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Total lipid concentration of hairs increases after successful attenuation of extrahepatic portosystemic shunts in dogs

Nausikaa Devriendt (UGent) , Tania Rodrigues, Sophie Vandenabeele (UGent) , Dominique Paepe (UGent) , Emmelie Stock (UGent) and Hilde De Rooster (UGent)
(2022) VETERINARY DERMATOLOGY. 33(5). p.371-377
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Organization
Abstract
Background Skin and coat quality can reflect nutritional deficiencies in humans and dogs with liver diseases. Hypothesis/Objectives Determine skin and coat quality based on a scoring protocol and skin biopsies in dogs with an extrahepatic portosystemic shunt (EHPSS), and determine total lipid concentrations in hairs of dogs at time of surgery and 3 months after successful shunt closure. Animals Ten client-owned dogs that underwent successful gradual attenuation of EHPSS, as defined by transsplenic portal scintigraphy, were included. Materials and methods A prospective cohort study was performed. All dogs underwent gradual attenuation of the EHPSS. Skin and coat scoring was performed at diagnosis, surgery, and 1 and 3 months postoperatively. Hair was plucked from the lumbar region for total lipid analysis and an 8 mm punch skin biopsy was taken at time of surgery and 3 months postoperatively, when the dogs underwent transsplenic portal scintigraphy to determine EHPSS closure. Results No significant differences were observed in skin and coat scoring over time. Total lipid concentrations of hairs increased significantly from surgery to 3 months postoperatively [30 mu g/mg hair (13-56 mu g/mg hair) to 47 mu g/mg hair (25-63 mu g/mg hair); p = 0.005]. Skin biopsies showed the presence of significantly more scales 3 months postoperatively (p = 0.018). Conclusions and clinical relevance A significant increase in total lipid concentrations in hairs suggests that successful surgical attenuation of EHPSS improves either intestinal absorption of lipids, fat metabolism in the liver, or a combination of both.
Keywords
General Veterinary, canine, dermatology, hair, hepatopathy, internal medicine, lipids, PORTACAVAL-SHUNT, SKIN, METABOLISM, LESIONS

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MLA
Devriendt, Nausikaa, et al. “Total Lipid Concentration of Hairs Increases after Successful Attenuation of Extrahepatic Portosystemic Shunts in Dogs.” VETERINARY DERMATOLOGY, vol. 33, no. 5, 2022, pp. 371–77, doi:10.1111/vde.13081.
APA
Devriendt, N., Rodrigues, T., Vandenabeele, S., Paepe, D., Stock, E., & De Rooster, H. (2022). Total lipid concentration of hairs increases after successful attenuation of extrahepatic portosystemic shunts in dogs. VETERINARY DERMATOLOGY, 33(5), 371–377. https://doi.org/10.1111/vde.13081
Chicago author-date
Devriendt, Nausikaa, Tania Rodrigues, Sophie Vandenabeele, Dominique Paepe, Emmelie Stock, and Hilde De Rooster. 2022. “Total Lipid Concentration of Hairs Increases after Successful Attenuation of Extrahepatic Portosystemic Shunts in Dogs.” VETERINARY DERMATOLOGY 33 (5): 371–77. https://doi.org/10.1111/vde.13081.
Chicago author-date (all authors)
Devriendt, Nausikaa, Tania Rodrigues, Sophie Vandenabeele, Dominique Paepe, Emmelie Stock, and Hilde De Rooster. 2022. “Total Lipid Concentration of Hairs Increases after Successful Attenuation of Extrahepatic Portosystemic Shunts in Dogs.” VETERINARY DERMATOLOGY 33 (5): 371–377. doi:10.1111/vde.13081.
Vancouver
1.
Devriendt N, Rodrigues T, Vandenabeele S, Paepe D, Stock E, De Rooster H. Total lipid concentration of hairs increases after successful attenuation of extrahepatic portosystemic shunts in dogs. VETERINARY DERMATOLOGY. 2022;33(5):371–7.
IEEE
[1]
N. Devriendt, T. Rodrigues, S. Vandenabeele, D. Paepe, E. Stock, and H. De Rooster, “Total lipid concentration of hairs increases after successful attenuation of extrahepatic portosystemic shunts in dogs,” VETERINARY DERMATOLOGY, vol. 33, no. 5, pp. 371–377, 2022.
@article{8755336,
  abstract     = {{Background Skin and coat quality can reflect nutritional deficiencies in humans and dogs with liver diseases. Hypothesis/Objectives Determine skin and coat quality based on a scoring protocol and skin biopsies in dogs with an extrahepatic portosystemic shunt (EHPSS), and determine total lipid concentrations in hairs of dogs at time of surgery and 3 months after successful shunt closure. Animals Ten client-owned dogs that underwent successful gradual attenuation of EHPSS, as defined by transsplenic portal scintigraphy, were included. Materials and methods A prospective cohort study was performed. All dogs underwent gradual attenuation of the EHPSS. Skin and coat scoring was performed at diagnosis, surgery, and 1 and 3 months postoperatively. Hair was plucked from the lumbar region for total lipid analysis and an 8 mm punch skin biopsy was taken at time of surgery and 3 months postoperatively, when the dogs underwent transsplenic portal scintigraphy to determine EHPSS closure. Results No significant differences were observed in skin and coat scoring over time. Total lipid concentrations of hairs increased significantly from surgery to 3 months postoperatively [30 mu g/mg hair (13-56 mu g/mg hair) to 47 mu g/mg hair (25-63 mu g/mg hair); p = 0.005]. Skin biopsies showed the presence of significantly more scales 3 months postoperatively (p = 0.018). Conclusions and clinical relevance A significant increase in total lipid concentrations in hairs suggests that successful surgical attenuation of EHPSS improves either intestinal absorption of lipids, fat metabolism in the liver, or a combination of both.}},
  author       = {{Devriendt, Nausikaa and Rodrigues, Tania and Vandenabeele, Sophie and Paepe, Dominique and Stock, Emmelie and De Rooster, Hilde}},
  issn         = {{0959-4493}},
  journal      = {{VETERINARY DERMATOLOGY}},
  keywords     = {{General Veterinary,canine,dermatology,hair,hepatopathy,internal medicine,lipids,PORTACAVAL-SHUNT,SKIN,METABOLISM,LESIONS}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{371--377}},
  title        = {{Total lipid concentration of hairs increases after successful attenuation of extrahepatic portosystemic shunts in dogs}},
  url          = {{http://doi.org/10.1111/vde.13081}},
  volume       = {{33}},
  year         = {{2022}},
}
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