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A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago

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Abstract
The STORR gene fusion event is considered essential for the evolution of the promorphinan/morphinan subclass of benzylisoquinoline alkaloids (BIAs) in opium poppy as the resulting bi-modular protein performs the isomerization of (S)- to (R)-reticuline essential for their biosynthesis. Here, we show that of the 12 Papaver species analysed those containing the STORR gene fusion also contain promorphinans/morphinans with one important exception. P. californicum encodes a functionally conserved STORR but does not produce promorphinans/morphinans. We also show that the gene fusion event occurred only once, between 16.8-24.1 million years ago before the separation of P. californicum from other Clade 2 Papaver species. The most abundant BIA in P. californicum is (R)-glaucine, a member of the aporphine subclass of BIAs, raising the possibility that STORR, once evolved, contributes to the biosynthesis of more than just the promorphinan/morphinan subclass of BIAs in the Papaveraceae. The STORR gene fusion event is a key step in the evolution of benzylisoquinoline alkaloid metabolism in opium poppy. Here, the authors combine phylogenetic, transcriptomic, metabolomic, biochemical and genomic analyses to show the STORR gene fusion occurred only once between 16.8-24.1 million years ago in Papaver species.
Keywords
General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, MORPHINE BIOSYNTHESIS, SEQUENCE-ANALYSIS, PLANT, IDENTIFICATION, TRANSCRIPT, DISCOVERY, PHYLOGENY, ALKALOIDS, EVOLUTION, ALIGNMENT

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MLA
Catania, Theresa, et al. “A Functionally Conserved STORR Gene Fusion in Papaver Species That Diverged 16.8 Million Years Ago.” NATURE COMMUNICATIONS, vol. 13, no. 1, 2022, doi:10.1038/s41467-022-30856-w.
APA
Catania, T., Li, Y., Winzer, T., Harvey, D., Meade, F., Caridi, A., … Graham, I. A. (2022). A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago. NATURE COMMUNICATIONS, 13(1). https://doi.org/10.1038/s41467-022-30856-w
Chicago author-date
Catania, Theresa, Yi Li, Thilo Winzer, David Harvey, Fergus Meade, Anna Caridi, Andrew Leech, et al. 2022. “A Functionally Conserved STORR Gene Fusion in Papaver Species That Diverged 16.8 Million Years Ago.” NATURE COMMUNICATIONS 13 (1). https://doi.org/10.1038/s41467-022-30856-w.
Chicago author-date (all authors)
Catania, Theresa, Yi Li, Thilo Winzer, David Harvey, Fergus Meade, Anna Caridi, Andrew Leech, Tony R. Larson, Zemin Ning, Jiyang Chang, Yves Van de Peer, and Ian A. Graham. 2022. “A Functionally Conserved STORR Gene Fusion in Papaver Species That Diverged 16.8 Million Years Ago.” NATURE COMMUNICATIONS 13 (1). doi:10.1038/s41467-022-30856-w.
Vancouver
1.
Catania T, Li Y, Winzer T, Harvey D, Meade F, Caridi A, et al. A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago. NATURE COMMUNICATIONS. 2022;13(1).
IEEE
[1]
T. Catania et al., “A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago,” NATURE COMMUNICATIONS, vol. 13, no. 1, 2022.
@article{8755965,
  abstract     = {{The STORR gene fusion event is considered essential for the evolution of the promorphinan/morphinan subclass of benzylisoquinoline alkaloids (BIAs) in opium poppy as the resulting bi-modular protein performs the isomerization of (S)- to (R)-reticuline essential for their biosynthesis. Here, we show that of the 12 Papaver species analysed those containing the STORR gene fusion also contain promorphinans/morphinans with one important exception. P. californicum encodes a functionally conserved STORR but does not produce promorphinans/morphinans. We also show that the gene fusion event occurred only once, between 16.8-24.1 million years ago before the separation of P. californicum from other Clade 2 Papaver species. The most abundant BIA in P. californicum is (R)-glaucine, a member of the aporphine subclass of BIAs, raising the possibility that STORR, once evolved, contributes to the biosynthesis of more than just the promorphinan/morphinan subclass of BIAs in the Papaveraceae.

The STORR gene fusion event is a key step in the evolution of benzylisoquinoline alkaloid metabolism in opium poppy. Here, the authors combine phylogenetic, transcriptomic, metabolomic, biochemical and genomic analyses to show the STORR gene fusion occurred only once between 16.8-24.1 million years ago in Papaver species.}},
  articleno    = {{3150}},
  author       = {{Catania, Theresa and Li, Yi and Winzer, Thilo and Harvey, David and Meade, Fergus and Caridi, Anna and Leech, Andrew and Larson, Tony R. and Ning, Zemin and Chang, Jiyang and Van de Peer, Yves and Graham, Ian A.}},
  issn         = {{2041-1723}},
  journal      = {{NATURE COMMUNICATIONS}},
  keywords     = {{General Physics and Astronomy,General Biochemistry,Genetics and Molecular Biology,General Chemistry,MORPHINE BIOSYNTHESIS,SEQUENCE-ANALYSIS,PLANT,IDENTIFICATION,TRANSCRIPT,DISCOVERY,PHYLOGENY,ALKALOIDS,EVOLUTION,ALIGNMENT}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{11}},
  title        = {{A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago}},
  url          = {{http://doi.org/10.1038/s41467-022-30856-w}},
  volume       = {{13}},
  year         = {{2022}},
}

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