00145.
Chicago author-date (all authors)
Reith, Melissa, Irene De Franceschi, Matthieu Soete, Nezha Badi, Resat Aksakal, and Filip Du Prez. 2022. “Sequence-Defined Mikto-Arm Star-Shaped Macromolecules.” JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 144 (16): 7236–7244. doi:10.1021/jacs.2c00145.
Vancouver
1.
Reith M, De Franceschi I, Soete M, Badi N, Aksakal R, Du Prez F. Sequence-Defined Mikto-Arm Star-Shaped Macromolecules. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2022;144(16):7236–44.
IEEE
[1]
M. Reith, I. De Franceschi, M. Soete, N. Badi, R. Aksakal, and F. Du Prez, “Sequence-Defined Mikto-Arm Star-Shaped Macromolecules,” JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 144, no. 16, pp. 7236–7244, 2022.
@article{8758679,
  abstract     = {{The synthesis of sequence-defined, discrete star-shaped macromolecules is a major challenge due to the lack of straightforward and versatile approaches. Here, a robust strategy is proposed that allows not only the preparation of sequence-defined mikto-arm star-shaped macromolecules but also the synthesis of a series of unprecedented discrete, multifunctional complex architectures with molar masses above 11 kDa. The iterative approach reported makes use of readily available building blocks and results in asymmetrically branched macromolecules with high purity and yields, which is showcased with monodisperse miktoarm three-, four-, and five-arm star-shaped structures that were all characterized via LC-MS, MALDI-ToF, and NMR. This effective strategy drastically improves upon synthetic abilities of polymer chemists by enabling simultaneously sequence definition, precision insertion of branching points, as well as the orthogonal end-group functionalization of complex polymeric architectures. The presented approach, which can be translated to different platforms such as peptides and peptoids, is therefore particularly interesting in biomedical applications for which multiple different functional moieties on a single discrete macromolecule are needed.}},
  author       = {{Reith, Melissa and De Franceschi, Irene and Soete, Matthieu and Badi, Nezha and Aksakal, Resat and Du Prez, Filip}},
  issn         = {{0002-7863}},
  journal      = {{JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}},
  keywords     = {{ACRYLATE OLIGOMERS,LIGAND}},
  language     = {{eng}},
  number       = {{16}},
  pages        = {{7236--7244}},
  publisher    = {{Amer Chemical Soc}},
  title        = {{Sequence-Defined Mikto-Arm Star-Shaped Macromolecules}},
  url          = {{http://dx.doi.org/10.1021/jacs.2c00145}},
  volume       = {{144}},
  year         = {{2022}},
}

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