Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study)

van der Weijst, Lotte; Aguado-Barrera, Miguel E.; Azria, David; Berkovic, Patrick; Boisselier, Pierre; Briers, Erik; Bultijnck, Renée; Calvo-Crespo, Patricia; Chang-Claude, Jenny; Choudhury, Ananya; Defraene, Gilles; Demontois, Sylvian; Dunning, Alison M.; Elliott, Rebecca M.; Ennis, Dawn; Faivre-Finn, Corinne; Franceschini, Marzia; Gutiérrez-Enríquez, Sara; Herskind, Carsten; Higginson, Daniel S.; Kerns, Sarah L.; Johnson, Kerstie; Mollà, Meritxell; Lambrecht, Maarten; Ramos, Mónica; Rancati, Tiziana; Rimner, Andreas; Rosenstein, Barry S.; De Ruysscher, Dirk; Salem, Ahmed; Sangalli, Claudia; Seibold, Petra; Sosa-Fajardo, Paloma; Sperk, Elena; Stobart, Hilary; Summersgill, Holly; Surmont, Veerle; Symonds, Paul; Taboada-Lorenzo, Begoña; Talbot, Christopher J.; Valdagni, Riccardo; Vega, Ana; Veldeman, Liv; Veldwijk, Marlon R.; Ward, Tim; Webb, Adam; West, Catharine M.L.; Lievens, Yolande

Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study)

Lotte van der Weijst, Miguel E. Aguado-Barrera, David Azria, Patrick Berkovic, Pierre Boisselier, Erik Briers, Renée Bultijnck (UGent) , Patricia Calvo-Crespo, Jenny Chang-Claude, Ananya Choudhury, et al.

(2022) LUNG CANCER. 166. p.228-241

Author

Lotte van der Weijst, Miguel E. Aguado-Barrera, David Azria, Patrick Berkovic, Pierre Boisselier, Erik Briers, Renée Bultijnck (UGent) , Patricia Calvo-Crespo, Jenny Chang-Claude, Ananya Choudhury, Gilles Defraene, Sylvian Demontois, Alison M. Dunning, Rebecca M. Elliott, Dawn Ennis, Corinne Faivre-Finn, Marzia Franceschini, Sara Gutiérrez-Enríquez, Carsten Herskind, Daniel S. Higginson, Sarah L. Kerns, Kerstie Johnson, Meritxell Mollà, Maarten Lambrecht, Mónica Ramos, Tiziana Rancati, Andreas Rimner, Barry S. Rosenstein, Dirk De Ruysscher, Ahmed Salem, Claudia Sangalli, Petra Seibold, Paloma Sosa-Fajardo, Elena Sperk, Hilary Stobart, Holly Summersgill, Veerle Surmont (UGent) , Paul Symonds, Begoña Taboada-Lorenzo, Christopher J. Talbot, Riccardo Valdagni, Ana Vega, Liv Veldeman (UGent) , Marlon R. Veldwijk, Tim Ward, Adam Webb, Catharine M.L. West and Yolande Lievens (UGent)

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Project

Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors

Abstract

Objectives: Radiotherapy-induced toxicity may negatively impact health-related quality of life (HRQoL). This report investigates the impact of curative-intent radiotherapy on HRQoL and toxicity in early stage and locally-advanced non-small cell lung cancer patients treated with radiotherapy or chemo-radiotherapy enrolled in the observational prospective REQUITE study.& nbsp;Materials and methods: HRQoL was assessed using the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire up to 2 years post radiotherapy. Eleven toxicities were scored by clinicians using the Common Terminology Criteria for Adverse Events (CTCAE) version 4. Toxicity scores were calculated by subtracting baseline values. Mixed model analyses were applied to determine statistical significance (p & LE; 0.01). Meaningful clinical important differences (MCID) were determined for changes in HRQoL. Analysis was performed on the overall data, different radiotherapy techniques, multimodality treatments and disease stages.& nbsp;Results: Data of 510 patients were analysed. There was no significant change in HRQoL or its domains, except for deterioration in cognitive functioning (p = 0.01). Radiotherapy technique had no significant impact on HRQoL. The addition of chemotherapy was significantly associated with HRQoL over time (p <.001). Overall toxicity did not significantly change over time. Acute toxicities of radiation-dermatitis (p =.003), dysphagia (p =.002) and esophagitis (p <.001) peaked at 3 months and decreased thereafter. Pneumonitis initially deteriorated but improved significantly after 12 months (p =.011). A proportion of patients experienced meaningful clinically important improvements and deteriorations in overall HRQoL and its domains. In some patients, pre-treatment symptoms improved gradually.& nbsp;Conclusions: While overall HRQoL and toxicity did not change over time, some patients improved, whereas others experienced acute radiotherapy-induced toxicities and deteriorated HRQoL, especially physical and cognitive functioning. Patient characteristics, more so than radiotherapy technique and treatment modality, impact post-radiotherapy toxicity and HRQoL outcomes. This stresses the importance of considering the potential impact of radiotherapy on individuals' HRQoL, symptoms and toxicity in treatment decision-making.

