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Emerging paradigms in type 2 immunity

Hamida Hammad (UGent) , Nincy Debeuf (UGent) , Helena Catharine Aegerter (UGent) , Andrew Brown (UGent) and Bart Lambrecht (UGent)
(2022) ANNUAL REVIEW OF IMMUNOLOGY. 40. p.443-467
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Abstract
A principal purpose of type 2 immunity was thought to be defense against large parasites, but it also functions in the restoration of homeostasis, such as toxin clearance following snake bites. In other cases, like allergy, the type 2 T helper (Th2) cytokines and cells present in the environment are detrimental and cause diseases. In recent years, the recognition of cell heterogeneity within Th2-associated cell populations has revealed specific functions of cells with a particular phenotype or gene signature. In addition, here we discuss the recent data regarding heterogeneity of type 2 immunity-related cells, as well as their newly identified role in a variety of processes ranging from involvement in respiratory viral infections [especially in the context of the recent COVID-19 (coronavirus disease 2019) pandemic] to control of cancer development or of metabolic homeostasis.
Keywords
type 2 immunity, neuroimmune interactions, respiratory viruses, cancer, metabolism, INNATE LYMPHOID-CELLS, MAST-CELLS, EOSINOPHILS, EXPRESSION, IL-33, INFLAMMATION, ASTHMA, FIBROSIS, HYPERRESPONSIVENESS, POPULATIONS

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Citation

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MLA
Hammad, Hamida, et al. “Emerging Paradigms in Type 2 Immunity.” ANNUAL REVIEW OF IMMUNOLOGY, vol. 40, 2022, pp. 443–67, doi:10.1146/annurev-immunol-101320-030339.
APA
Hammad, H., Debeuf, N., Aegerter, H. C., Brown, A., & Lambrecht, B. (2022). Emerging paradigms in type 2 immunity. ANNUAL REVIEW OF IMMUNOLOGY, 40, 443–467. https://doi.org/10.1146/annurev-immunol-101320-030339
Chicago author-date
Hammad, Hamida, Nincy Debeuf, Helena Catharine Aegerter, Andrew Brown, and Bart Lambrecht. 2022. “Emerging Paradigms in Type 2 Immunity.” ANNUAL REVIEW OF IMMUNOLOGY 40: 443–67. https://doi.org/10.1146/annurev-immunol-101320-030339.
Chicago author-date (all authors)
Hammad, Hamida, Nincy Debeuf, Helena Catharine Aegerter, Andrew Brown, and Bart Lambrecht. 2022. “Emerging Paradigms in Type 2 Immunity.” ANNUAL REVIEW OF IMMUNOLOGY 40: 443–467. doi:10.1146/annurev-immunol-101320-030339.
Vancouver
1.
Hammad H, Debeuf N, Aegerter HC, Brown A, Lambrecht B. Emerging paradigms in type 2 immunity. ANNUAL REVIEW OF IMMUNOLOGY. 2022;40:443–67.
IEEE
[1]
H. Hammad, N. Debeuf, H. C. Aegerter, A. Brown, and B. Lambrecht, “Emerging paradigms in type 2 immunity,” ANNUAL REVIEW OF IMMUNOLOGY, vol. 40, pp. 443–467, 2022.
@article{8756768,
  abstract     = {{A principal purpose of type 2 immunity was thought to be defense against large parasites, but it also functions in the restoration of homeostasis, such as toxin clearance following snake bites. In other cases, like allergy, the type 2 T helper (Th2) cytokines and cells present in the environment are detrimental and cause diseases. In recent years, the recognition of cell heterogeneity within Th2-associated cell populations has revealed specific functions of cells with a particular phenotype or gene signature. In addition, here we discuss the recent data regarding heterogeneity of type 2 immunity-related cells, as well as their newly identified role in a variety of processes ranging from involvement in respiratory viral infections [especially in the context of the recent COVID-19 (coronavirus disease 2019) pandemic] to control of cancer development or of metabolic homeostasis.}},
  author       = {{Hammad, Hamida and Debeuf, Nincy and Aegerter, Helena Catharine and Brown, Andrew and Lambrecht, Bart}},
  issn         = {{0732-0582}},
  journal      = {{ANNUAL REVIEW OF IMMUNOLOGY}},
  keywords     = {{type 2 immunity,neuroimmune interactions,respiratory viruses,cancer,metabolism,INNATE LYMPHOID-CELLS,MAST-CELLS,EOSINOPHILS,EXPRESSION,IL-33,INFLAMMATION,ASTHMA,FIBROSIS,HYPERRESPONSIVENESS,POPULATIONS}},
  language     = {{eng}},
  pages        = {{443--467}},
  title        = {{Emerging paradigms in type 2 immunity}},
  url          = {{http://doi.org/10.1146/annurev-immunol-101320-030339}},
  volume       = {{40}},
  year         = {{2022}},
}
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