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Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair

Nele Pien (UGent) , Ynse Van de Maele, Laurens Parmentier (UGent) , Marguerite Meeremans (UGent) , A. Mignon, Catharina De Schauwer (UGent) , Ian Peeters (UGent) , Laura De Wilde, Ann Martens (UGent) , D. Mantovani, et al.
(2022) JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. 33(6).
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Abstract
Hand tendon injuries represent a major clinical problem and might dramatically diminish a patient's life quality. In this study, a targeted solution for flexor tendon repair was developed by combining a mechanical and biological approach. To this end, a novel acrylate-endcapped urethane-based polymer (AUP) was synthesized and its physico-chemical properties were characterized. Next, tubular repair constructs were developed using electrospinning of the AUP material with incorporated naproxen and hyaluronic acid (i.e. anti-inflammatory and anti-adhesion compounds, respectively), and with a tubular braid as mechanical reinforcement. Tensile testing of the repair constructs using ex vivo sheep tendons showed that the developed repair constructs fulfilled the required mechanical properties for tendon repair (i.e. minimal ultimate stress of 4 MPa), with an ultimate stress of 6.4 +/- 0.6 MPa. Moreover, in vitro biological assays showed that the developed repair tubes and the incorporated bioactive components were non-cytotoxic. In addition, when equine tenocytes and mesenchymal stem cells were co-cultured with the repair tubes, an increased production of collagen and non-collagenous proteins was observed. In conclusion, this novel construct in which a mechanical approach (fulfilling the required mechanical properties) was combined with a biological approach (incorporation of bioactive compounds), shows potential as flexor tendon repair application.
Keywords
PERITENDINOUS ADHESIONS, NANOFIBROUS MEMBRANES, FLEXOR, PREVENTION, INJURIES, BIOMECHANICS, SCAFFOLDS

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MLA
Pien, Nele, et al. “Design of an Electrospun Tubular Construct Combining a Mechanical and Biological Approach to Improve Tendon Repair.” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, vol. 33, no. 6, 2022, doi:10.1007/s10856-022-06673-4.
APA
Pien, N., Van de Maele, Y., Parmentier, L., Meeremans, M., Mignon, A., De Schauwer, C., … Dubruel, P. (2022). Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 33(6). https://doi.org/10.1007/s10856-022-06673-4
Chicago author-date
Pien, Nele, Ynse Van de Maele, Laurens Parmentier, Marguerite Meeremans, A. Mignon, Catharina De Schauwer, Ian Peeters, et al. 2022. “Design of an Electrospun Tubular Construct Combining a Mechanical and Biological Approach to Improve Tendon Repair.” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 33 (6). https://doi.org/10.1007/s10856-022-06673-4.
Chicago author-date (all authors)
Pien, Nele, Ynse Van de Maele, Laurens Parmentier, Marguerite Meeremans, A. Mignon, Catharina De Schauwer, Ian Peeters, Laura De Wilde, Ann Martens, D. Mantovani, Sandra Van Vlierberghe, and Peter Dubruel. 2022. “Design of an Electrospun Tubular Construct Combining a Mechanical and Biological Approach to Improve Tendon Repair.” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 33 (6). doi:10.1007/s10856-022-06673-4.
Vancouver
1.
Pien N, Van de Maele Y, Parmentier L, Meeremans M, Mignon A, De Schauwer C, et al. Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. 2022;33(6).
IEEE
[1]
N. Pien et al., “Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair,” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, vol. 33, no. 6, 2022.
@article{8757731,
  abstract     = {{Hand tendon injuries represent a major clinical problem and might dramatically diminish a patient's life quality. In this study, a targeted solution for flexor tendon repair was developed by combining a mechanical and biological approach. To this end, a novel acrylate-endcapped urethane-based polymer (AUP) was synthesized and its physico-chemical properties were characterized. Next, tubular repair constructs were developed using electrospinning of the AUP material with incorporated naproxen and hyaluronic acid (i.e. anti-inflammatory and anti-adhesion compounds, respectively), and with a tubular braid as mechanical reinforcement. Tensile testing of the repair constructs using ex vivo sheep tendons showed that the developed repair constructs fulfilled the required mechanical properties for tendon repair (i.e. minimal ultimate stress of 4 MPa), with an ultimate stress of 6.4 +/- 0.6 MPa. Moreover, in vitro biological assays showed that the developed repair tubes and the incorporated bioactive components were non-cytotoxic. In addition, when equine tenocytes and mesenchymal stem cells were co-cultured with the repair tubes, an increased production of collagen and non-collagenous proteins was observed. In conclusion, this novel construct in which a mechanical approach (fulfilling the required mechanical properties) was combined with a biological approach (incorporation of bioactive compounds), shows potential as flexor tendon repair application.}},
  articleno    = {{51}},
  author       = {{Pien, Nele and Van de Maele, Ynse and Parmentier, Laurens and Meeremans, Marguerite and Mignon, A. and De Schauwer, Catharina and Peeters, Ian and De Wilde, Laura and Martens, Ann and Mantovani, D. and Van Vlierberghe, Sandra and Dubruel, Peter}},
  issn         = {{0957-4530}},
  journal      = {{JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE}},
  keywords     = {{PERITENDINOUS ADHESIONS,NANOFIBROUS MEMBRANES,FLEXOR,PREVENTION,INJURIES,BIOMECHANICS,SCAFFOLDS}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{17}},
  title        = {{Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair}},
  url          = {{http://dx.doi.org/10.1007/s10856-022-06673-4}},
  volume       = {{33}},
  year         = {{2022}},
}
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