Keywords

Cancer Research, Pulmonary and Respiratory Medicine, Oncology, REPORTED OUTCOME MEASURES, RADIATION-THERAPY IMRT, CLINICAL-TRIALS, CONCURRENT CHEMOTHERAPY, DOSE-ESCALATION, EORTC QLQ-LC13, END-POINTS, IMPACT, SURVIVAL, QLQ-C30

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Citation

Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8758470

MLA: van der Weijst, Lotte, et al. “Overview of Health-Related Quality of Life and Toxicity of Non-Small Cell Lung Cancer Patients Receiving Curative-Intent Radiotherapy in a Real-Life Setting (the REQUITE Study).” LUNG CANCER, vol. 166, 2022, pp. 228–41, doi:10.1016/j.lungcan.2022.03.010.
APA: van der Weijst, L., Aguado-Barrera, M. E., Azria, D., Berkovic, P., Boisselier, P., Briers, E., … Lievens, Y. (2022). Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study). LUNG CANCER, 166, 228–241. https://doi.org/10.1016/j.lungcan.2022.03.010
Chicago author-date: Weijst, Lotte van der, Miguel E. Aguado-Barrera, David Azria, Patrick Berkovic, Pierre Boisselier, Erik Briers, Renée Bultijnck, et al. 2022. “Overview of Health-Related Quality of Life and Toxicity of Non-Small Cell Lung Cancer Patients Receiving Curative-Intent Radiotherapy in a Real-Life Setting (the REQUITE Study).” LUNG CANCER 166: 228–41. https://doi.org/10.1016/j.lungcan.2022.03.010.
Chicago author-date (all authors): van der Weijst, Lotte, Miguel E. Aguado-Barrera, David Azria, Patrick Berkovic, Pierre Boisselier, Erik Briers, Renée Bultijnck, Patricia Calvo-Crespo, Jenny Chang-Claude, Ananya Choudhury, Gilles Defraene, Sylvian Demontois, Alison M. Dunning, Rebecca M. Elliott, Dawn Ennis, Corinne Faivre-Finn, Marzia Franceschini, Sara Gutiérrez-Enríquez, Carsten Herskind, Daniel S. Higginson, Sarah L. Kerns, Kerstie Johnson, Meritxell Mollà, Maarten Lambrecht, Mónica Ramos, Tiziana Rancati, Andreas Rimner, Barry S. Rosenstein, Dirk De Ruysscher, Ahmed Salem, Claudia Sangalli, Petra Seibold, Paloma Sosa-Fajardo, Elena Sperk, Hilary Stobart, Holly Summersgill, Veerle Surmont, Paul Symonds, Begoña Taboada-Lorenzo, Christopher J. Talbot, Riccardo Valdagni, Ana Vega, Liv Veldeman, Marlon R. Veldwijk, Tim Ward, Adam Webb, Catharine M.L. West, and Yolande Lievens. 2022. “Overview of Health-Related Quality of Life and Toxicity of Non-Small Cell Lung Cancer Patients Receiving Curative-Intent Radiotherapy in a Real-Life Setting (the REQUITE Study).” LUNG CANCER 166: 228–241. doi:10.1016/j.lungcan.2022.03.010.
Vancouver: 1.
van der Weijst L, Aguado-Barrera ME, Azria D, Berkovic P, Boisselier P, Briers E, et al. Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study). LUNG CANCER. 2022;166:228–41.
IEEE: [1]
L. van der Weijst et al., “Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study),” LUNG CANCER, vol. 166, pp. 228–241, 2022.

