Advanced search
1 file | 2.74 MB Add to list

A hybrid particle-flow CFD modeling approach in truncated hepatic arterial trees for liver radioembolization : a patient-specific case study

Author
Organization
Project
Abstract
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer. At its intermediate, unresectable stage, HCC is typically treated by local injection of embolizing microspheres in the hepatic arteries to selectively damage tumor tissue. Interestingly, computational fluid dynamics (CFD) has been applied increasingly to elucidate the impact of clinically variable parameters, such as injection location, on the downstream particle distribution. This study aims to reduce the computational cost of such CFD approaches by introducing a novel truncation algorithm to simplify hepatic arterial trees, and a hybrid particle-flow modeling approach which only models particles in the first few bifurcations. A patient-specific hepatic arterial geometry was pruned at three different levels, resulting in three trees: Geometry 1 (48 outlets), Geometry 2 (38 outlets), and Geometry 3 (17 outlets). In each geometry, 1 planar injection and 3 catheter injections (each with different tip locations) were performed. For the truncated geometries, it was assumed that, downstream of the truncated outlets, particles distributed themselves proportional to the blood flow. This allowed to compare the particle distribution in all 48 “outlets” for each geometry. For the planar injections, the median difference in outlet-specific particle distribution between Geometry 1 and 3 was 0.21%; while the median difference between outlet-specific flow and particle distribution in Geometry 1 was 0.40%. Comparing catheter injections, the maximum median difference in particle distribution between Geometry 1 and 3 was 0.24%, while the maximum median difference between particle and flow distribution was 0.62%. The results suggest that the hepatic arterial tree might be reliably truncated to estimate the particle distribution in the full-complexity tree. In the resulting hybrid particle-flow model, explicit particle modeling was only deemed necessary in the first few bifurcations of the arterial tree. Interestingly, using flow distribution as a surrogate for particle distribution in the entire tree was considerably less accurate than using the hybrid model, although the difference was much higher for catheter injections than for planar injections. Future work should focus on replicating and experimentally validating these results in more patient-specific geometries.
Keywords
computational fluid dynamics, hepatocellular carcinoma, liver radioembolization, drug delivery & targeting, in silico medicine, pretreatment planning, virtual twins, HEMODYNAMICS, CHEMOEMBOLIZATION, ANATOMY

Downloads

  • Bomberna Frontiers HybridCFDModel.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 2.74 MB

Citation

Please use this url to cite or link to this publication:

MLA
Bomberna, Tim, et al. “A Hybrid Particle-Flow CFD Modeling Approach in Truncated Hepatic Arterial Trees for Liver Radioembolization : A Patient-Specific Case Study.” FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 10, 2022, doi:10.3389/fbioe.2022.914979.
APA
Bomberna, T., Vermijs, S., Lejoly, M., Verslype, C., Bonne, L., Maleux, G., & Debbaut, C. (2022). A hybrid particle-flow CFD modeling approach in truncated hepatic arterial trees for liver radioembolization : a patient-specific case study. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 10. https://doi.org/10.3389/fbioe.2022.914979
Chicago author-date
Bomberna, Tim, Saar Vermijs, Maryse Lejoly, Chris Verslype, Lawrence Bonne, Geert Maleux, and Charlotte Debbaut. 2022. “A Hybrid Particle-Flow CFD Modeling Approach in Truncated Hepatic Arterial Trees for Liver Radioembolization : A Patient-Specific Case Study.” FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10. https://doi.org/10.3389/fbioe.2022.914979.
Chicago author-date (all authors)
Bomberna, Tim, Saar Vermijs, Maryse Lejoly, Chris Verslype, Lawrence Bonne, Geert Maleux, and Charlotte Debbaut. 2022. “A Hybrid Particle-Flow CFD Modeling Approach in Truncated Hepatic Arterial Trees for Liver Radioembolization : A Patient-Specific Case Study.” FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10. doi:10.3389/fbioe.2022.914979.
Vancouver
1.
Bomberna T, Vermijs S, Lejoly M, Verslype C, Bonne L, Maleux G, et al. A hybrid particle-flow CFD modeling approach in truncated hepatic arterial trees for liver radioembolization : a patient-specific case study. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2022;10.
IEEE
[1]
T. Bomberna et al., “A hybrid particle-flow CFD modeling approach in truncated hepatic arterial trees for liver radioembolization : a patient-specific case study,” FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 10, 2022.
@article{8755128,
  abstract     = {{Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer. At its intermediate, unresectable stage, HCC is typically treated by local injection of embolizing microspheres in the hepatic arteries to selectively damage tumor tissue. Interestingly, computational fluid dynamics (CFD) has been applied increasingly to elucidate the impact of clinically variable parameters, such as injection location, on the downstream particle distribution. This study aims to reduce the computational cost of such CFD approaches by introducing a novel truncation algorithm to simplify hepatic arterial trees, and a hybrid particle-flow modeling approach which only models particles in the first few bifurcations. A patient-specific hepatic arterial geometry was pruned at three different levels, resulting in three trees: Geometry 1 (48 outlets), Geometry 2 (38 outlets), and Geometry 3 (17 outlets). In each geometry, 1 planar injection and 3 catheter injections (each with different tip locations) were performed. For the truncated geometries, it was assumed that, downstream of the truncated outlets, particles distributed themselves proportional to the blood flow. This allowed to compare the particle distribution in all 48 “outlets” for each geometry. For the planar injections, the median difference in outlet-specific particle distribution between Geometry 1 and 3 was 0.21%; while the median difference between outlet-specific flow and particle distribution in Geometry 1 was 0.40%. Comparing catheter injections, the maximum median difference in particle distribution between Geometry 1 and 3 was 0.24%, while the maximum median difference between particle and flow distribution was 0.62%. The results suggest that the hepatic arterial tree might be reliably truncated to estimate the particle distribution in the full-complexity tree. In the resulting hybrid particle-flow model, explicit particle modeling was only deemed necessary in the first few bifurcations of the arterial tree. Interestingly, using flow distribution as a surrogate for particle distribution in the entire tree was considerably less accurate than using the hybrid model, although the difference was much higher for catheter injections than for planar injections. Future work should focus on replicating and experimentally validating these results in more patient-specific geometries.}},
  articleno    = {{914979}},
  author       = {{Bomberna, Tim and Vermijs, Saar and Lejoly, Maryse and Verslype, Chris and Bonne, Lawrence and Maleux, Geert and Debbaut, Charlotte}},
  issn         = {{2296-4185}},
  journal      = {{FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY}},
  keywords     = {{computational fluid dynamics,hepatocellular carcinoma,liver radioembolization,drug delivery & targeting,in silico medicine,pretreatment planning,virtual twins,HEMODYNAMICS,CHEMOEMBOLIZATION,ANATOMY}},
  language     = {{eng}},
  pages        = {{18}},
  title        = {{A hybrid particle-flow CFD modeling approach in truncated hepatic arterial trees for liver radioembolization : a patient-specific case study}},
  url          = {{http://doi.org/10.3389/fbioe.2022.914979}},
  volume       = {{10}},
  year         = {{2022}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: