Late-stage diversification of peptidomimetics and oligopeptides via gold-catalyzed post-Ugi cyclization
- Author
- Liangliang Song, Chao Liu, Guilong Tian, Luc Van Meervelt, Johan Van der Eycken (UGent) and Erik V. Van der Eycken
- Organization
- Abstract
- A chemo-and regioselective gold-catalyzed tandem 6-endo-dig cyclization/enyne cycloisomerization/1,2migration process for the synthesis of decorated peptidomimetics is developed. Various migrating groups such as aryl, heteroaryl and alkyl are tolerated in this method under mild conditions. This protocol is successfully utilized to modify various oligopeptides, including substrates bearing the drug amantadine, in a rapid and step economical manner through the combination with the Ugi reaction.
- Keywords
- MICHAEL CASCADE REACTION, MULTICOMPONENT REACTIONS, DEAROMATIZATION, TRANSFORMATIONS, CYCLOADDITION, CONSTRUCTION, COMPLEXES, CHANNEL, DESIGN, Peptidomimetic, Oligopeptide, Gold, Post-Ugi, Cyclization
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8758417
- MLA
- Song, Liangliang, et al. “Late-Stage Diversification of Peptidomimetics and Oligopeptides via Gold-Catalyzed Post-Ugi Cyclization.” MOLECULAR CATALYSIS, vol. 522, 2022, doi:10.1016/j.mcat.2022.112240.
- APA
- Song, L., Liu, C., Tian, G., Van Meervelt, L., Van der Eycken, J., & Van der Eycken, E. V. (2022). Late-stage diversification of peptidomimetics and oligopeptides via gold-catalyzed post-Ugi cyclization. MOLECULAR CATALYSIS, 522. https://doi.org/10.1016/j.mcat.2022.112240
- Chicago author-date
- Song, Liangliang, Chao Liu, Guilong Tian, Luc Van Meervelt, Johan Van der Eycken, and Erik V. Van der Eycken. 2022. “Late-Stage Diversification of Peptidomimetics and Oligopeptides via Gold-Catalyzed Post-Ugi Cyclization.” MOLECULAR CATALYSIS 522. https://doi.org/10.1016/j.mcat.2022.112240.
- Chicago author-date (all authors)
- Song, Liangliang, Chao Liu, Guilong Tian, Luc Van Meervelt, Johan Van der Eycken, and Erik V. Van der Eycken. 2022. “Late-Stage Diversification of Peptidomimetics and Oligopeptides via Gold-Catalyzed Post-Ugi Cyclization.” MOLECULAR CATALYSIS 522. doi:10.1016/j.mcat.2022.112240.
- Vancouver
- 1.Song L, Liu C, Tian G, Van Meervelt L, Van der Eycken J, Van der Eycken EV. Late-stage diversification of peptidomimetics and oligopeptides via gold-catalyzed post-Ugi cyclization. MOLECULAR CATALYSIS. 2022;522.
- IEEE
- [1]L. Song, C. Liu, G. Tian, L. Van Meervelt, J. Van der Eycken, and E. V. Van der Eycken, “Late-stage diversification of peptidomimetics and oligopeptides via gold-catalyzed post-Ugi cyclization,” MOLECULAR CATALYSIS, vol. 522, 2022.
@article{8758417,
abstract = {{A chemo-and regioselective gold-catalyzed tandem 6-endo-dig cyclization/enyne cycloisomerization/1,2migration process for the synthesis of decorated peptidomimetics is developed. Various migrating groups such as aryl, heteroaryl and alkyl are tolerated in this method under mild conditions. This protocol is successfully utilized to modify various oligopeptides, including substrates bearing the drug amantadine, in a rapid and step economical manner through the combination with the Ugi reaction.}},
articleno = {{112240}},
author = {{Song, Liangliang and Liu, Chao and Tian, Guilong and Van Meervelt, Luc and Van der Eycken, Johan and Van der Eycken, Erik V.}},
issn = {{2468-8231}},
journal = {{MOLECULAR CATALYSIS}},
keywords = {{MICHAEL CASCADE REACTION,MULTICOMPONENT REACTIONS,DEAROMATIZATION,TRANSFORMATIONS,CYCLOADDITION,CONSTRUCTION,COMPLEXES,CHANNEL,DESIGN,Peptidomimetic,Oligopeptide,Gold,Post-Ugi,Cyclization}},
language = {{eng}},
pages = {{6}},
title = {{Late-stage diversification of peptidomimetics and oligopeptides via gold-catalyzed post-Ugi cyclization}},
url = {{http://doi.org/10.1016/j.mcat.2022.112240}},
volume = {{522}},
year = {{2022}},
}
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