@article{8758470,
  abstract     = {{Objectives: Radiotherapy-induced toxicity may negatively impact health-related quality of life (HRQoL). This report investigates the impact of curative-intent radiotherapy on HRQoL and toxicity in early stage and locally-advanced non-small cell lung cancer patients treated with radiotherapy or chemo-radiotherapy enrolled in the observational prospective REQUITE study.& nbsp;Materials and methods: HRQoL was assessed using the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire up to 2 years post radiotherapy. Eleven toxicities were scored by clinicians using the Common Terminology Criteria for Adverse Events (CTCAE) version 4. Toxicity scores were calculated by subtracting baseline values. Mixed model analyses were applied to determine statistical significance (p & LE; 0.01). Meaningful clinical important differences (MCID) were determined for changes in HRQoL. Analysis was performed on the overall data, different radiotherapy techniques, multimodality treatments and disease stages.& nbsp;Results: Data of 510 patients were analysed. There was no significant change in HRQoL or its domains, except for deterioration in cognitive functioning (p = 0.01). Radiotherapy technique had no significant impact on HRQoL. The addition of chemotherapy was significantly associated with HRQoL over time (p <.001). Overall toxicity did not significantly change over time. Acute toxicities of radiation-dermatitis (p =.003), dysphagia (p =.002) and esophagitis (p <.001) peaked at 3 months and decreased thereafter. Pneumonitis initially deteriorated but improved significantly after 12 months (p =.011). A proportion of patients experienced meaningful clinically important improvements and deteriorations in overall HRQoL and its domains. In some patients, pre-treatment symptoms improved gradually.& nbsp;Conclusions: While overall HRQoL and toxicity did not change over time, some patients improved, whereas others experienced acute radiotherapy-induced toxicities and deteriorated HRQoL, especially physical and cognitive functioning. Patient characteristics, more so than radiotherapy technique and treatment modality, impact post-radiotherapy toxicity and HRQoL outcomes. This stresses the importance of considering the potential impact of radiotherapy on individuals' HRQoL, symptoms and toxicity in treatment decision-making.}},
  author       = {{van der Weijst, Lotte and Aguado-Barrera, Miguel E. and Azria, David and Berkovic, Patrick and Boisselier, Pierre and Briers, Erik and Bultijnck, Renée and Calvo-Crespo, Patricia and Chang-Claude, Jenny and Choudhury, Ananya and Defraene, Gilles and Demontois, Sylvian and Dunning, Alison M. and Elliott, Rebecca M. and Ennis, Dawn and Faivre-Finn, Corinne and Franceschini, Marzia and Gutiérrez-Enríquez, Sara and Herskind, Carsten and Higginson, Daniel S. and Kerns, Sarah L. and Johnson, Kerstie and Mollà, Meritxell and Lambrecht, Maarten and Ramos, Mónica and Rancati, Tiziana and Rimner, Andreas and Rosenstein, Barry S. and De Ruysscher, Dirk and Salem, Ahmed and Sangalli, Claudia and Seibold, Petra and Sosa-Fajardo, Paloma and Sperk, Elena and Stobart, Hilary and Summersgill, Holly and Surmont, Veerle and Symonds, Paul and Taboada-Lorenzo, Begoña and Talbot, Christopher J. and Valdagni, Riccardo and Vega, Ana and Veldeman, Liv and Veldwijk, Marlon R. and Ward, Tim and Webb, Adam and West, Catharine M.L. and Lievens, Yolande}},
  issn         = {{0169-5002}},
  journal      = {{LUNG CANCER}},
  keywords     = {{Cancer Research,Pulmonary and Respiratory Medicine,Oncology,REPORTED OUTCOME MEASURES,RADIATION-THERAPY IMRT,CLINICAL-TRIALS,CONCURRENT CHEMOTHERAPY,DOSE-ESCALATION,EORTC QLQ-LC13,END-POINTS,IMPACT,SURVIVAL,QLQ-C30}},
  language     = {{eng}},
  pages        = {{228--241}},
  title        = {{Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study)}},
  url          = {{http://doi.org/10.1016/j.lungcan.2022.03.010}},
  volume       = {{166}},
  year         = {{2022}},
}

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Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study)

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